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Q88CI9 (GCSP2_PSEPK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating) 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein 2
Glycine decarboxylase 2
Glycine dehydrogenase (aminomethyl-transferring) 2
Gene names
Name:gcvP2
Synonyms:gcvP-2
Ordered Locus Names:PP_5192
OrganismPseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]
Taxonomic identifier160488 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length957 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 957957Glycine dehydrogenase (decarboxylating) 2 HAMAP-Rule MF_00711
PRO_0000166928

Amino acid modifications

Modified residue7071N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88CI9 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 85277F8806A51C46

FASTA957104,038
        10         20         30         40         50         60 
MSQSPSLHQL QELNPFLRRH LGPDATEQQA MLNALGIASR NELIEQTVPP DIRLNRPLDL 

        70         80         90        100        110        120 
PAALDEQAAL AKLAGYAEQN QVWTSLIGMG YHGTITPTVI LRNVLENPGW YTAYTPYQPE 

       130        140        150        160        170        180 
IAQGRLEALL NFQQMVIDLT GLPLANASLL DEATAAAEAM ALAKRVARNK SNAFFADEHC 

       190        200        210        220        230        240 
HPQTLSVLKT RAEGFGFELI VDSVDNLAKH SVFGALLQYP DTHGEVRDLR PLIDQLHSQQ 

       250        260        270        280        290        300 
ALACVAADLL SLVVLAPPGE LGADVVLGST QRFGVPMGYG GPHAAYFACR DDYKRAMPGR 

       310        320        330        340        350        360 
IIGVSRDARG NTALRMALQT REQHIRREKA NSNICTAQVL LANIAGFYAV YHGPEGLQRI 

       370        380        390        400        410        420 
AQRVHRLTFI LAAGLEAKGI KRLNQHFFDT LTLNVGGAQA AIIESAEAAH INLRILGRGH 

       430        440        450        460        470        480 
LGVSLDETCT EQTVLRLLDI FLGVDHGLEI TALDQLALPE GIPASLVRRT PFLAHPVFNL 

       490        500        510        520        530        540 
HHSETEMLRY LKQLENKDLA LNQSMIPLGS CTMKLNATSE MIPITWPGFA QLHPFAPAAQ 

       550        560        570        580        590        600 
AAGYKAMIDE LESWLCAITG FDAICMQPNS GAQGEYAGLM AITRYHCSRH QPMRTLCLIP 

       610        620        630        640        650        660 
SSAHGTNPAS AQMAGMEVVI VDCDNDGNVD LADLKAKAHA AGERLSCLMI TYPSTHGVYE 

       670        680        690        700        710        720 
EGIREICDVV HQYGGQVYMD GANLNAQVGL ARPADIGADV SHMNLHKTFC IPHGGGGPGM 

       730        740        750        760        770        780 
GPIGIRAHLK PFVASHPVVP VPGLDPNNSA VSAAPWGSAS ILPISWMYIA MMGPQLADAS 

       790        800        810        820        830        840 
EVAILSANYL ASQLGAAFPV LYRGRNQRVA HECILDLRPL KALTGISEED VAKRLMDYGF 

       850        860        870        880        890        900 
HAPTMSFPVP GTLMVEPTES ESKAELDRFV EAMLAIRAEI DEVQQGNWPA ENNPLKHAPH 

       910        920        930        940        950 
TLADVLGVWD RPYSLEQAVA PSAHVRQHKY WPAVNRVDNV YGDRNLFCAC VPVEAYR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015451 Genomic DNA. Translation: AAN70757.1.
RefSeqNP_747293.1. NC_002947.3.

3D structure databases

ProteinModelPortalQ88CI9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING160488.PP_5192.

Proteomic databases

PRIDEQ88CI9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN70757; AAN70757; PP_5192.
GeneID1042488.
KEGGppu:PP_5192.
PATRIC19949222. VBIPsePut30601_5540.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMALNQHFFD.
OrthoDBEOG6HMXDX.
ProtClustDBPRK12566.

Enzyme and pathway databases

BioCycPPUT160488:GIXO-5288-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR018247. EF_Hand_1_Ca_BS.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP2_PSEPK
AccessionPrimary (citable) accession number: Q88CI9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families