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Protein

Glycine dehydrogenase (decarboxylating) 2

Gene

gcvP2

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity).By similarity

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-5288-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein 2
Glycine decarboxylase 2
Glycine dehydrogenase (aminomethyl-transferring) 2
Gene namesi
Name:gcvP2
Synonyms:gcvP-2
Ordered Locus Names:PP_5192
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating) 2PRO_0000166928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiQ88CI9.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Protein-protein interaction databases

STRINGi160488.PP_5192.

Structurei

3D structure databases

ProteinModelPortaliQ88CI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMMGPQLA.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR018247. EF_Hand_1_Ca_BS.
IPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88CI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSPSLHQL QELNPFLRRH LGPDATEQQA MLNALGIASR NELIEQTVPP
60 70 80 90 100
DIRLNRPLDL PAALDEQAAL AKLAGYAEQN QVWTSLIGMG YHGTITPTVI
110 120 130 140 150
LRNVLENPGW YTAYTPYQPE IAQGRLEALL NFQQMVIDLT GLPLANASLL
160 170 180 190 200
DEATAAAEAM ALAKRVARNK SNAFFADEHC HPQTLSVLKT RAEGFGFELI
210 220 230 240 250
VDSVDNLAKH SVFGALLQYP DTHGEVRDLR PLIDQLHSQQ ALACVAADLL
260 270 280 290 300
SLVVLAPPGE LGADVVLGST QRFGVPMGYG GPHAAYFACR DDYKRAMPGR
310 320 330 340 350
IIGVSRDARG NTALRMALQT REQHIRREKA NSNICTAQVL LANIAGFYAV
360 370 380 390 400
YHGPEGLQRI AQRVHRLTFI LAAGLEAKGI KRLNQHFFDT LTLNVGGAQA
410 420 430 440 450
AIIESAEAAH INLRILGRGH LGVSLDETCT EQTVLRLLDI FLGVDHGLEI
460 470 480 490 500
TALDQLALPE GIPASLVRRT PFLAHPVFNL HHSETEMLRY LKQLENKDLA
510 520 530 540 550
LNQSMIPLGS CTMKLNATSE MIPITWPGFA QLHPFAPAAQ AAGYKAMIDE
560 570 580 590 600
LESWLCAITG FDAICMQPNS GAQGEYAGLM AITRYHCSRH QPMRTLCLIP
610 620 630 640 650
SSAHGTNPAS AQMAGMEVVI VDCDNDGNVD LADLKAKAHA AGERLSCLMI
660 670 680 690 700
TYPSTHGVYE EGIREICDVV HQYGGQVYMD GANLNAQVGL ARPADIGADV
710 720 730 740 750
SHMNLHKTFC IPHGGGGPGM GPIGIRAHLK PFVASHPVVP VPGLDPNNSA
760 770 780 790 800
VSAAPWGSAS ILPISWMYIA MMGPQLADAS EVAILSANYL ASQLGAAFPV
810 820 830 840 850
LYRGRNQRVA HECILDLRPL KALTGISEED VAKRLMDYGF HAPTMSFPVP
860 870 880 890 900
GTLMVEPTES ESKAELDRFV EAMLAIRAEI DEVQQGNWPA ENNPLKHAPH
910 920 930 940 950
TLADVLGVWD RPYSLEQAVA PSAHVRQHKY WPAVNRVDNV YGDRNLFCAC

VPVEAYR
Length:957
Mass (Da):104,038
Last modified:June 1, 2003 - v1
Checksum:i85277F8806A51C46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN70757.1.
RefSeqiNP_747293.1. NC_002947.3.
WP_010955717.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN70757; AAN70757; PP_5192.
GeneIDi1042488.
KEGGippu:PP_5192.
PATRICi19949222. VBIPsePut30601_5540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN70757.1.
RefSeqiNP_747293.1. NC_002947.3.
WP_010955717.1. NC_002947.3.

3D structure databases

ProteinModelPortaliQ88CI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160488.PP_5192.

Proteomic databases

PRIDEiQ88CI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN70757; AAN70757; PP_5192.
GeneIDi1042488.
KEGGippu:PP_5192.
PATRICi19949222. VBIPsePut30601_5540.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMMGPQLA.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-5288-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR018247. EF_Hand_1_Ca_BS.
IPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiGCSP2_PSEPK
AccessioniPrimary (citable) accession number: Q88CI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.