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Q88BX8

- GLMS_PSEPK

UniProt

Q88BX8 - GLMS_PSEPK

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, PP_5409
Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei606 – 6061For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-5505-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:PP_5409
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 611610Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135368Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi160488.PP_5409.

Structurei

3D structure databases

ProteinModelPortaliQ88BX8.
SMRiQ88BX8. Positions 2-611.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2
Add
BLAST
Domaini287 – 427141SIS 1
Add
BLAST
Domaini460 – 601142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q88BX8-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGAVAE RNITAILIEG LKRLEYRGYD SAGLAVLTQN GELQRRRRIG    50
KVSELEVAVA DDPLAGQLGI AHTRWATHGA PTEGNAHPHF SGNDVAVVHN 100
GIIENHEELR EELKGLGYVF TSQTDTEVIV HLIHHTLKSI PDLTDALKAA 150
VKRLHGAYGL ALISAKQPDR LVAARSGSPL VIGLGLGENF LASDQLALRQ 200
VTDRFMYLEE GDIAEIRRDQ VSIWDQQGNK VQRETVQYHE GAEAADKGAY 250
RHFMLKEIHE QPSVVQRTLE GRLGKDNVLV QAFGPQAADL FAKVRNVQIV 300
ACGTSYHAGM VARYWLESLA GIPCQVEVAS EFRYRKVVVQ PDTLFVSISQ 350
SGETADTLAA LRNAKELGFL GSLAICNVGI SSLVRESDLT LLTLAGPEIG 400
VASTKAFTTQ LVSLMLLTLA LGQVRGTLEA GVEAELVEEL RRLPTRLGEA 450
LAMDATVEKI AELFADKHHT LFLGRGAQYP VAMEGALKLK EISYIHAEAY 500
PAGELKHGPL ALVDNDMPVV TVAPNNELLE KLKSNLQEVR ARGGELVVFA 550
DEHAGMTNGE GTHVIKVPHI ADALAPILYT IPLQLLSYYV AVLKGTDVDQ 600
PRNLAKSVTV E 611
Length:611
Mass (Da):66,313
Last modified:January 23, 2007 - v2
Checksum:i38A0B78A93FA1E93
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN70973.1.
RefSeqiNP_747509.1. NC_002947.3.
WP_010955884.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN70973; AAN70973; PP_5409.
GeneIDi1041649.
KEGGippu:PP_5409.
PATRICi19949692. VBIPsePut30601_5776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN70973.1 .
RefSeqi NP_747509.1. NC_002947.3.
WP_010955884.1. NC_002947.3.

3D structure databases

ProteinModelPortali Q88BX8.
SMRi Q88BX8. Positions 2-611.
ModBasei Search...

Protein-protein interaction databases

STRINGi 160488.PP_5409.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN70973 ; AAN70973 ; PP_5409 .
GeneIDi 1041649.
KEGGi ppu:PP_5409.
PATRICi 19949692. VBIPsePut30601_5776.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci PPUT160488:GIXO-5505-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiGLMS_PSEPK
AccessioniPrimary (citable) accession number: Q88BX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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