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Q88CI9

- GCSP2_PSEPK

UniProt

Q88CI9 - GCSP2_PSEPK

Protein

Glycine dehydrogenase (decarboxylating) 2

Gene

gcvP2

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.By similarity

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPPUT160488:GIXO-5288-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating) 2 (EC:1.4.4.2)
    Alternative name(s):
    Glycine cleavage system P-protein 2
    Glycine decarboxylase 2
    Glycine dehydrogenase (aminomethyl-transferring) 2
    Gene namesi
    Name:gcvP2
    Synonyms:gcvP-2
    Ordered Locus Names:PP_5192
    OrganismiPseudomonas putida (strain KT2440)
    Taxonomic identifieri160488 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000556: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 957957Glycine dehydrogenase (decarboxylating) 2PRO_0000166928Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiQ88CI9.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

    Protein-protein interaction databases

    STRINGi160488.PP_5192.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88CI9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.Curated

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiIRVQVII.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR018247. EF_Hand_1_Ca_BS.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q88CI9-1 [UniParc]FASTAAdd to Basket

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    MSQSPSLHQL QELNPFLRRH LGPDATEQQA MLNALGIASR NELIEQTVPP    50
    DIRLNRPLDL PAALDEQAAL AKLAGYAEQN QVWTSLIGMG YHGTITPTVI 100
    LRNVLENPGW YTAYTPYQPE IAQGRLEALL NFQQMVIDLT GLPLANASLL 150
    DEATAAAEAM ALAKRVARNK SNAFFADEHC HPQTLSVLKT RAEGFGFELI 200
    VDSVDNLAKH SVFGALLQYP DTHGEVRDLR PLIDQLHSQQ ALACVAADLL 250
    SLVVLAPPGE LGADVVLGST QRFGVPMGYG GPHAAYFACR DDYKRAMPGR 300
    IIGVSRDARG NTALRMALQT REQHIRREKA NSNICTAQVL LANIAGFYAV 350
    YHGPEGLQRI AQRVHRLTFI LAAGLEAKGI KRLNQHFFDT LTLNVGGAQA 400
    AIIESAEAAH INLRILGRGH LGVSLDETCT EQTVLRLLDI FLGVDHGLEI 450
    TALDQLALPE GIPASLVRRT PFLAHPVFNL HHSETEMLRY LKQLENKDLA 500
    LNQSMIPLGS CTMKLNATSE MIPITWPGFA QLHPFAPAAQ AAGYKAMIDE 550
    LESWLCAITG FDAICMQPNS GAQGEYAGLM AITRYHCSRH QPMRTLCLIP 600
    SSAHGTNPAS AQMAGMEVVI VDCDNDGNVD LADLKAKAHA AGERLSCLMI 650
    TYPSTHGVYE EGIREICDVV HQYGGQVYMD GANLNAQVGL ARPADIGADV 700
    SHMNLHKTFC IPHGGGGPGM GPIGIRAHLK PFVASHPVVP VPGLDPNNSA 750
    VSAAPWGSAS ILPISWMYIA MMGPQLADAS EVAILSANYL ASQLGAAFPV 800
    LYRGRNQRVA HECILDLRPL KALTGISEED VAKRLMDYGF HAPTMSFPVP 850
    GTLMVEPTES ESKAELDRFV EAMLAIRAEI DEVQQGNWPA ENNPLKHAPH 900
    TLADVLGVWD RPYSLEQAVA PSAHVRQHKY WPAVNRVDNV YGDRNLFCAC 950
    VPVEAYR 957
    Length:957
    Mass (Da):104,038
    Last modified:June 1, 2003 - v1
    Checksum:i85277F8806A51C46
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN70757.1.
    RefSeqiNP_747293.1. NC_002947.3.

    Genome annotation databases

    EnsemblBacteriaiAAN70757; AAN70757; PP_5192.
    GeneIDi1042488.
    KEGGippu:PP_5192.
    PATRICi19949222. VBIPsePut30601_5540.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN70757.1 .
    RefSeqi NP_747293.1. NC_002947.3.

    3D structure databases

    ProteinModelPortali Q88CI9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160488.PP_5192.

    Proteomic databases

    PRIDEi Q88CI9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN70757 ; AAN70757 ; PP_5192 .
    GeneIDi 1042488.
    KEGGi ppu:PP_5192.
    PATRICi 19949222. VBIPsePut30601_5540.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi IRVQVII.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PPUT160488:GIXO-5288-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR018247. EF_Hand_1_Ca_BS.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT2440.

    Entry informationi

    Entry nameiGCSP2_PSEPK
    AccessioniPrimary (citable) accession number: Q88CI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3