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Reviewed, UniProtKB/Swiss-Prot Q88BD4 (ALGC_PSESM)

Last modified November 3, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Phosphomannomutase/phosphoglucomutase
      Short name=PMM / PGM
    EC=5.4.2.8
    EC=5.4.2.2
Gene names
Name: algC
Ordered Locus Names: PSPTO_0083
OrganismPseudomonas syringae pv. tomato [Complete proteome] [HAMAP]
Taxonomic identifier323 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

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Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production By similarity.

Catalytic activity

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the phosphohexose mutase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Phosphomannomutase/phosphoglucomutase
PRO_0000147816

Sites

Active site1101Phosphoserine intermediate By similarity
Metal binding1101Magnesium; via phosphate group By similarity
Metal binding2441Magnesium By similarity
Metal binding2461Magnesium By similarity
Metal binding2481Magnesium By similarity
Binding site3271Substrate By similarity
Binding site3291Substrate By similarity
Binding site3311Substrate By similarity
Site4231Interacts with the biphosphorylated intermediate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q88BD4-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A078D8A974111C2C

FASTA46550,692
        10         20         30         40         50         60 
MNSPASVAPI LPDTIFRAYD IRGVVEDTLN AETAYWIGRA IGSESLAQNE PNVSVGRDGR 

        70         80         90        100        110        120 
LSGPELVQQL IQGLHDSGCH VSDVGLVPTP ALYYAANVLA GKTGVMLTGS HNPKDYNGFK 

       130        140        150        160        170        180 
IVIAGDTLAN EQIQALHERI KTNNLTSQKG SITQVNILDR YFKQIKDDIV MARKLKVVVD 

       190        200        210        220        230        240 
CGNGAAGVIA PQLIEALGCE VISLFAEVDG NFPNHHPDPG KLENLQDLIA KVKETGADLG 

       250        260        270        280        290        300 
LAFDGDGDRV GVVTNAGNVV YPDRLLMLFA LDVLKRNPGA DIIFDVKCTR RLTPLISEHG 

       310        320        330        340        350        360 
GRPVMWKTGH SLIKKEMKKS GALLAGEMSG HIFFKERWFG FDDGIYSAAR LLEILSQEPA 

       370        380        390        400        410        420 
NAEDLFETFP NDISTPEINI KVTDVTKFSI IEALEKDAQW GDAKLTTIDG VRVDYPKGWG 

       430        440        450        460 
LVRASNTTPV LVLRFEAETQ AELERIQGVF HAELKKVAPD LDLPF

« Hide

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Cross-references

Sequence databases

AE016853 Genomic DNA. Translation: AAO53637.1.
RefSeqNP_789942.1.

3D structure databases

HSSPHSSP built from PDB template 1K2Y based on UniProtKB P26276.
SMRQ88BD4. Positions 11-465.
ModBaseSearch...

Genome annotation databases

GeneID1181691.
GenomeReviewsGene locus PSPTO_0083 in contig AE016853_GR.
KEGGpst:PSPTO_0083.
NMPDRfig|223283.1.peg.80.
TIGRPSPTO_0083.

Phylogenomic databases

HOGENOMQ88BD4.
OMAARPMKIV.

Enzyme and pathway databases

BioCycPSYR223283:PSPTO_0083-MON.
BRENDA5.4.2.2. 289554.
5.4.2.8. 289554.

Family and domain databases

InterProIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. A-D-PHexomutase_N.
[Graphical view]
Gene3DG3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
PfamPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSPR00509. PGMPMM.
PROSITEPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameALGC_PSESM
AccessionPrimary (citable) accession number: Q88BD4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: November 3, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents