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Protein

Alanine racemase

Gene

dadX

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (dadX), Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Active sitei253Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei301Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:dadXImported
Ordered Locus Names:PP_5269Imported
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)Imported
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_5269.

Structurei

3D structure databases

ProteinModelPortaliQ88CB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 355Ala_racemase_CInterPro annotationAdd BLAST124

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031446.
KOiK01775.
OMAiWEILCGF.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88CB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPARALIDL QALRHNYRLA RELTGAKALA VIKADAYGHG AVRCALALEA
60 70 80 90 100
EADGFAVACI EEALELRAAG IKAPVLLLEG FFEASELALI AEHDLWCVVH
110 120 130 140 150
SLWQLEAIEK TPLHKPLNVW LKLDSGMHRV GLHPKDYHDA YQRLLASGKV
160 170 180 190 200
SRIVLMTHFA RADELDADAT SQQIAVFEAA RQGLAAECSL RNSPGVLGWP
210 220 230 240 250
QAPSDWVRPG LMLYGATPFE VAQAEAARLQ PVMTLQSRVI SVRELPAGEP
260 270 280 290 300
VGYGAKFVSP RPTRVGVVAM GYADGYPRQA PNGTPVLVAG KRTQLIGRVS
310 320 330 340 350
MDMLSIDLTD VPQATVGSPV EFWGKQVLAS EVAAHAGTIP YQIFCNLKRV

PRDYIGE
Length:357
Mass (Da):38,766
Last modified:June 1, 2003 - v1
Checksum:iED4D7DE7CAE5684B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN70834.1.
RefSeqiNP_747370.1. NC_002947.4.
WP_010955779.1. NC_002947.4.

Genome annotation databases

EnsemblBacteriaiAAN70834; AAN70834; PP_5269.
GeneIDi1041674.
KEGGippu:PP_5269.
PATRICifig|160488.4.peg.5622.

Similar proteinsi

Entry informationi

Entry nameiQ88CB2_PSEPK
AccessioniPrimary (citable) accession number: Q88CB2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 27, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported