Reviewed, UniProtKB/Swiss-Prot Q88C66 (UBIC_PSEPK)

Names and origin

Protein names

Recommended name:
    Probable chorismate--pyruvate lyase
      Short name=CL
      Short name=CPL
    EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	PP_5317

Organism

Pseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]

Taxonomic identifier

160488 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyruvate biosynthetic process Inferred from electronic annotation. Source: HAMAP ubiquinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Probable chorismate--pyruvate lyase HAMAP MF_01632		PRO_0000240560
Sites
	Binding site	80	1	Substrate By similarity
	Binding site	118	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88C66-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7BA6C28684E053FB	FASTA	185	20,826
	10 20 30 40 50 60 MSYESPQAAA VAWLPYSQLA TDIDQPTLDW LFDEGSLTRR LTRLSIDHFS VTPLFEGWQP 70 80 90 100 110 120 LRDDECQALG IAAGAEGWVR EVYLRGHGQP WVFARSVASR SALERGGLDL ETLGSRSLGE 130 140 150 160 170 180 LLFCDQAFIR HPLEVCTYPQ AWLPSEAAHA ALWGRRSRFE RNGLDLLVAE VFLPALWQAA KEENR

References

[1]

"Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440." Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H., Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M., Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F., Madupu R., Nelson W.C., White O. , Peterson J.D., Khouri H.M., Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M. Environ. Microbiol. 4:799-808(2002) [PubMed: 12534463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015451 Genomic DNA. Translation: AAN70882.1.
RefSeq	NP_747418.1.
3D structure databases
SMR	Q88C66. Positions 6-176.
ModBase	Search...
Protein-protein interaction databases
STRING	Q88C66.
Genome annotation databases
GeneID	1042185.
GenomeReviews	Gene locus PP_5317 in contig AE015451_GR.
KEGG	ppu:PP_5317.
NMPDR	fig|160488.1.peg.5248.
TIGR	PP_5317.
Phylogenomic databases
eggNOG	COG3161.
HOGENOM	HBG644467.
OMA	QPWVFAR.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_PSEPK

Accession

Primary (citable) accession number: Q88C66

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 1, 2003
Last modified:	January 19, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)