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Q88CW6

- BETA_PSEPK

UniProt

Q88CW6 - BETA_PSEPK

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Protein
Oxygen-dependent choline dehydrogenase
Gene
betA, PP_5064
Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei475 – 4751 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 3530FAD By similarity
Add
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-5160-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:PP_5064
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Oxygen-dependent choline dehydrogenaseUniRule annotation
PRO_0000205591Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_5064.

Structurei

3D structure databases

ProteinModelPortaliQ88CW6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88CW6-1 [UniParc]FASTAAdd to Basket

« Hide

MSQEFDYIIV GAGSAGNTLA TRLTEDAGVT VLLLEAGGPD YRFDFRTQMP    50
AALAFPLQGR RYNWAYETDP EPYMDGRRME CGRGKGLGGS SLINGMCYIR 100
GNAMDFDGWA ELPGLEDWTY LDCLPYFRKA ETRDIGPNDY HGGEGPVSVT 150
TPKAGNNPLF HAMVEAGVQA GYPRTEDLNG YQQEGFGPMD RTVTKNGRRS 200
STARGYLDQA KKRPNLTIVT HALTDRVLFD GKRAIGVTYL VGDSEERVEA 250
RARKEVIVSS GAIASPQLLQ RSGVGPRALL ESLDIPVVHD LPGVGENLQD 300
HLELYLQYAC TQPVSLYPSL LWWNQPAIGA EWMFNGTGIG ASNQFEAGGF 350
IRTRPEFKWP NIQYHFLPVA INYNGSNGVK EHGFQAHMGS MRSPARGRIQ 400
VKSKDPRQHP SILFNYMSTE QDWQEFRDGI RLTREIMAQP ALDPYRGREI 450
SPGADVQTDE QLDKFIREHA ETAFHPSCSC KMGTDDMAVV DGEGRVHGMK 500
GLRVVDASIM PLIITGNLNA TTIMIAEKIS DKIRGRKPLP RSTAKYYVAG 550
DAPVKGKPMR EVKQG 565
Length:565
Mass (Da):62,545
Last modified:June 1, 2003 - v1
Checksum:i11C36EEBD7D6EF86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN70629.1.
RefSeqiNP_747165.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN70629; AAN70629; PP_5064.
GeneIDi1043008.
KEGGippu:PP_5064.
PATRICi19948954. VBIPsePut30601_5406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN70629.1 .
RefSeqi NP_747165.1. NC_002947.3.

3D structure databases

ProteinModelPortali Q88CW6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 160488.PP_5064.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN70629 ; AAN70629 ; PP_5064 .
GeneIDi 1043008.
KEGGi ppu:PP_5064.
PATRICi 19948954. VBIPsePut30601_5406.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci PPUT160488:GIXO-5160-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiBETA_PSEPK
AccessioniPrimary (citable) accession number: Q88CW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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