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Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Pseudomonas syringae pv. tomato (strain DC3000)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transforms N(2)-succinylglutamate into succinate and glutamate.UniRule annotation

Catalytic activityi

N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591ZincUniRule annotation
Metal bindingi62 – 621ZincUniRule annotation
Metal bindingi151 – 1511ZincUniRule annotation
Active sitei215 – 2151UniRule annotation

GO - Molecular functioni

  1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP
  2. succinylglutamate desuccinylase activity Source: UniProtKB-EC
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
  2. arginine catabolic process to succinate Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciPSYR223283:GJIX-1873-MONOMER.
UniPathwayiUPA00185; UER00283.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinylglutamate desuccinylaseUniRule annotation (EC:3.5.1.96UniRule annotation)
Gene namesi
Name:astEUniRule annotation
Ordered Locus Names:PSPTO_1838
OrganismiPseudomonas syringae pv. tomato (strain DC3000)
Taxonomic identifieri223283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002515: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Succinylglutamate desuccinylasePRO_0000174645Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi223283.PSPTO_1838.

Structurei

3D structure databases

ProteinModelPortaliQ885J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2988.
HOGENOMiHOG000280300.
KOiK05526.
OMAiFPNPNVA.
OrthoDBiEOG613070.
PhylomeDBiQ885J4.

Family and domain databases

HAMAPiMF_00767. Arg_catab_AstE.
InterProiIPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
PIRSFiPIRSF017020. AstE. 1 hit.
TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q885J4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLALGKLLEL TLAGREPAEK TQLTVEGVRM RWLAEGALEV RPPQARDNGT
60 70 80 90 100
DLLLSAGIHG NETAPIELLD ELIRSIARGD LKPRARILFL FGNPAAMRLG
110 120 130 140 150
ARYVEQDVNR LFNGRHEQSG GAEALRACEL ERLAASFFSL PDRYRLHYDL
160 170 180 190 200
HTAIRGSKIE QFALYPWKEG RQHSRFELAR LRAAGISAVL LQNKPSIVFS
210 220 230 240 250
AYTYEQLGAE AFTLELGKAR PFGQNRHVNL APLRLRLEQI IEGSEPQPDE
260 270 280 290 300
RLEGLQLFSV AREVIKRSDA FTFNLADDVE NFSELEKGYV LAEDVSDSRW
310 320 330
VVKEEGARII FPNPKVKNGL RAGIVIVPAD ADGLG
Length:335
Mass (Da):37,375
Last modified:June 1, 2003 - v1
Checksum:iE43CFD5829B97F3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA. Translation: AAO55357.1.
RefSeqiNP_791662.1. NC_004578.1.

Genome annotation databases

EnsemblBacteriaiAAO55357; AAO55357; PSPTO_1838.
GeneIDi1183479.
KEGGipst:PSPTO_1838.
PATRICi19994942. VBIPseSyr93040_1868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA. Translation: AAO55357.1.
RefSeqiNP_791662.1. NC_004578.1.

3D structure databases

ProteinModelPortaliQ885J4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi223283.PSPTO_1838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO55357; AAO55357; PSPTO_1838.
GeneIDi1183479.
KEGGipst:PSPTO_1838.
PATRICi19994942. VBIPseSyr93040_1868.

Phylogenomic databases

eggNOGiCOG2988.
HOGENOMiHOG000280300.
KOiK05526.
OMAiFPNPNVA.
OrthoDBiEOG613070.
PhylomeDBiQ885J4.

Enzyme and pathway databases

UniPathwayiUPA00185; UER00283.
BioCyciPSYR223283:GJIX-1873-MONOMER.

Family and domain databases

HAMAPiMF_00767. Arg_catab_AstE.
InterProiIPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
PIRSFiPIRSF017020. AstE. 1 hit.
TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DC3000.

Entry informationi

Entry nameiASTE_PSESM
AccessioniPrimary (citable) accession number: Q885J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.