Q88C26 (PDXY_PSEPK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyridoxamine kinase
Short name=PM kinase
EC=2.7.1.35

Gene names

Name:	pdxY
Ordered Locus Names:	PP_5357

Organism

Pseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]

Taxonomic identifier

160488 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine By similarity. HAMAP MF_01639
Catalytic activity	ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. HAMAP MF_01639
Sequence similarities	Belongs to the pyridoxine kinase family.

Ontologies

Keywords
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridoxal 5'-phosphate salvage Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Pyridoxamine kinase HAMAP MF_01639		PRO_0000269821
Regions
	Nucleotide binding	184 – 185	2	ATP By similarity
Sites
	Binding site	12	1	Substrate By similarity
	Binding site	47	1	Substrate By similarity
	Binding site	225	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88C26 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 4E408FF6CF62333D	FASTA	290	31,671
	10 20 30 40 50 60 MKRTPHLLAI QSHVVFGHAG NSAAVFPMQR IGVNAWPLNT VQFSNHTQYG QWAGEVLAPA 70 80 90 100 110 120 QIPALVEGIS NIGELGHCDA VLSGYLGSAE QGRAILAGVE RIKAVNPKAL YLCDPVMGHP 130 140 150 160 170 180 EKGCIVPPEV SEFLLDEAAA TADILCPNQL ELDSFCGRRA QSLEDCVNMA RSLLQRGPQV 190 200 210 220 230 240 VLVKHLAYPG RAEEHFEMLL VTAEHSWHLR RPLLAFPRQP VGVGDLTSGL FLARVLLGDS 250 260 270 280 290 WVQAFEFTAA AVHEVLLETQ ACASYELQLV RAQDRIAHPR VRFEAQLLAL

References

[1]

"Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440." Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H., Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M., Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F., Madupu R., Nelson W.C., White O. , Peterson J.D., Khouri H.M., Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M. Environ. Microbiol. 4:799-808(2002) [PubMed: 12534463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KT2440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015451 Genomic DNA. Translation: AAN70922.1.
RefSeq	NP_747458.1. NC_002947.3.
3D structure databases
HSSP	HSSP built from PDB template 1TD2 based on UniProtKB P77150.
ProteinModelPortal	Q88C26.
SMR	Q88C26. Positions 4-288.
ModBase	Search...
Protein-protein interaction databases
STRING	Q88C26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1042125.
GenomeReviews	Gene locus PP_5357 in contig AE015451_GR.
KEGG	ppu:PP_5357.
NMPDR	fig|160488.1.peg.5288.
PATRIC	19949564. VBIPsePut30601_5711.
TIGR	PP_5357.
Phylogenomic databases
eggNOG	COG2240.
HOGENOM	HBG661459.
OMA	CPNQLEL.
PhylomeDB	Q88C26.
ProtClustDB	PRK05756.
Enzyme and pathway databases
BioCyc	PPUT160488:PP_5357-MONOMER.
Family and domain databases
HAMAP	MF_01639. PdxY. [Tree]
InterPro	IPR013749. HMP-P_kinase-1. IPR004625. PyrdxlP_synth_PyrdxlKinase. IPR023685. Pyridoxal_kinase_PdxY. [Graphical view]
KO	K00868.
PANTHER	PTHR10534. PTHR10534. 1 hit.
Pfam	PF08543. Phos_pyr_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00687. Pyridox_kin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDXY_PSEPK

Accession

Primary (citable) accession number: Q88C26

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program