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Protein

Pterin-4-alpha-carbinolamine dehydratase

Gene

phhB

Organism
Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA (By similarity).By similarity

Catalytic activityi

(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Tetrahydrobiopterin biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Pterin-4-alpha-carbinolamine dehydratase (EC:4.2.1.96UniRule annotation)
Short name:
PHSUniRule annotation
Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydrataseUniRule annotation
Pterin carbinolamine dehydrataseUniRule annotation
Short name:
PCDUniRule annotation
Gene namesi
Name:phhB
Ordered Locus Names:PSPTO_1821
OrganismiPseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Taxonomic identifieri223283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002515 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000630671 – 118Pterin-4-alpha-carbinolamine dehydrataseAdd BLAST118

Interactioni

Protein-protein interaction databases

STRINGi223283.PSPTO_1821.

Structurei

3D structure databases

ProteinModelPortaliQ885L1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pterin-4-alpha-carbinolamine dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41090A4. Bacteria.
COG2154. LUCA.
HOGENOMiHOG000007681.
KOiK01724.
OMAiILTEWGK.
OrthoDBiPOG091H05H0.
PhylomeDBiQ885L1.

Family and domain databases

Gene3Di3.30.1360.20. 1 hit.
HAMAPiMF_00434. Pterin_4_alpha. 1 hit.
InterProiIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERiPTHR12599. PTHR12599. 1 hit.
PfamiPF01329. Pterin_4a. 1 hit.
[Graphical view]
SUPFAMiSSF55248. SSF55248. 1 hit.

Sequencei

Sequence statusi: Complete.

Q885L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLNQAHCE ACSAGAPQVS EAELPELLRQ IPDWNIEVRD SVMQLEKVFL
60 70 80 90 100
FKNFKFALAF TNAVGEIAEA EGHHPGLLTE WGKVTVTWWS HSIKGLHRND
110
FIMAARTDEV AAKAEGRK
Length:118
Mass (Da):13,176
Last modified:June 1, 2003 - v1
Checksum:iFD5CF845B10FE25A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA. Translation: AAO55340.1.
RefSeqiNP_791645.1. NC_004578.1.
WP_005616592.1. NC_004578.1.

Genome annotation databases

EnsemblBacteriaiAAO55340; AAO55340; PSPTO_1821.
GeneIDi1183462.
KEGGipst:PSPTO_1821.
PATRICi19994908. VBIPseSyr93040_1851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA. Translation: AAO55340.1.
RefSeqiNP_791645.1. NC_004578.1.
WP_005616592.1. NC_004578.1.

3D structure databases

ProteinModelPortaliQ885L1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi223283.PSPTO_1821.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO55340; AAO55340; PSPTO_1821.
GeneIDi1183462.
KEGGipst:PSPTO_1821.
PATRICi19994908. VBIPseSyr93040_1851.

Phylogenomic databases

eggNOGiENOG41090A4. Bacteria.
COG2154. LUCA.
HOGENOMiHOG000007681.
KOiK01724.
OMAiILTEWGK.
OrthoDBiPOG091H05H0.
PhylomeDBiQ885L1.

Family and domain databases

Gene3Di3.30.1360.20. 1 hit.
HAMAPiMF_00434. Pterin_4_alpha. 1 hit.
InterProiIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERiPTHR12599. PTHR12599. 1 hit.
PfamiPF01329. Pterin_4a. 1 hit.
[Graphical view]
SUPFAMiSSF55248. SSF55248. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHS_PSESM
AccessioniPrimary (citable) accession number: Q885L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.