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Protein

Phosphomannomutase/phosphoglucomutase

Gene

algC

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production (By similarity).By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081Phosphoserine intermediateBy similarity
Metal bindingi108 – 1081Magnesium; via phosphate groupBy similarity
Metal bindingi242 – 2421MagnesiumBy similarity
Metal bindingi244 – 2441MagnesiumBy similarity
Metal bindingi246 – 2461MagnesiumBy similarity
Binding sitei325 – 3251SubstrateBy similarity
Binding sitei327 – 3271SubstrateBy similarity
Binding sitei329 – 3291SubstrateBy similarity
Sitei421 – 4211Interacts with the biphosphorylated intermediateBy similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. phosphoglucomutase activity Source: UniProtKB-EC
  3. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. alginic acid biosynthetic process Source: UniProtKB-KW
  2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  3. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Alginate biosynthesis, Lipopolysaccharide biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-5384-MONOMER.
UniPathwayiUPA00030.
UPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase/phosphoglucomutase (EC:5.4.2.2, EC:5.4.2.8)
Short name:
PMM / PGM
Gene namesi
Name:algC
Ordered Locus Names:PP_5288
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Phosphomannomutase/phosphoglucomutasePRO_0000147815Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi160488.PP_5288.

Structurei

3D structure databases

ProteinModelPortaliQ88C93.
SMRiQ88C93. Positions 9-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiCOG1109.
HOGENOMiHOG000268679.
KOiK15778.
OMAiMRFESET.
OrthoDBiEOG6W9X55.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88C93-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHLVPAALP DSIFRAYDIR GVVGKTLHAE TAYWIGRAIG AQSLAQGEPQ
60 70 80 90 100
VSVGRDGRLS GPMLVEQLIK GLVDAGCNVS DVGLVPTPAL YYAANVLAGK
110 120 130 140 150
SGVMLTGSHN PSDYNGFKIV IAGDTLANEQ IQALLTRLKT NDLTLAQGRV
160 170 180 190 200
EKVEILDRYF KQIVGDVKLA KKLKVVVDCG NGAAGVVAPQ LIEALGCEVI
210 220 230 240 250
PLFCEVDGNF PNHHPDPGKP ENLEDLIAKV KETGADIGLA FDGDGDRVGV
260 270 280 290 300
VTNTGSIVYP DRLLMLFAQD VLSRNPGAEI IFDVKCTRRL TPLIEQHGGR
310 320 330 340 350
ALMWKTGHSL IKKKMKQTGS LLAGEMSGHI FIKERWYGFD DGIYSAARLL
360 370 380 390 400
EILSKTEQSA ENLFAAFPND ISTPEINIDV TDEGKFSIID ALQRDADWGE
410 420 430 440 450
ANLTTIDGVR VDYANGWGLV RASNTTPVLV LRFEADSDAE LQRIKDVFRT
460
QLLRVEPELQ LPF
Length:463
Mass (Da):50,272
Last modified:June 1, 2003 - v1
Checksum:iEAABA30BE7E926F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN70853.1.
RefSeqiNP_747389.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN70853; AAN70853; PP_5288.
GeneIDi1042276.
KEGGippu:PP_5288.
PATRICi19949422. VBIPsePut30601_5640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN70853.1.
RefSeqiNP_747389.1. NC_002947.3.

3D structure databases

ProteinModelPortaliQ88C93.
SMRiQ88C93. Positions 9-463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160488.PP_5288.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN70853; AAN70853; PP_5288.
GeneIDi1042276.
KEGGippu:PP_5288.
PATRICi19949422. VBIPsePut30601_5640.

Phylogenomic databases

eggNOGiCOG1109.
HOGENOMiHOG000268679.
KOiK15778.
OMAiMRFESET.
OrthoDBiEOG6W9X55.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00126; UER00424.
BioCyciPPUT160488:GIXO-5384-MONOMER.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiALGC_PSEPK
AccessioniPrimary (citable) accession number: Q88C93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: February 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.