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Q88BD4

- ALGC_PSESM

UniProt

Q88BD4 - ALGC_PSESM

Protein

Phosphomannomutase/phosphoglucomutase

Gene

algC

Organism
Pseudomonas syringae pv. tomato (strain DC3000)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production By similarity.By similarity

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
    Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei110 – 1101Phosphoserine intermediateBy similarity
    Metal bindingi110 – 1101Magnesium; via phosphate groupBy similarity
    Metal bindingi244 – 2441MagnesiumBy similarity
    Metal bindingi246 – 2461MagnesiumBy similarity
    Metal bindingi248 – 2481MagnesiumBy similarity
    Binding sitei327 – 3271SubstrateBy similarity
    Binding sitei329 – 3291SubstrateBy similarity
    Binding sitei331 – 3311SubstrateBy similarity
    Sitei423 – 4231Interacts with the biphosphorylated intermediateBy similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. phosphoglucomutase activity Source: UniProtKB-EC
    3. phosphomannomutase activity Source: JCVI

    GO - Biological processi

    1. alginic acid biosynthetic process Source: UniProtKB-KW
    2. carbohydrate metabolic process Source: JCVI
    3. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    4. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Alginate biosynthesis, Lipopolysaccharide biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciPSYR223283:GJIX-83-MONOMER.
    UniPathwayiUPA00030.
    UPA00126; UER00424.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase/phosphoglucomutase (EC:5.4.2.2, EC:5.4.2.8)
    Short name:
    PMM / PGM
    Gene namesi
    Name:algC
    Ordered Locus Names:PSPTO_0083
    OrganismiPseudomonas syringae pv. tomato (strain DC3000)
    Taxonomic identifieri223283 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002515: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Phosphomannomutase/phosphoglucomutasePRO_0000147816Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi223283.PSPTO_0083.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88BD4.
    SMRiQ88BD4. Positions 11-465.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphohexose mutase family.Curated

    Phylogenomic databases

    eggNOGiCOG1109.
    HOGENOMiHOG000268679.
    KOiK15778.
    OMAiRPMNIAI.
    OrthoDBiEOG6W9X55.
    PhylomeDBiQ88BD4.

    Family and domain databases

    Gene3Di3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    IPR005841. Alpha-D-phosphohexomutase_SF.
    [Graphical view]
    PfamiPF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view]
    PRINTSiPR00509. PGMPMM.
    SUPFAMiSSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEiPS00710. PGM_PMM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q88BD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSPASVAPI LPDTIFRAYD IRGVVEDTLN AETAYWIGRA IGSESLAQNE    50
    PNVSVGRDGR LSGPELVQQL IQGLHDSGCH VSDVGLVPTP ALYYAANVLA 100
    GKTGVMLTGS HNPKDYNGFK IVIAGDTLAN EQIQALHERI KTNNLTSQKG 150
    SITQVNILDR YFKQIKDDIV MARKLKVVVD CGNGAAGVIA PQLIEALGCE 200
    VISLFAEVDG NFPNHHPDPG KLENLQDLIA KVKETGADLG LAFDGDGDRV 250
    GVVTNAGNVV YPDRLLMLFA LDVLKRNPGA DIIFDVKCTR RLTPLISEHG 300
    GRPVMWKTGH SLIKKEMKKS GALLAGEMSG HIFFKERWFG FDDGIYSAAR 350
    LLEILSQEPA NAEDLFETFP NDISTPEINI KVTDVTKFSI IEALEKDAQW 400
    GDAKLTTIDG VRVDYPKGWG LVRASNTTPV LVLRFEAETQ AELERIQGVF 450
    HAELKKVAPD LDLPF 465
    Length:465
    Mass (Da):50,692
    Last modified:June 1, 2003 - v1
    Checksum:iA078D8A974111C2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016853 Genomic DNA. Translation: AAO53637.1.
    RefSeqiNP_789942.1. NC_004578.1.

    Genome annotation databases

    EnsemblBacteriaiAAO53637; AAO53637; PSPTO_0083.
    GeneIDi1181691.
    KEGGipst:PSPTO_0083.
    PATRICi19991314. VBIPseSyr93040_0087.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016853 Genomic DNA. Translation: AAO53637.1 .
    RefSeqi NP_789942.1. NC_004578.1.

    3D structure databases

    ProteinModelPortali Q88BD4.
    SMRi Q88BD4. Positions 11-465.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 223283.PSPTO_0083.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO53637 ; AAO53637 ; PSPTO_0083 .
    GeneIDi 1181691.
    KEGGi pst:PSPTO_0083.
    PATRICi 19991314. VBIPseSyr93040_0087.

    Phylogenomic databases

    eggNOGi COG1109.
    HOGENOMi HOG000268679.
    KOi K15778.
    OMAi RPMNIAI.
    OrthoDBi EOG6W9X55.
    PhylomeDBi Q88BD4.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00126 ; UER00424 .
    BioCyci PSYR223283:GJIX-83-MONOMER.

    Family and domain databases

    Gene3Di 3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    IPR005841. Alpha-D-phosphohexomutase_SF.
    [Graphical view ]
    Pfami PF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view ]
    PRINTSi PR00509. PGMPMM.
    SUPFAMi SSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEi PS00710. PGM_PMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DC3000.

    Entry informationi

    Entry nameiALGC_PSESM
    AccessioniPrimary (citable) accession number: Q88BD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3