ID Q88BK2_PSESM Unreviewed; 367 AA. AC Q88BK2; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 27-MAR-2024, entry version 127. DE RecName: Full=Beta sliding clamp {ECO:0000256|ARBA:ARBA00021035, ECO:0000256|PIRNR:PIRNR000804}; GN Name=dnaN {ECO:0000313|EMBL:AAO53559.1}; GN OrderedLocusNames=PSPTO_0002 {ECO:0000313|EMBL:AAO53559.1}; OS Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; OC Pseudomonadaceae; Pseudomonas. OX NCBI_TaxID=223283 {ECO:0000313|EMBL:AAO53559.1, ECO:0000313|Proteomes:UP000002515}; RN [1] {ECO:0000313|EMBL:AAO53559.1, ECO:0000313|Proteomes:UP000002515} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC BAA-871 / DC3000 {ECO:0000313|Proteomes:UP000002515}; RX PubMed=12928499; DOI=10.1073/pnas.1731982100; RA Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T., RA Gwinn M.L., Dodson R.J., Deboy R.T., Durkin A.S., Kolonay J.F., Madupu R., RA Daugherty S., Brinkac L., Beanan M.J., Haft D.H., Nelson W.C., Davidsen T., RA Zafar N., Zhou L., Liu J., Yuan Q., Khouri H., Fedorova N., Tran B., RA Russell D., Berry K., Utterback T., Van Aken S.E., Feldblyum T.V., RA D'Ascenzo M., Deng W.L., Ramos A.R., Alfano J.R., Cartinhour S., RA Chatterjee A.K., Delaney T.P., Lazarowitz S.G., Martin G.B., RA Schneider D.J., Tang X., Bender C.L., White O., Fraser C.M., Collmer A.; RT "The complete genome sequence of the Arabidopsis and tomato pathogen RT Pseudomonas syringae pv. tomato DC3000."; RL Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003). CC -!- FUNCTION: Confers DNA tethering and processivity to DNA polymerases and CC other proteins. Acts as a clamp, forming a ring around DNA (a reaction CC catalyzed by the clamp-loading complex) which diffuses in an ATP- CC independent manner freely and bidirectionally along dsDNA. Initially CC characterized for its ability to contact the catalytic subunit of DNA CC polymerase III (Pol III), a complex, multichain enzyme responsible for CC most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' CC exonuclease proofreading activity. The beta chain is required for CC initiation of replication as well as for processivity of DNA CC replication. {ECO:0000256|PIRNR:PIRNR000804}. CC -!- SUBUNIT: Forms a ring-shaped head-to-tail homodimer around DNA. CC {ECO:0000256|PIRNR:PIRNR000804}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, CC ECO:0000256|PIRNR:PIRNR000804}. CC -!- SIMILARITY: Belongs to the beta sliding clamp family. CC {ECO:0000256|ARBA:ARBA00010752, ECO:0000256|PIRNR:PIRNR000804}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE016853; AAO53559.1; -; Genomic_DNA. DR RefSeq; NP_789864.1; NC_004578.1. DR RefSeq; WP_005768226.1; NC_004578.1. DR AlphaFoldDB; Q88BK2; -. DR STRING; 223283.PSPTO_0002; -. DR GeneID; 1181610; -. DR KEGG; pst:PSPTO_0002; -. DR PATRIC; fig|223283.9.peg.2; -. DR eggNOG; COG0592; Bacteria. DR HOGENOM; CLU_038149_4_2_6; -. DR OrthoDB; 8421503at2; -. DR PhylomeDB; Q88BK2; -. DR Proteomes; UP000002515; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro. DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule. DR CDD; cd00140; beta_clamp; 1. DR Gene3D; 3.70.10.10; -; 1. DR Gene3D; 3.10.150.10; DNA Polymerase III, subunit A, domain 2; 1. DR InterPro; IPR046938; DNA_clamp_sf. DR InterPro; IPR001001; DNA_polIII_beta. DR InterPro; IPR022635; DNA_polIII_beta_C. DR InterPro; IPR022637; DNA_polIII_beta_cen. DR InterPro; IPR022634; DNA_polIII_beta_N. DR NCBIfam; TIGR00663; dnan; 1. DR PANTHER; PTHR30478:SF0; BETA SLIDING CLAMP; 1. DR PANTHER; PTHR30478; DNA POLYMERASE III SUBUNIT BETA; 1. DR Pfam; PF00712; DNA_pol3_beta; 1. DR Pfam; PF02767; DNA_pol3_beta_2; 1. DR Pfam; PF02768; DNA_pol3_beta_3; 1. DR PIRSF; PIRSF000804; DNA_pol_III_b; 1. DR SMART; SM00480; POL3Bc; 1. DR SUPFAM; SSF55979; DNA clamp; 3. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR000804}; KW DNA replication {ECO:0000256|ARBA:ARBA00022705, KW ECO:0000256|PIRNR:PIRNR000804}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932, KW ECO:0000256|PIRNR:PIRNR000804}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, KW ECO:0000256|PIRNR:PIRNR000804}; KW Reference proteome {ECO:0000313|Proteomes:UP000002515}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000804}. FT DOMAIN 1..119 FT /note="DNA polymerase III beta sliding clamp N-terminal" FT /evidence="ECO:0000259|Pfam:PF00712" FT DOMAIN 130..244 FT /note="DNA polymerase III beta sliding clamp central" FT /evidence="ECO:0000259|Pfam:PF02767" FT DOMAIN 247..366 FT /note="DNA polymerase III beta sliding clamp C-terminal" FT /evidence="ECO:0000259|Pfam:PF02768" SQ SEQUENCE 367 AA; 40724 MW; 748498F4D38855C9 CRC64; MHFTIQREAL LKPLQLVAGV VERRQTLPVL SNVLLVVQGQ QLSLTGTDLE VELVGRVQLE EPAEPGEITV PARKLMDICK SLPNDALIDI KLDDSKLIVK AGRSRFTLST LPANDFPTVE EGPGSLTFNL VQSKLRRLIE RTSFAMAQQD VRYYLNGMLL EVSAGILRAV ATDGHRLAMC SMSADIEHAD RHQVIVPRKG ILEMARLLTE QDGMVSIVLG QHHIRATTGE FTFTSKLVDG KFPDYERVLP KGGDKLVLGD RQSLREAFSR TAILSNEKYR GIRLQLANGQ LKIQANNPEQ EEAEEEIGVE YNGEALEIGF NVSYLLDVLS VMTTEQVRLI LSDSNSSALV QESDNDDSAY VVMPMRL //