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Q88BX8

- GLMS_PSEPK

UniProt

Q88BX8 - GLMS_PSEPK

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei606 – 6061For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-5505-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:PP_5409
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 611610Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135368Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi160488.PP_5409.

Structurei

3D structure databases

ProteinModelPortaliQ88BX8.
SMRiQ88BX8. Positions 2-611.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini287 – 427141SIS 1UniRule annotationAdd
BLAST
Domaini460 – 601142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q88BX8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGAVAE RNITAILIEG LKRLEYRGYD SAGLAVLTQN GELQRRRRIG
60 70 80 90 100
KVSELEVAVA DDPLAGQLGI AHTRWATHGA PTEGNAHPHF SGNDVAVVHN
110 120 130 140 150
GIIENHEELR EELKGLGYVF TSQTDTEVIV HLIHHTLKSI PDLTDALKAA
160 170 180 190 200
VKRLHGAYGL ALISAKQPDR LVAARSGSPL VIGLGLGENF LASDQLALRQ
210 220 230 240 250
VTDRFMYLEE GDIAEIRRDQ VSIWDQQGNK VQRETVQYHE GAEAADKGAY
260 270 280 290 300
RHFMLKEIHE QPSVVQRTLE GRLGKDNVLV QAFGPQAADL FAKVRNVQIV
310 320 330 340 350
ACGTSYHAGM VARYWLESLA GIPCQVEVAS EFRYRKVVVQ PDTLFVSISQ
360 370 380 390 400
SGETADTLAA LRNAKELGFL GSLAICNVGI SSLVRESDLT LLTLAGPEIG
410 420 430 440 450
VASTKAFTTQ LVSLMLLTLA LGQVRGTLEA GVEAELVEEL RRLPTRLGEA
460 470 480 490 500
LAMDATVEKI AELFADKHHT LFLGRGAQYP VAMEGALKLK EISYIHAEAY
510 520 530 540 550
PAGELKHGPL ALVDNDMPVV TVAPNNELLE KLKSNLQEVR ARGGELVVFA
560 570 580 590 600
DEHAGMTNGE GTHVIKVPHI ADALAPILYT IPLQLLSYYV AVLKGTDVDQ
610
PRNLAKSVTV E
Length:611
Mass (Da):66,313
Last modified:January 23, 2007 - v2
Checksum:i38A0B78A93FA1E93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN70973.1.
RefSeqiNP_747509.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN70973; AAN70973; PP_5409.
GeneIDi1041649.
KEGGippu:PP_5409.
PATRICi19949692. VBIPsePut30601_5776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN70973.1 .
RefSeqi NP_747509.1. NC_002947.3.

3D structure databases

ProteinModelPortali Q88BX8.
SMRi Q88BX8. Positions 2-611.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160488.PP_5409.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN70973 ; AAN70973 ; PP_5409 .
GeneIDi 1041649.
KEGGi ppu:PP_5409.
PATRICi 19949692. VBIPsePut30601_5776.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci PPUT160488:GIXO-5505-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiGLMS_PSEPK
AccessioniPrimary (citable) accession number: Q88BX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3