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Q88BX8

- GLMS_PSEPK

UniProt

Q88BX8 - GLMS_PSEPK

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei606 – 6061For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciPPUT160488:GIXO-5505-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:PP_5409
    OrganismiPseudomonas putida (strain KT2440)
    Taxonomic identifieri160488 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000556: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 611610Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135368Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi160488.PP_5409.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88BX8.
    SMRiQ88BX8. Positions 2-611.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini287 – 427141SIS 1UniRule annotationAdd
    BLAST
    Domaini460 – 601142SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258898.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q88BX8-1 [UniParc]FASTAAdd to Basket

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    MCGIVGAVAE RNITAILIEG LKRLEYRGYD SAGLAVLTQN GELQRRRRIG    50
    KVSELEVAVA DDPLAGQLGI AHTRWATHGA PTEGNAHPHF SGNDVAVVHN 100
    GIIENHEELR EELKGLGYVF TSQTDTEVIV HLIHHTLKSI PDLTDALKAA 150
    VKRLHGAYGL ALISAKQPDR LVAARSGSPL VIGLGLGENF LASDQLALRQ 200
    VTDRFMYLEE GDIAEIRRDQ VSIWDQQGNK VQRETVQYHE GAEAADKGAY 250
    RHFMLKEIHE QPSVVQRTLE GRLGKDNVLV QAFGPQAADL FAKVRNVQIV 300
    ACGTSYHAGM VARYWLESLA GIPCQVEVAS EFRYRKVVVQ PDTLFVSISQ 350
    SGETADTLAA LRNAKELGFL GSLAICNVGI SSLVRESDLT LLTLAGPEIG 400
    VASTKAFTTQ LVSLMLLTLA LGQVRGTLEA GVEAELVEEL RRLPTRLGEA 450
    LAMDATVEKI AELFADKHHT LFLGRGAQYP VAMEGALKLK EISYIHAEAY 500
    PAGELKHGPL ALVDNDMPVV TVAPNNELLE KLKSNLQEVR ARGGELVVFA 550
    DEHAGMTNGE GTHVIKVPHI ADALAPILYT IPLQLLSYYV AVLKGTDVDQ 600
    PRNLAKSVTV E 611
    Length:611
    Mass (Da):66,313
    Last modified:January 23, 2007 - v2
    Checksum:i38A0B78A93FA1E93
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN70973.1.
    RefSeqiNP_747509.1. NC_002947.3.
    WP_010955884.1. NC_002947.3.

    Genome annotation databases

    EnsemblBacteriaiAAN70973; AAN70973; PP_5409.
    GeneIDi1041649.
    KEGGippu:PP_5409.
    PATRICi19949692. VBIPsePut30601_5776.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN70973.1 .
    RefSeqi NP_747509.1. NC_002947.3.
    WP_010955884.1. NC_002947.3.

    3D structure databases

    ProteinModelPortali Q88BX8.
    SMRi Q88BX8. Positions 2-611.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160488.PP_5409.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN70973 ; AAN70973 ; PP_5409 .
    GeneIDi 1041649.
    KEGGi ppu:PP_5409.
    PATRICi 19949692. VBIPsePut30601_5776.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258898.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci PPUT160488:GIXO-5505-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT2440.

    Entry informationi

    Entry nameiGLMS_PSEPK
    AccessioniPrimary (citable) accession number: Q88BX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3