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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei477Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 37FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

  • fermentation Source: JCVI
  • glycine betaine biosynthetic process from choline Source: UniProtKB-UniPathway

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:PSPTO_0443
OrganismiPseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Taxonomic identifieri223283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002515 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002055921 – 568Oxygen-dependent choline dehydrogenaseAdd BLAST568

Interactioni

Protein-protein interaction databases

STRINGi223283.PSPTO_0443.

Structurei

3D structure databases

ProteinModelPortaliQ88AE7.
SMRiQ88AE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ6. Bacteria.
COG2303. LUCA.
HOGENOMiHOG000139600.
KOiK00108.
OMAiGWDYAHC.
OrthoDBiPOG091H04UT.
PhylomeDBiQ88AE7.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen. 1 hit.
InterProiView protein in InterPro
IPR011533. BetA.
IPR023753. FAD/NAD-binding_dom.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
PANTHERiPTHR11552:SF159. PTHR11552:SF159. 1 hit.
PfamiView protein in Pfam
PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiView protein in PROSITE
PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88AE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQSEYDYI IIGAGSAGNT LAARLTEDAG VTVLLLEAGG PDYRLDFRTQ
60 70 80 90 100
MPAALAFPLQ GRRYNWAYET EPEPHMDNRR MECGRGKGLG GSSLINGMCY
110 120 130 140 150
IRGNAMDYDG WAKEPGLEDW SYLDCLPYFR KAETRDIGPN DYHGGEGPVS
160 170 180 190 200
VTTPKAGNNP LFHAMVEAGV QAGFPRTDDL NGYQQEGFGP MDRTVTPKGR
210 220 230 240 250
RASTARGYLD EAKKRDTLSI VTHALTDRIL FEGKRAVGVA YLVGDSDTRI
260 270 280 290 300
EVRARKEVLL CGGAIASPQI LQRSGVGPAE VLNKLDIPVV HDLPGVGQNL
310 320 330 340 350
QDHLEMYLQY ACTQPVSLYP SLKWWNQPAI GAEWMFLGTG IGASNQFEAG
360 370 380 390 400
GFIRSSEAFE WPNIQYHFLP VAINYNGTKG VQEHGFQAHV GSMRSPSRGR
410 420 430 440 450
VHVKSKDPRE YPSILFNYMA SDQDWQEFRD GIRLTREIMQ QPALDPYRGR
460 470 480 490 500
EISPGIDVQS DEALDQFVRE HAETAYHPSC SCKMGTDEMA VVDGQGRVHG
510 520 530 540 550
MQNLRVVDAS IMPIITTGNL NAPTIMIAEK IADKIRGRQP LPRSTADYFV
560
AGDKPARGKP LREISHQA
Length:568
Mass (Da):62,788
Last modified:June 1, 2003 - v1
Checksum:i147045C3DDCC9005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA. Translation: AAO53987.1.
RefSeqiNP_790292.1. NC_004578.1.
WP_005763658.1. NC_004578.1.

Genome annotation databases

EnsemblBacteriaiAAO53987; AAO53987; PSPTO_0443.
GeneIDi1182052.
KEGGipst:PSPTO_0443.
PATRICifig|223283.9.peg.462.

Similar proteinsi

Entry informationi

Entry nameiBETA_PSESM
AccessioniPrimary (citable) accession number: Q88AE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2003
Last modified: August 30, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families