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Q88DW6 (ACSA2_PSEPK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase 2
EC=6.2.1.1
Alternative name(s):
Acetate--CoA ligase 2
Acyl-activating enzyme 2
Gene names
Name:acsA2
Synonyms:acsB
Ordered Locus Names:PP_4702
OrganismPseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]
Taxonomic identifier160488 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length644 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionAMP binding

Inferred from electronic annotation. Source: InterPro

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 644644Acetyl-coenzyme A synthetase 2 HAMAP MF_01123
PRO_0000208377

Sites

Active site5131 By similarity

Amino acid modifications

Modified residue6051N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88DW6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 82D98FD672B86A9A

FASTA64471,251
        10         20         30         40         50         60 
MFDIRKYPQA LAVSQSAALT PEDYRRLYRQ SVEDPDTFWA EQAKRLDWIK PWSSVQQCDL 

        70         80         90        100        110        120 
HTGKARWFDG AQLNVSYNCI DRHLAQRGEQ TALLWEGDDP KDSKAITYRE LHRQVCRLAN 

       130        140        150        160        170        180 
AMKARGVKKG DRVSIYMPMI PEAAFAMLAC TRIGAIHSVV FGGFSPDALR DRILDADCRT 

       190        200        210        220        230        240 
VITADEGVRG GKRIPLKQNV DKALASCPAV SSVLVVRRTG GDVAWTEGRD LWYHEATKDA 

       250        260        270        280        290        300 
GDDCPPEPME AEDPLFILYT SGSTGKPKGV LHTTGGYLLQ ATMTFKVVFD YRDGEVFWCT 

       310        320        330        340        350        360 
ADVGWVTGHS YIVYGPLANG AISLMFEGVP NYPDTSRFWQ VVDKHQVNIF YTAPTALRAL 

       370        380        390        400        410        420 
MREGSAPLQS TSRKSLRLLG SVGEPINPEA WEWYFEEVGQ KRCPIVDTWW QTETGGIMLT 

       430        440        450        460        470        480 
PLPGTQSLKP GCATQPMFGV QPVLLDEKGK LIEGPGAGVL AIKASWPGQI RSVYGDHQRM 

       490        500        510        520        530        540 
VDTYFKPLPG YYFTGDGARR DADGDYWITG RIDDVINVSG HRIGTAEVES ALVLHDSVAE 

       550        560        570        580        590        600 
AAVVGYPHDL KGQGVYAFVT TMNGVTPDDT LKAELLALVS KEIGSFAKPE LIQWAPALPK 

       610        620        630        640 
TRSGKIMRRI LRKIACNELE NLGDTSTLAD PSVVQGLIDK RLNQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015451 Genomic DNA. Translation: AAN70275.1.
RefSeqNP_746811.1. NC_002947.3.

3D structure databases

ProteinModelPortalQ88DW6.
SMRQ88DW6. Positions 13-641.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ88DW6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1041843.
GenomeReviewsGene locus PP_4702 in contig AE015451_GR.
KEGGppu:PP_4702.
NMPDRfig|160488.1.peg.4641.
PATRIC19948160. VBIPsePut30601_5012.
TIGRPP_4702.

Phylogenomic databases

eggNOGCOG0365.
HOGENOMHBG547964.
OMAHQRMVDT.
PhylomeDBQ88DW6.
ProtClustDBPRK00174.

Enzyme and pathway databases

BioCycPPUT160488:PP_4702-MONOMER.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACSA2_PSEPK
AccessionPrimary (citable) accession number: Q88DW6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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