Reviewed, UniProtKB/Swiss-Prot Q88DF7 (PNCB_PSEPK)

Names and origin

Protein names

Recommended name:
    Nicotinate phosphoribosyltransferase
      Short name=NAPRTase
    EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	PP_4868

Organism

Pseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]

Taxonomic identifier

160488 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP MF_00570
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Nicotinate phosphoribosyltransferase HAMAP MF_00570		PRO_0000205839

Sequences

	Sequence		Length	Mass (Da)
	Q88DF7-1 [UniParc]. Last modified July 5, 2005. Version 2. Checksum: AD30738BE61C3089	FASTA	401	46,218
	10 20 30 40 50 60 MSESAFAERI VHNLLDTDFY KLTMMQGVLH NYPDADVEWE FRCRNGEDLR PYLGEIRNQL 70 80 90 100 110 120 ERLADLTLDD GQLAFLERIS FLKPDFLRFL RLFRFNLRYV HVGIENDQLF LRLKGPWLHV 130 140 150 160 170 180 ILFEVPLLAI ISEVRNRNLH PHMRLAEARD QLYRKFDWLR AHASDDELAE LQVADFGTRR 190 200 210 220 230 240 RFSSRVQEEV ARVLRDDFPG RFVGTSNVDL AWKLDIKPLG TMAHEWIMAH QQLGPRLIDS 250 260 270 280 290 300 QIAALDCWVR EYRGLLGIAL TDCITMDAFL GDFDLYFAKL FDGLRHDSGE PVAWAEKAIA 310 320 330 340 350 360 HYQKLGIDPM TKTLVFSDGL NLTRSLEIFR ALRGRINVSF GIGTNLTCDI PGVAPMNIVL 370 380 390 400 KMTDCNGAPV AKISDEAAKT QCRDENFVAY MRHVFKVPSK E

References

[1]

"Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440." Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H., Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M., Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F., Madupu R., Nelson W.C., White O. , Peterson J.D., Khouri H.M., Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M. Environ. Microbiol. 4:799-808(2002) [PubMed: 12534463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015451 Genomic DNA. Translation: AAN70437.1. Different initiation.
RefSeq	NP_746973.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q88DF7.
Genome annotation databases
GeneID	1043392.
GenomeReviews	Gene locus PP_4868 in contig AE015451_GR.
KEGG	ppu:PP_4868.
NMPDR	fig|160488.1.peg.4803.
TIGR	PP_4868.
Phylogenomic databases
HOGENOM	Q88DF7.
OMA	ALTDTFG.
Enzyme and pathway databases
BioCyc	PPUT160488:PP_4868-MON.
Family and domain databases
HAMAP	MF_00570. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. [Graphical view]
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_PSEPK

Accession

Primary (citable) accession number: Q88DF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 5, 2005
Last modified:	November 3, 2009
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)