Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi389 – 396ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:PP_4935
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalUniRule annotationAdd BLAST21
Transmembranei84 – 104HelicalUniRule annotationAdd BLAST21
Transmembranei158 – 178HelicalUniRule annotationAdd BLAST21
Transmembranei180 – 200HelicalUniRule annotationAdd BLAST21
Transmembranei268 – 288HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925941 – 602Lipid A export ATP-binding/permease protein MsbAAdd BLAST602

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi160488.PP_4935.

Structurei

3D structure databases

ProteinModelPortaliQ88D92.
SMRiQ88D92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 323ABC transmembrane type-1UniRule annotationAdd BLAST293
Domaini355 – 591ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88D92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETPRPAEH TSSLKIYFRL LSYVKPYVGI FLLSIVGFVI FASTQPMLAG
60 70 80 90 100
ILKYFVDGLS NPEAVLFPNV PYLRDLQLLQ AVPLLIILIA AWQGLGSFLG
110 120 130 140 150
NYFLAKVSLS LVHDLRVALF NKLLVLPNRY FDNHNSGHLI SRITFNVTMV
160 170 180 190 200
TGAATDAIKV VIREGLTVVF LFAYLLWMNW HLTLVMVAIL PVIAVMVSIA
210 220 230 240 250
SKKFRKQSKK IQVAMGDVTH VASETIQGYR VVRSFGGEAY EQQRFGQASQ
260 270 280 290 300
SNTDKQLRMT KTGSLYTPML QLVIYSAMAA LMFLVLFLRG DSTAGDLVAY
310 320 330 340 350
ITAAGLLPKP IRQLSEVSST IQKGLAGAES IFEQLDEAPE VDTGTVEKER
360 370 380 390 400
VEGRLEVRNL SFTYPGTERE VLSDISFVAE PGQMIALVGR SGSGKSTLAA
410 420 430 440 450
LIPRFYHHDK GQILLDGVEI EHYRLRNLRR HVSQVTQHVT LFNDTVANNI
460 470 480 490 500
AYGDLAGAPR ADIEAAAADA YAKEFVDRLP KGFDTEVGEN GVLLSGGQRQ
510 520 530 540 550
RLAIARALLK NAPLLILDEA TSALDTESER HIQAALDHVM QGRTTLVIAH
560 570 580 590 600
RLSTIEKADQ ILVMDQGRLV ERGTHTELLA ANGHYARLHA MGLDEPAKAD

IT
Length:602
Mass (Da):66,280
Last modified:June 1, 2003 - v1
Checksum:i5C4A0603A13E5A8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN70502.1.
RefSeqiNP_747038.1. NC_002947.4.
WP_010955513.1. NC_002947.4.

Genome annotation databases

EnsemblBacteriaiAAN70502; AAN70502; PP_4935.
GeneIDi1043843.
KEGGippu:PP_4935.
PATRICifig|160488.4.peg.5269.

Similar proteinsi

Entry informationi

Entry nameiMSBA_PSEPK
AccessioniPrimary (citable) accession number: Q88D92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families