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Q887Q9 (ALGA_PSESM) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alginate biosynthesis protein AlgA

Including the following 2 domains:

  1. Mannose-6-phosphate isomerase
    EC=5.3.1.8
    Alternative name(s):
    Phosphohexomutase
    Phosphomannose isomerase
    Short name=PMI
  2. Mannose-1-phosphate guanylyltransferase
    EC=2.7.7.13
    Alternative name(s):
    GDP-mannose pyrophosphorylase
    Short name=GMP
    Short name=GMPP
    GTP--mannose-1-phosphate guanylyltransferase
Gene names
Name:algA
Ordered Locus Names:PSPTO_1232
OrganismPseudomonas syringae pv. tomato (strain DC3000) [Complete proteome] [HAMAP]
Taxonomic identifier223283 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics By similarity.

Catalytic activity

D-mannose 6-phosphate = D-fructose 6-phosphate.

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

Cofactor

Cobalt (for PMI) By similarity.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannose-6-phosphate isomerase type 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Alginate biosynthesis protein AlgA
PRO_0000194251

Sequences

Sequence LengthMass (Da)Tools
Q887Q9 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B9EFCA39C452FE44

FASTA48353,563
        10         20         30         40         50         60 
MIPVILSGGS GSRLWPLSRK QFPKQFLALT GEHTLFQQTL QRLVFEGMQE PIVVCNKDHR 

        70         80         90        100        110        120 
FIVNEQLAAL NLETQAILME PFGRNTAPAV ALTAMKLVNE GNDGLMLVLP ADHVIEDQKA 

       130        140        150        160        170        180 
LQRALALATV TAERGEMVLF GVPANKPETG YGYIKSTADA LLPEGVSRVS QFVEKPDEKR 

       190        200        210        220        230        240 
AKEFVEAGGY YWNSGMFLFR ASRFLEELKK HDPDIYDTCL LTLERSVQDG DALEIDASTF 

       250        260        270        280        290        300 
ACCPDNSIDY AVMEKTQRAC VVPLSAGWSD VGCWSSLWEV NAKDAHGNVT KGDVVIQDSR 

       310        320        330        340        350        360 
NCMIHGNGKL VSVIGLDNIV VVETKDAMMI AHKDKVQGVK QMVATLNEQG RTETQNHLEV 

       370        380        390        400        410        420 
YRPWGSYDSV DMGGRFQVKR ISVKPGACLS LQMHHHRAEH WIVVSGTAQV TCDENVFLLT 

       430        440        450        460        470        480 
ENQSTYIPIA SVHRLRNPGK IPLEIIEVQS GSYLGEDDIE RFEDIYGRSN ALEAGVKTQT 


IAR 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016853 Genomic DNA. Translation: AAO54757.1.
RefSeqNP_791062.1. NC_004578.1.

3D structure databases

ProteinModelPortalQ887Q9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING223283.PSPTO_1232.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO54757; AAO54757; PSPTO_1232.
GeneID1182868.
KEGGpst:PSPTO_1232.
PATRIC19993704. VBIPseSyr93040_1253.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0662.
HOGENOMHOG000153549.
KOK16011.
OMAELKKHDP.
OrthoDBEOG6X3W6T.
PhylomeDBQ887Q9.

Enzyme and pathway databases

BioCycPSYR223283:GJIX-1257-MONOMER.
UniPathwayUPA00126; UER00423.
UPA00126; UER00930.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
3.90.550.10. 1 hit.
InterProIPR006375. Man1P_GuaTrfase/Man6P_Isoase.
IPR001538. Man6P_isomerase-2_C.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF01050. MannoseP_isomer. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
SSF53448. SSF53448. 1 hit.
TIGRFAMsTIGR01479. GMP_PMI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameALGA_PSESM
AccessionPrimary (citable) accession number: Q887Q9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways