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Protein

Guanylate kinase

Gene

gmk

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-5392-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Synonyms:gmk-2
Ordered Locus Names:PP_5296
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Guanylate kinasePRO_0000170588Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_5296.

Structurei

3D structure databases

ProteinModelPortaliQ88C87.
SMRiQ88C87. Positions 4-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 184179Guanylate kinase-likeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation
Contains 1 guanylate kinase-like domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037638.
KOiK00942.
OMAiMEGVKQI.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88C87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSSGTLYI VSAPSGAGKT SLVTALTKDD QQIRVSVSHT TRAMRPGEQH
60 70 80 90 100
GVNYHFVVHE EFKALIAQGD FLEHAEVFGN FYGTSRSALQ QTLDQGYDLI
110 120 130 140 150
LEIDWQGAQQ VRKLMPQALS VFILPPSQEA LRHRLDGRGQ DSEEIIAGRM
160 170 180 190 200
KEAVSEMVHY DEYDYVIIND DFDTALADLK AVFRSNRLLL KKQQQRHAAL

LKQMIG
Length:206
Mass (Da):23,184
Last modified:June 20, 2003 - v1
Checksum:iFDE05B860938B38E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN70861.1.
RefSeqiNP_747397.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN70861; AAN70861; PP_5296.
GeneIDi1042249.
KEGGippu:PP_5296.
PATRICi19949438. VBIPsePut30601_5648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN70861.1.
RefSeqiNP_747397.1. NC_002947.3.

3D structure databases

ProteinModelPortaliQ88C87.
SMRiQ88C87. Positions 4-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160488.PP_5296.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN70861; AAN70861; PP_5296.
GeneIDi1042249.
KEGGippu:PP_5296.
PATRICi19949438. VBIPsePut30601_5648.

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037638.
KOiK00942.
OMAiMEGVKQI.
OrthoDBiEOG6CP410.

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-5392-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiKGUA_PSEPK
AccessioniPrimary (citable) accession number: Q88C87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.