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Q887L5

- GCSP_PSESM

UniProt

Q887L5 - GCSP_PSESM

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, PSPTO_1276
Organism
Pseudomonas syringae pv. tomato (strain DC3000)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPSYR223283:GJIX-1301-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:PSPTO_1276
OrganismiPseudomonas syringae pv. tomato (strain DC3000)
Taxonomic identifieri223283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002515: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166929Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei706 – 7061N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi223283.PSPTO_1276.

Structurei

3D structure databases

ProteinModelPortaliQ887L5.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ887L5.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q887L5-1 [UniParc]FASTAAdd to Basket

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MTDRIELTTA NEFIARHIGP RAADELAMLH TLGFDSIEAL SDSVIPESIK    50
GTSVLNLPAG QSEADALASI KAIASKNQLF KTYIGQGYYN THTPAPILRN 100
LLENPAWYTA YTPYQPEISQ GRLESLLNFQ TLISDLTGLP IANASLLDEA 150
TAAAEAMTFC KRLSKNKGSQ QFFASSHCHP QTLDVLRTRA EPLGITVVVA 200
DETELGDVSD YFGALLQYPA SNGDVFDYRE LAERFHGANA LVAVAADLLA 250
LTLLTPPGEF GADVAIGSAQ RFGVPLGFGG PHAAYFSTRD AFKRDMPGRL 300
VGVSVDRHGK QALRLAMQTR EQHIRREKAT SNICTAQVLL ANIASMYAVY 350
HGPRGLTQIA NRVHHLTAIL AEGLSQLGLN AEQAYFFDSL TLHTGGRTAA 400
LHAAARARHI NLREIDDQRL GLSLDETTSQ SAVEVLWDIF ASTGQTLPDF 450
TALAASVKSR LPAALLRQSA ILSHPVFNRY HSETELMRYL RKLADKDLAL 500
DRTMIPLGSC TMKLNAASEM IPVTWAEFGN LHPFAPAEQS AGYQQLTDEL 550
EAMLCAATGY DAISLQPNAG SQGEYAGLLA IRAYHQSRGD EHRDICLIPS 600
SAHGTNPATA NMAGMRVVVT ACDARGNVDI EDLRAKALQH REQLAAIMIT 650
YPSTHGVFEE GIREICGIVH DNGGQVYIDG ANMNAMVGLC APGKFGGDVS 700
HLNLHKTFCI PHGGGGPGVG PIGVKSHLAP FMPGHARMQR KEGAVCAAPF 750
GSASILPITW MYIRMMGGEG LKRASQLAIL NANYISRRLE EHYPVLYTGT 800
NGLVAHECIL DLRPIKDSSG ISVDDVAKRL IDFGFHAPTM SFPVAGTLMI 850
EPTESESREE LDRFCDAMIK IREEIRAVED GTLDKDDNPL KNAPHTAAEI 900
VGQWSHPYSR EQAVYPVDSL IENKYWPPVG RVDNVFGDRN LVCACPSIES 950
YQEA 954
Length:954
Mass (Da):103,604
Last modified:June 1, 2003 - v1
Checksum:i503D639E9F6A16A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016853 Genomic DNA. Translation: AAO54801.1.
RefSeqiNP_791106.1. NC_004578.1.

Genome annotation databases

EnsemblBacteriaiAAO54801; AAO54801; PSPTO_1276.
GeneIDi1182912.
KEGGipst:PSPTO_1276.
PATRICi19993794. VBIPseSyr93040_1298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016853 Genomic DNA. Translation: AAO54801.1 .
RefSeqi NP_791106.1. NC_004578.1.

3D structure databases

ProteinModelPortali Q887L5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 223283.PSPTO_1276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO54801 ; AAO54801 ; PSPTO_1276 .
GeneIDi 1182912.
KEGGi pst:PSPTO_1276.
PATRICi 19993794. VBIPseSyr93040_1298.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.
PhylomeDBi Q887L5.

Enzyme and pathway databases

BioCyci PSYR223283:GJIX-1301-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DC3000.

Entry informationi

Entry nameiGCSP_PSESM
AccessioniPrimary (citable) accession number: Q887L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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