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Q88BD4

- ALGC_PSESM

UniProt

Q88BD4 - ALGC_PSESM

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Protein

Phosphomannomutase/phosphoglucomutase

Gene

algC

Organism
Pseudomonas syringae pv. tomato (strain DC3000)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production By similarity.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

Cofactori

Binds 1 magnesium ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei110 – 1101Phosphoserine intermediateBy similarity
Metal bindingi110 – 1101Magnesium; via phosphate groupBy similarity
Metal bindingi244 – 2441MagnesiumBy similarity
Metal bindingi246 – 2461MagnesiumBy similarity
Metal bindingi248 – 2481MagnesiumBy similarity
Binding sitei327 – 3271SubstrateBy similarity
Binding sitei329 – 3291SubstrateBy similarity
Binding sitei331 – 3311SubstrateBy similarity
Sitei423 – 4231Interacts with the biphosphorylated intermediateBy similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. phosphoglucomutase activity Source: UniProtKB-EC
  3. phosphomannomutase activity Source: JCVI

GO - Biological processi

  1. alginic acid biosynthetic process Source: UniProtKB-KW
  2. carbohydrate metabolic process Source: JCVI
  3. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  4. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Alginate biosynthesis, Lipopolysaccharide biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciPSYR223283:GJIX-83-MONOMER.
UniPathwayiUPA00030.
UPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase/phosphoglucomutase (EC:5.4.2.2, EC:5.4.2.8)
Short name:
PMM / PGM
Gene namesi
Name:algC
Ordered Locus Names:PSPTO_0083
OrganismiPseudomonas syringae pv. tomato (strain DC3000)
Taxonomic identifieri223283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002515: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Phosphomannomutase/phosphoglucomutasePRO_0000147816Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi223283.PSPTO_0083.

Structurei

3D structure databases

ProteinModelPortaliQ88BD4.
SMRiQ88BD4. Positions 11-465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiCOG1109.
HOGENOMiHOG000268679.
KOiK15778.
OMAiRPMNIAI.
OrthoDBiEOG6W9X55.
PhylomeDBiQ88BD4.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88BD4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSPASVAPI LPDTIFRAYD IRGVVEDTLN AETAYWIGRA IGSESLAQNE
60 70 80 90 100
PNVSVGRDGR LSGPELVQQL IQGLHDSGCH VSDVGLVPTP ALYYAANVLA
110 120 130 140 150
GKTGVMLTGS HNPKDYNGFK IVIAGDTLAN EQIQALHERI KTNNLTSQKG
160 170 180 190 200
SITQVNILDR YFKQIKDDIV MARKLKVVVD CGNGAAGVIA PQLIEALGCE
210 220 230 240 250
VISLFAEVDG NFPNHHPDPG KLENLQDLIA KVKETGADLG LAFDGDGDRV
260 270 280 290 300
GVVTNAGNVV YPDRLLMLFA LDVLKRNPGA DIIFDVKCTR RLTPLISEHG
310 320 330 340 350
GRPVMWKTGH SLIKKEMKKS GALLAGEMSG HIFFKERWFG FDDGIYSAAR
360 370 380 390 400
LLEILSQEPA NAEDLFETFP NDISTPEINI KVTDVTKFSI IEALEKDAQW
410 420 430 440 450
GDAKLTTIDG VRVDYPKGWG LVRASNTTPV LVLRFEAETQ AELERIQGVF
460
HAELKKVAPD LDLPF
Length:465
Mass (Da):50,692
Last modified:June 1, 2003 - v1
Checksum:iA078D8A974111C2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016853 Genomic DNA. Translation: AAO53637.1.
RefSeqiNP_789942.1. NC_004578.1.

Genome annotation databases

EnsemblBacteriaiAAO53637; AAO53637; PSPTO_0083.
GeneIDi1181691.
KEGGipst:PSPTO_0083.
PATRICi19991314. VBIPseSyr93040_0087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016853 Genomic DNA. Translation: AAO53637.1 .
RefSeqi NP_789942.1. NC_004578.1.

3D structure databases

ProteinModelPortali Q88BD4.
SMRi Q88BD4. Positions 11-465.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223283.PSPTO_0083.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO53637 ; AAO53637 ; PSPTO_0083 .
GeneIDi 1181691.
KEGGi pst:PSPTO_0083.
PATRICi 19991314. VBIPseSyr93040_0087.

Phylogenomic databases

eggNOGi COG1109.
HOGENOMi HOG000268679.
KOi K15778.
OMAi RPMNIAI.
OrthoDBi EOG6W9X55.
PhylomeDBi Q88BD4.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00126 ; UER00424 .
BioCyci PSYR223283:GJIX-83-MONOMER.

Family and domain databases

Gene3Di 3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view ]
Pfami PF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view ]
PRINTSi PR00509. PGMPMM.
SUPFAMi SSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEi PS00710. PGM_PMM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DC3000.

Entry informationi

Entry nameiALGC_PSESM
AccessioniPrimary (citable) accession number: Q88BD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3