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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K+UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. NAD/NADP-dependent betaine aldehyde dehydrogenase (betB)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Potassium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi93Potassium 1UniRule annotation1
Active sitei162Charge relay systemUniRule annotation1
Metal bindingi180Potassium 1; via carbonyl oxygenUniRule annotation1
Binding sitei209NAD/NADP; via amide nitrogenUniRule annotation1
Metal bindingi246Potassium 2; via carbonyl oxygenUniRule annotation1
Sitei248Seems to be a necessary countercharge to the potassium cationsUniRule annotation1
Active sitei252Proton acceptorUniRule annotation1
Binding sitei286NAD/NADPUniRule annotation1
Binding sitei387NAD/NADPUniRule annotation1
Metal bindingi457Potassium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi460Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei464Charge relay systemUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi150 – 153NAD/NADPUniRule annotation4
Nucleotide bindingi176 – 179NAD/NADPUniRule annotation4
Nucleotide bindingi229 – 234NAD/NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciPPUT160488:G1G01-5407-MONOMER
UniPathwayiUPA00529; UER00386

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotation
Ordered Locus Names:PP_5063
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000565471 – 490NAD/NADP-dependent betaine aldehyde dehydrogenaseAdd BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei286Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

Oxidation

Proteomic databases

PRIDEiQ88CW7

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi160488.PP_5063

Structurei

3D structure databases

ProteinModelPortaliQ88CW7
SMRiQ88CW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG1012 LUCA
HOGENOMiHOG000271505
KOiK00130
OMAiSFGYTRR

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00804 BADH, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR011264 BADH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01804 BADH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Q88CW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFGTQKLY IDGAYVDAGS DATFEAINPA TGEVLAHVQR ATEADVEKAV
60 70 80 90 100
ESAERGQKVW AAMTAMQRSR ILRRAVDILR ERNDELAMLE TLDTGKSYSE
110 120 130 140 150
TRYVDIVTGA DVLEYYAGLV PAIEGEQIPL RESSFVYTRR EPLGVTVGIG
160 170 180 190 200
AWNYPIQIAL WKSAPALAAG NAMIFKPSEV TSLTTLKLAE IYTEAGLPNG
210 220 230 240 250
VFNVLTGSGR EVGTWLTEHP RIEKVSFTGG TTTGKKVMAS ASSSSLKEVT
260 270 280 290 300
MELGGKSPLI ICADADLDKA ADIAMMANFY SSGQVCTNGT RVFIPAEMKA
310 320 330 340 350
AFEAKIAERV ARIRVGNPED ENTNFGPLVS FQHMESVLGY IAKGKEEGAR
360 370 380 390 400
VLCGGERLTA GDFAKGAFVA PTVFTDCTDD MTIVKEEIFG PVMSILTYET
410 420 430 440 450
EEEVIRRAND TDYGLAAGVC TNDITRAHRI IHKLEAGICW INAWGESPAE
460 470 480 490
MPVGGYKQSG VGRENGVSSL AQYTRIKSVQ VELGGYNSVF
Length:490
Mass (Da):52,986
Last modified:June 1, 2003 - v1
Checksum:i8B15DD84E88CBFD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA Translation: AAN70628.1
RefSeqiNP_747164.1, NC_002947.4
WP_003249182.1, NC_002947.4

Genome annotation databases

EnsemblBacteriaiAAN70628; AAN70628; PP_5063
GeneIDi1041862
KEGGippu:PP_5063
PATRICifig|160488.4.peg.5405

Similar proteinsi

Entry informationi

Entry nameiBETB_PSEPK
AccessioniPrimary (citable) accession number: Q88CW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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