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Q88AE7

- BETA_PSESM

UniProt

Q88AE7 - BETA_PSESM

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Pseudomonas syringae pv. tomato (strain DC3000)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei477 – 4771UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 3730FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciPSYR223283:GJIX-439-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:PSPTO_0443
OrganismiPseudomonas syringae pv. tomato (strain DC3000)
Taxonomic identifieri223283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002515: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Oxygen-dependent choline dehydrogenasePRO_0000205592Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi223283.PSPTO_0443.

Structurei

3D structure databases

ProteinModelPortaliQ88AE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.
PhylomeDBiQ88AE7.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88AE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTQSEYDYI IIGAGSAGNT LAARLTEDAG VTVLLLEAGG PDYRLDFRTQ
60 70 80 90 100
MPAALAFPLQ GRRYNWAYET EPEPHMDNRR MECGRGKGLG GSSLINGMCY
110 120 130 140 150
IRGNAMDYDG WAKEPGLEDW SYLDCLPYFR KAETRDIGPN DYHGGEGPVS
160 170 180 190 200
VTTPKAGNNP LFHAMVEAGV QAGFPRTDDL NGYQQEGFGP MDRTVTPKGR
210 220 230 240 250
RASTARGYLD EAKKRDTLSI VTHALTDRIL FEGKRAVGVA YLVGDSDTRI
260 270 280 290 300
EVRARKEVLL CGGAIASPQI LQRSGVGPAE VLNKLDIPVV HDLPGVGQNL
310 320 330 340 350
QDHLEMYLQY ACTQPVSLYP SLKWWNQPAI GAEWMFLGTG IGASNQFEAG
360 370 380 390 400
GFIRSSEAFE WPNIQYHFLP VAINYNGTKG VQEHGFQAHV GSMRSPSRGR
410 420 430 440 450
VHVKSKDPRE YPSILFNYMA SDQDWQEFRD GIRLTREIMQ QPALDPYRGR
460 470 480 490 500
EISPGIDVQS DEALDQFVRE HAETAYHPSC SCKMGTDEMA VVDGQGRVHG
510 520 530 540 550
MQNLRVVDAS IMPIITTGNL NAPTIMIAEK IADKIRGRQP LPRSTADYFV
560
AGDKPARGKP LREISHQA
Length:568
Mass (Da):62,788
Last modified:June 1, 2003 - v1
Checksum:i147045C3DDCC9005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA. Translation: AAO53987.1.
RefSeqiNP_790292.1. NC_004578.1.

Genome annotation databases

EnsemblBacteriaiAAO53987; AAO53987; PSPTO_0443.
GeneIDi1182052.
KEGGipst:PSPTO_0443.
PATRICi19992068. VBIPseSyr93040_0462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA. Translation: AAO53987.1 .
RefSeqi NP_790292.1. NC_004578.1.

3D structure databases

ProteinModelPortali Q88AE7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223283.PSPTO_0443.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO53987 ; AAO53987 ; PSPTO_0443 .
GeneIDi 1182052.
KEGGi pst:PSPTO_0443.
PATRICi 19992068. VBIPseSyr93040_0462.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.
PhylomeDBi Q88AE7.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci PSYR223283:GJIX-439-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DC3000.

Entry informationi

Entry nameiBETA_PSESM
AccessioniPrimary (citable) accession number: Q88AE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3