Reviewed, UniProtKB/Swiss-Prot Q88AE9 (BETB_PSESM)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Synonyms:	badH
Ordered Locus Names:	PSPTO_0441

Organism

Pseudomonas syringae pv. tomato [Complete proteome] [HAMAP]

Taxonomic identifier

323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_0000056548
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88AE9-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7D249A21B73D3ED3	FASTA	490	53,175
	10 20 30 40 50 60 MARFELQKLY IDGGYVDASN TETFDSINPA NGEVLAKIQR ASKEDVERAV VAAEKGQKIW 70 80 90 100 110 120 AAMTAVERSR ILRRAVDILR ERNDELAALE TLDTGKAISE TRYVDIVTGA DVLEYYAGLV 130 140 150 160 170 180 PAIEGEQIPL RDSSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TSLTTLKLAE IYTEAGVPNG VFNVLTGSGR EVGTWITEHP RIEKVSFTGG TDTGKKVMAS 250 260 270 280 290 300 ASSSSLKEVT MELGGKSPLI VFDDADLDRA ADIAMMANFY SSGQVCTNGT RVFVPNALKG 310 320 330 340 350 360 EFEAKILERV KRIRPGNPED ENINFGPLVS FEHMESVLGY IAKGKEQGAR LLCGGDRLTG 370 380 390 400 410 420 GVFDKGAFVA ATVFTDCTDE MTIVREEIFG PVMSILGYDT EDEVVRRAND TDFGLAAGIV 430 440 450 460 470 480 TRDLNRAHRV IHLLEAGICW INAWGESAAQ MPVGGYKQSG VGRENGISSL AQYTRIKSVQ 490 IELGDYASVF

References

[1]

"The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000." Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T., Gwinn M.L., Dodson R.J., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Daugherty S.C., Brinkac L.M., Beanan M.J., Haft D.H., Nelson W.C., Davidsen T.M., Zafar N. , Zhou L., Liu J., Yuan Q., Khouri H.M., Fedorova N.B., Tran B., Russell D., Berry K.J., Utterback T.R., Van Aken S.E., Feldblyum T.V., D'Ascenzo M., Deng W.-L., Ramos A.R., Alfano J.R., Cartinhour S., Chatterjee A.K., Delaney T.P., Lazarowitz S.G., Martin G.B., Schneider D.J., Tang X., Bender C.L., White O., Fraser C.M., Collmer A. Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003) [PubMed: 12928499] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DC3000.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016853 Genomic DNA. Translation: AAO53985.1.
RefSeq	NP_790290.1.
3D structure databases
HSSP	HSSP built from PDB template 1A4S based on UniProtKB P56533.
ModBase	Search...
Genome annotation databases
GeneID	1182050.
GenomeReviews	Gene locus PSPTO_0441 in contig AE016853_GR.
KEGG	pst:PSPTO_0441.
NMPDR	fig|223283.1.peg.428.
TIGR	PSPTO_0441.
Phylogenomic databases
HOGENOM	Q88AE9.
OMA	Q88AE9. AHRTIHR.
Enzyme and pathway databases
BioCyc	PSYR223283:PSPTO_0441-MON.
BRENDA	1.2.1.8. 289554.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_PSESM

Accession

Primary (citable) accession number: Q88AE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)