Q88AE9 (BETB_PSESM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8

Gene names

Name:	betB
Synonyms:	badH
Ordered Locus Names:	PSPTO_0441

Organism

Pseudomonas syringae pv. tomato (strain DC3000) [Complete proteome] [HAMAP]

Taxonomic identifier

223283 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas syringae group › Pseudomonas syringae group genomosp. 3 › Pseudomonas syringae pv. tomato

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP
Molecular_function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase HAMAP-Rule MF_00804		PRO_0000056548
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88AE9 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7D249A21B73D3ED3	FASTA	490	53,175
	10 20 30 40 50 60 MARFELQKLY IDGGYVDASN TETFDSINPA NGEVLAKIQR ASKEDVERAV VAAEKGQKIW 70 80 90 100 110 120 AAMTAVERSR ILRRAVDILR ERNDELAALE TLDTGKAISE TRYVDIVTGA DVLEYYAGLV 130 140 150 160 170 180 PAIEGEQIPL RDSSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TSLTTLKLAE IYTEAGVPNG VFNVLTGSGR EVGTWITEHP RIEKVSFTGG TDTGKKVMAS 250 260 270 280 290 300 ASSSSLKEVT MELGGKSPLI VFDDADLDRA ADIAMMANFY SSGQVCTNGT RVFVPNALKG 310 320 330 340 350 360 EFEAKILERV KRIRPGNPED ENINFGPLVS FEHMESVLGY IAKGKEQGAR LLCGGDRLTG 370 380 390 400 410 420 GVFDKGAFVA ATVFTDCTDE MTIVREEIFG PVMSILGYDT EDEVVRRAND TDFGLAAGIV 430 440 450 460 470 480 TRDLNRAHRV IHLLEAGICW INAWGESAAQ MPVGGYKQSG VGRENGISSL AQYTRIKSVQ 490 IELGDYASVF

References

[1]

"The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000." Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T., Gwinn M.L., Dodson R.J., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Daugherty S.C., Brinkac L.M., Beanan M.J., Haft D.H., Nelson W.C., Davidsen T.M., Zafar N. , Zhou L., Liu J., Yuan Q., Khouri H.M., Fedorova N.B., Tran B., Russell D., Berry K.J., Utterback T.R., Van Aken S.E., Feldblyum T.V., D'Ascenzo M., Deng W.-L., Ramos A.R., Alfano J.R., Cartinhour S., Chatterjee A.K., Delaney T.P., Lazarowitz S.G., Martin G.B., Schneider D.J., Tang X., Bender C.L., White O., Fraser C.M., Collmer A. Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DC3000.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016853 Genomic DNA. Translation: AAO53985.1.
RefSeq	NP_790290.1. NC_004578.1.
3D structure databases
ProteinModelPortal	Q88AE9.
ModBase	Search...
Protein-protein interaction databases
STRING	223283.PSPTO_0441.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO53985; AAO53985; PSPTO_0441.
GeneID	1182050.
KEGG	pst:PSPTO_0441.
PATRIC	19992066. VBIPseSyr93040_0461.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HOG000271505.
KO	K00130.
OMA	GTDTGKK.
ProtClustDB	PRK13252.
Enzyme and pathway databases
BioCyc	PSYR223283:GJIX-437-MONOMER.
UniPathway	UPA00529; UER00386.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
HAMAP	MF_00804. BADH.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR011264. Betaine_Ald_DH. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_PSESM

Accession

Primary (citable) accession number: Q88AE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program