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Q88C93

- ALGC_PSEPK

UniProt

Q88C93 - ALGC_PSEPK

Protein

Phosphomannomutase/phosphoglucomutase

Gene

algC

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production By similarity.By similarity

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
    Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei108 – 1081Phosphoserine intermediateBy similarity
    Metal bindingi108 – 1081Magnesium; via phosphate groupBy similarity
    Metal bindingi242 – 2421MagnesiumBy similarity
    Metal bindingi244 – 2441MagnesiumBy similarity
    Metal bindingi246 – 2461MagnesiumBy similarity
    Binding sitei325 – 3251SubstrateBy similarity
    Binding sitei327 – 3271SubstrateBy similarity
    Binding sitei329 – 3291SubstrateBy similarity
    Sitei421 – 4211Interacts with the biphosphorylated intermediateBy similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. phosphoglucomutase activity Source: UniProtKB-EC
    3. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. alginic acid biosynthetic process Source: UniProtKB-KW
    2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    3. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Alginate biosynthesis, Lipopolysaccharide biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciPPUT160488:GIXO-5384-MONOMER.
    UniPathwayiUPA00030.
    UPA00126; UER00424.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase/phosphoglucomutase (EC:5.4.2.2, EC:5.4.2.8)
    Short name:
    PMM / PGM
    Gene namesi
    Name:algC
    Ordered Locus Names:PP_5288
    OrganismiPseudomonas putida (strain KT2440)
    Taxonomic identifieri160488 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000556: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 463463Phosphomannomutase/phosphoglucomutasePRO_0000147815Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi160488.PP_5288.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88C93.
    SMRiQ88C93. Positions 9-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphohexose mutase family.Curated

    Phylogenomic databases

    eggNOGiCOG1109.
    HOGENOMiHOG000268679.
    KOiK15778.
    OMAiEPMVKPT.
    OrthoDBiEOG6W9X55.

    Family and domain databases

    Gene3Di3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    IPR005841. Alpha-D-phosphohexomutase_SF.
    [Graphical view]
    PfamiPF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view]
    PRINTSiPR00509. PGMPMM.
    SUPFAMiSSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEiPS00710. PGM_PMM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q88C93-1 [UniParc]FASTAAdd to Basket

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    MAHLVPAALP DSIFRAYDIR GVVGKTLHAE TAYWIGRAIG AQSLAQGEPQ    50
    VSVGRDGRLS GPMLVEQLIK GLVDAGCNVS DVGLVPTPAL YYAANVLAGK 100
    SGVMLTGSHN PSDYNGFKIV IAGDTLANEQ IQALLTRLKT NDLTLAQGRV 150
    EKVEILDRYF KQIVGDVKLA KKLKVVVDCG NGAAGVVAPQ LIEALGCEVI 200
    PLFCEVDGNF PNHHPDPGKP ENLEDLIAKV KETGADIGLA FDGDGDRVGV 250
    VTNTGSIVYP DRLLMLFAQD VLSRNPGAEI IFDVKCTRRL TPLIEQHGGR 300
    ALMWKTGHSL IKKKMKQTGS LLAGEMSGHI FIKERWYGFD DGIYSAARLL 350
    EILSKTEQSA ENLFAAFPND ISTPEINIDV TDEGKFSIID ALQRDADWGE 400
    ANLTTIDGVR VDYANGWGLV RASNTTPVLV LRFEADSDAE LQRIKDVFRT 450
    QLLRVEPELQ LPF 463
    Length:463
    Mass (Da):50,272
    Last modified:June 1, 2003 - v1
    Checksum:iEAABA30BE7E926F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN70853.1.
    RefSeqiNP_747389.1. NC_002947.3.
    WP_010955793.1. NC_002947.3.

    Genome annotation databases

    EnsemblBacteriaiAAN70853; AAN70853; PP_5288.
    GeneIDi1042276.
    KEGGippu:PP_5288.
    PATRICi19949422. VBIPsePut30601_5640.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN70853.1 .
    RefSeqi NP_747389.1. NC_002947.3.
    WP_010955793.1. NC_002947.3.

    3D structure databases

    ProteinModelPortali Q88C93.
    SMRi Q88C93. Positions 9-463.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160488.PP_5288.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN70853 ; AAN70853 ; PP_5288 .
    GeneIDi 1042276.
    KEGGi ppu:PP_5288.
    PATRICi 19949422. VBIPsePut30601_5640.

    Phylogenomic databases

    eggNOGi COG1109.
    HOGENOMi HOG000268679.
    KOi K15778.
    OMAi EPMVKPT.
    OrthoDBi EOG6W9X55.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00126 ; UER00424 .
    BioCyci PPUT160488:GIXO-5384-MONOMER.

    Family and domain databases

    Gene3Di 3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    IPR005841. Alpha-D-phosphohexomutase_SF.
    [Graphical view ]
    Pfami PF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view ]
    PRINTSi PR00509. PGMPMM.
    SUPFAMi SSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEi PS00710. PGM_PMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT2440.

    Entry informationi

    Entry nameiALGC_PSEPK
    AccessioniPrimary (citable) accession number: Q88C93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3