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Q887Q9

- ALGA_PSESM

UniProt

Q887Q9 - ALGA_PSESM

Protein

Alginate biosynthesis protein AlgA

Gene

algA

Organism
Pseudomonas syringae pv. tomato (strain DC3000)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics By similarity.By similarity

    Catalytic activityi

    D-mannose 6-phosphate = D-fructose 6-phosphate.
    GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

    Cofactori

    Cobalt (for PMI).By similarity

    Pathwayi

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. mannose-1-phosphate guanylyltransferase activity Source: UniProtKB-EC
    3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. alginic acid biosynthetic process Source: UniProtKB-KW
    2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Alginate biosynthesis

    Keywords - Ligandi

    Cobalt, GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPSYR223283:GJIX-1257-MONOMER.
    UniPathwayiUPA00126; UER00423.
    UPA00126; UER00930.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alginate biosynthesis protein AlgA
    Including the following 2 domains:
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Alternative name(s):
    Phosphohexomutase
    Phosphomannose isomerase
    Short name:
    PMI
    Mannose-1-phosphate guanylyltransferase (EC:2.7.7.13)
    Alternative name(s):
    GDP-mannose pyrophosphorylase
    Short name:
    GMP
    Short name:
    GMPP
    GTP--mannose-1-phosphate guanylyltransferase
    Gene namesi
    Name:algA
    Ordered Locus Names:PSPTO_1232
    OrganismiPseudomonas syringae pv. tomato (strain DC3000)
    Taxonomic identifieri223283 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002515: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Alginate biosynthesis protein AlgAPRO_0000194251Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi223283.PSPTO_1232.

    Structurei

    3D structure databases

    ProteinModelPortaliQ887Q9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0662.
    HOGENOMiHOG000153549.
    KOiK16011.
    OMAiELKKHDP.
    OrthoDBiEOG6X3W6T.
    PhylomeDBiQ887Q9.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    3.90.550.10. 1 hit.
    InterProiIPR006375. Man1P_GuaTrfase/Man6P_Isoase.
    IPR001538. Man6P_isomerase-2_C.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF01050. MannoseP_isomer. 1 hit.
    PF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    SSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01479. GMP_PMI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q887Q9-1 [UniParc]FASTAAdd to Basket

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    MIPVILSGGS GSRLWPLSRK QFPKQFLALT GEHTLFQQTL QRLVFEGMQE    50
    PIVVCNKDHR FIVNEQLAAL NLETQAILME PFGRNTAPAV ALTAMKLVNE 100
    GNDGLMLVLP ADHVIEDQKA LQRALALATV TAERGEMVLF GVPANKPETG 150
    YGYIKSTADA LLPEGVSRVS QFVEKPDEKR AKEFVEAGGY YWNSGMFLFR 200
    ASRFLEELKK HDPDIYDTCL LTLERSVQDG DALEIDASTF ACCPDNSIDY 250
    AVMEKTQRAC VVPLSAGWSD VGCWSSLWEV NAKDAHGNVT KGDVVIQDSR 300
    NCMIHGNGKL VSVIGLDNIV VVETKDAMMI AHKDKVQGVK QMVATLNEQG 350
    RTETQNHLEV YRPWGSYDSV DMGGRFQVKR ISVKPGACLS LQMHHHRAEH 400
    WIVVSGTAQV TCDENVFLLT ENQSTYIPIA SVHRLRNPGK IPLEIIEVQS 450
    GSYLGEDDIE RFEDIYGRSN ALEAGVKTQT IAR 483
    Length:483
    Mass (Da):53,563
    Last modified:June 1, 2003 - v1
    Checksum:iB9EFCA39C452FE44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016853 Genomic DNA. Translation: AAO54757.1.
    RefSeqiNP_791062.1. NC_004578.1.

    Genome annotation databases

    EnsemblBacteriaiAAO54757; AAO54757; PSPTO_1232.
    GeneIDi1182868.
    KEGGipst:PSPTO_1232.
    PATRICi19993704. VBIPseSyr93040_1253.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016853 Genomic DNA. Translation: AAO54757.1 .
    RefSeqi NP_791062.1. NC_004578.1.

    3D structure databases

    ProteinModelPortali Q887Q9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 223283.PSPTO_1232.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO54757 ; AAO54757 ; PSPTO_1232 .
    GeneIDi 1182868.
    KEGGi pst:PSPTO_1232.
    PATRICi 19993704. VBIPseSyr93040_1253.

    Phylogenomic databases

    eggNOGi COG0662.
    HOGENOMi HOG000153549.
    KOi K16011.
    OMAi ELKKHDP.
    OrthoDBi EOG6X3W6T.
    PhylomeDBi Q887Q9.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00423 .
    UPA00126 ; UER00930 .
    BioCyci PSYR223283:GJIX-1257-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    3.90.550.10. 1 hit.
    InterProi IPR006375. Man1P_GuaTrfase/Man6P_Isoase.
    IPR001538. Man6P_isomerase-2_C.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF01050. MannoseP_isomer. 1 hit.
    PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01479. GMP_PMI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DC3000.

    Entry informationi

    Entry nameiALGA_PSESM
    AccessioniPrimary (citable) accession number: Q887Q9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3