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Protein

Phosphomannomutase/phosphoglucomutase

Gene

algC

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production (By similarity).By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Alginate biosynthesis protein AlgA (algA)
  2. Phosphomannomutase/phosphoglucomutase (algC)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Phosphoserine intermediateBy similarity1
Metal bindingi108Magnesium; via phosphate groupBy similarity1
Metal bindingi242MagnesiumBy similarity1
Metal bindingi244MagnesiumBy similarity1
Metal bindingi246MagnesiumBy similarity1
Binding sitei325SubstrateBy similarity1
Binding sitei327SubstrateBy similarity1
Binding sitei329SubstrateBy similarity1
Sitei421Interacts with the biphosphorylated intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Multifunctional enzyme
Biological processAlginate biosynthesis, Lipopolysaccharide biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciPPUT160488:G1G01-5645-MONOMER
UniPathwayiUPA00030
UPA00126; UER00424

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase/phosphoglucomutase (EC:5.4.2.2, EC:5.4.2.8)
Short name:
PMM / PGM
Gene namesi
Name:algC
Ordered Locus Names:PP_5288
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001478151 – 463Phosphomannomutase/phosphoglucomutaseAdd BLAST463

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ88C93

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi160488.PP_5288

Structurei

3D structure databases

ProteinModelPortaliQ88C93
SMRiQ88C93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiENOG4107QKV Bacteria
COG1109 LUCA
HOGENOMiHOG000268679
KOiK15778
OMAiHSGEINF

Family and domain databases

InterProiView protein in InterPro
IPR005844 A-D-PHexomutase_a/b/a-I
IPR016055 A-D-PHexomutase_a/b/a-I/II/III
IPR005845 A-D-PHexomutase_a/b/a-II
IPR005846 A-D-PHexomutase_a/b/a-III
IPR005843 A-D-PHexomutase_C
IPR036900 A-D-PHexomutase_C_sf
IPR016066 A-D-PHexomutase_CS
IPR005841 Alpha-D-phosphohexomutase_SF
PfamiView protein in Pfam
PF02878 PGM_PMM_I, 1 hit
PF02879 PGM_PMM_II, 1 hit
PF02880 PGM_PMM_III, 1 hit
PF00408 PGM_PMM_IV, 1 hit
PRINTSiPR00509 PGMPMM
SUPFAMiSSF53738 SSF53738, 3 hits
SSF55957 SSF55957, 1 hit
PROSITEiView protein in PROSITE
PS00710 PGM_PMM, 1 hit

Sequencei

Sequence statusi: Complete.

Q88C93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHLVPAALP DSIFRAYDIR GVVGKTLHAE TAYWIGRAIG AQSLAQGEPQ
60 70 80 90 100
VSVGRDGRLS GPMLVEQLIK GLVDAGCNVS DVGLVPTPAL YYAANVLAGK
110 120 130 140 150
SGVMLTGSHN PSDYNGFKIV IAGDTLANEQ IQALLTRLKT NDLTLAQGRV
160 170 180 190 200
EKVEILDRYF KQIVGDVKLA KKLKVVVDCG NGAAGVVAPQ LIEALGCEVI
210 220 230 240 250
PLFCEVDGNF PNHHPDPGKP ENLEDLIAKV KETGADIGLA FDGDGDRVGV
260 270 280 290 300
VTNTGSIVYP DRLLMLFAQD VLSRNPGAEI IFDVKCTRRL TPLIEQHGGR
310 320 330 340 350
ALMWKTGHSL IKKKMKQTGS LLAGEMSGHI FIKERWYGFD DGIYSAARLL
360 370 380 390 400
EILSKTEQSA ENLFAAFPND ISTPEINIDV TDEGKFSIID ALQRDADWGE
410 420 430 440 450
ANLTTIDGVR VDYANGWGLV RASNTTPVLV LRFEADSDAE LQRIKDVFRT
460
QLLRVEPELQ LPF
Length:463
Mass (Da):50,272
Last modified:June 1, 2003 - v1
Checksum:iEAABA30BE7E926F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA Translation: AAN70853.1
RefSeqiNP_747389.1, NC_002947.4
WP_010955793.1, NC_002947.4

Genome annotation databases

EnsemblBacteriaiAAN70853; AAN70853; PP_5288
GeneIDi1042276
KEGGippu:PP_5288
PATRICifig|160488.4.peg.5640

Similar proteinsi

Entry informationi

Entry nameiALGC_PSEPK
AccessioniPrimary (citable) accession number: Q88C93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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