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Q88DF7

- PNCB_PSEPK

UniProt

Q88DF7 - PNCB_PSEPK

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Protein

Nicotinate phosphoribosyltransferase

Gene
pncB, PP_4868
Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-4962-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:PP_4868
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Nicotinate phosphoribosyltransferaseUniRule annotationPRO_0000205839Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_4868.

Structurei

3D structure databases

ProteinModelPortaliQ88DF7.
SMRiQ88DF7. Positions 1-397.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88DF7-1 [UniParc]FASTAAdd to Basket

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MSESAFAERI VHNLLDTDFY KLTMMQGVLH NYPDADVEWE FRCRNGEDLR    50
PYLGEIRNQL ERLADLTLDD GQLAFLERIS FLKPDFLRFL RLFRFNLRYV 100
HVGIENDQLF LRLKGPWLHV ILFEVPLLAI ISEVRNRNLH PHMRLAEARD 150
QLYRKFDWLR AHASDDELAE LQVADFGTRR RFSSRVQEEV ARVLRDDFPG 200
RFVGTSNVDL AWKLDIKPLG TMAHEWIMAH QQLGPRLIDS QIAALDCWVR 250
EYRGLLGIAL TDCITMDAFL GDFDLYFAKL FDGLRHDSGE PVAWAEKAIA 300
HYQKLGIDPM TKTLVFSDGL NLTRSLEIFR ALRGRINVSF GIGTNLTCDI 350
PGVAPMNIVL KMTDCNGAPV AKISDEAAKT QCRDENFVAY MRHVFKVPSK 400
E 401
Length:401
Mass (Da):46,218
Last modified:July 5, 2005 - v2
Checksum:iAD30738BE61C3089
GO

Sequence cautioni

The sequence AAN70437.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN70437.1. Different initiation.
RefSeqiNP_746973.1. NC_002947.3.
WP_010955468.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN70437; AAN70437; PP_4868.
GeneIDi1043392.
KEGGippu:PP_4868.
PATRICi19948538. VBIPsePut30601_5200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN70437.1 . Different initiation.
RefSeqi NP_746973.1. NC_002947.3.
WP_010955468.1. NC_002947.3.

3D structure databases

ProteinModelPortali Q88DF7.
SMRi Q88DF7. Positions 1-397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160488.PP_4868.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN70437 ; AAN70437 ; PP_4868 .
GeneIDi 1043392.
KEGGi ppu:PP_4868.
PATRICi 19948538. VBIPsePut30601_5200.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci PPUT160488:GIXO-4962-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiPNCB_PSEPK
AccessioniPrimary (citable) accession number: Q88DF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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