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Protein
Submitted name:

Gag-pol polyprotein

Gene

gag-pol

Organism
Snakehead retrovirus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseSAAS annotation, Hydrolase, Nuclease, Nucleotidyltransferase, ProteaseSAAS annotation, RNA-directed DNA polymeraseSAAS annotation, Transferase

Keywords - Biological processi

DNA integrationSAAS annotation, DNA recombinationSAAS annotation

Keywords - Ligandi

MagnesiumSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Gag-pol polyproteinImported
Gene namesi
Name:gag-polImported
OrganismiSnakehead retrovirusImported
Taxonomic identifieri40270 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeunclassified Orthoretrovirinae

Subcellular locationi

  • Virion SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

VirionSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ88285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini537 – 55014CCHC-typeInterPro annotationAdd
BLAST
Domaini829 – 1015187Reverse transcriptaseInterPro annotationAdd
BLAST
Domaini1287 – 1406120RNase HInterPro annotationAdd
BLAST
Domaini1674 – 1839166Integrase catalyticInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili142 – 16928Sequence analysisAdd
BLAST
Coiled coili181 – 22949Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 reverse transcriptase domain.UniRule annotation
Contains RNase H domain.SAAS annotation
Contains integrase catalytic domain.SAAS annotation
Contains peptidase A2 domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerUniRule annotationSAAS annotation

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR001584. Integrase_cat-core.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNKWFVYS DEPTKVILKR DKSKEKDETK KKKIKTEQNS DAAYETPGTA
60 70 80 90 100
PVQKPLLETT PEAELEKVLK GLEEWGYKAL EKKRDPELWN PNQEGLDEYL
110 120 130 140 150
FRGWVQGGLA DSKKALEKNM EKFVPLFVVT MSQAVPYWRQ TMQARNQNGK
160 170 180 190 200
KQKNRIAELE KEVADLTSAG RGADQVIAGM DKELKKTAEK YQAKLEELEE
210 220 230 240 250
QLAAMTVEKE ELESQVEGLK ESLVEAETKK VSLMEVLTMP TRSKGPKKRG
260 270 280 290 300
PDLKQIRSLH VMADSLGMDS DGIDWDWLAR QAWDYEGDED PHVKEAEEEA
310 320 330 340 350
WRERQTSQPS QPSQLRPFVA AGNGHREDQW RPLTVTELPA AVTAVGGAWD
360 370 380 390 400
PTRETGSARW KKIVKAAEAI GWGTGDVCQV VTAMSPSWAD VPPEIRNRVA
410 420 430 440 450
TEKEIKAWLM KQGPGGGQGL LEFTKLRQGP TENPSNYLEK ALELYLDSQP
460 470 480 490 500
GDRDGNKDDP AFLQQATQGL LPWLKKAVIL GGKNTSWQEM TSFCQRLWLV
510 520 530 540 550
RDQFADKTGV SKARPIVRNE GPRPQQGHSK IVFGGNCRNC GKAGHMARDC
560 570 580 590 600
WAKGGGQEGK GPRQNTTWKP KSGAIASAPP AESPYADCAK QLADIEKRLK
610 620 630 640 650
DLTTAGGGPK GPNPFHKPXG VAALAAPLCS LKGRPHVSVE IEGHKIECLV
660 670 680 690 700
DTGAEVSLTS LQLQAQRFEQ VVGLGGKPVR VGIADHVDTT VGQVKGKGCW
710 720 730 740 750
RISQELAENI LGNDLLRSLG LIVDQCNGVL WQASEGLGPD NWMAAETLRI
760 770 780 790 800
YSIKSPGHYN LPELLATKDE QLADILWNNV EAFATHRNDC GNLQGMTASF
810 820 830 840 850
TADHPKMIKQ YPVPDASHAS IKETVEALLE QGVLRKCNST VNSAIWPVGK
860 870 880 890 900
PDGSWRLTID YRPLNSAVSC PYPTVASTPE LFAKLEKKYQ VYSSLDISNG
910 920 930 940 950
FWSIRLEEEC QYLFAFTFDT QQYTWTRLPQ GFHASPGIFH QALYNGLASC
960 970 980 990 1000
KTAIESQGCK LLQYVDDILL MSEDRDHHLR SLAILLQGLK DLGVKINPKK
1010 1020 1030 1040 1050
SHFCKDQVQY LGVNVGADTR SLIDARSQLI RTLDIPLTVQ GLRSALGLFN
1060 1070 1080 1090 1100
FCRAWIPEFS RKTQSLYDML KGDCKSTDKL KWTEDNLNKF KLLKDEVASA
1110 1120 1130 1140 1150
CVLGLPDPTL PFRHLIGIRQ GHFLCSLVQK DDNGMWHVLG FYSRKMTPVE
1160 1170 1180 1190 1200
SNLGICEQYA ECAAWAISAC NLVSGFGRKI IVTSHSPVKF ILQTTPNVSN
1210 1220 1230 1240 1250
QRLARWHRIL TQEDITIETD ASIQGWFVPE PYEGEQHQCR PHDDTITWRV
1260 1270 1280 1290 1300
STRAMPTGEK WWIDGSRYWD HDKGGYVTGW AALREDKKNQ LGGALEGHVS
1310 1320 1330 1340 1350
AQVAELVALR EALRLQRPLT LYTDSTYVLG ICTKYLAVWK RRGMVNADGS
1360 1370 1380 1390 1400
QISNQNILQE IWQLIEHDST QTLGIVKVKA HTQRKCSTHE QQLNNDVDQP
1410 1420 1430 1440 1450
AKQYAKEEPN MSVIAPLQVY PLWIGLVPCK EPKLWENIQH HITKVDLPDF
1460 1470 1480 1490 1500
QKQLAEIMPQ QDISHCTLAY FDKPSPEATK YHDKIKPYLG KGQQLTLCDT
1510 1520 1530 1540 1550
YIGKEGAAIL GQLRPDMQAL HQAEGEVHVS LGTRAGHCPQ ELGTMLTNLL
1560 1570 1580 1590 1600
KSTQERIWQD PPVFKLHDET GKVQGYVIKT TLGMKTWIMN DHLVTQSEQT
1610 1620 1630 1640 1650
EGRAKLSSTE GYALAQQYHH LYGHPSEESL RKVLTKRFVW EDMGQHCKEI
1660 1670 1680 1690 1700
TNTCLTCAKY KVLRAGPPMG VGRSAEGPCQ KLQVDHVGPL GPGTHGYRYL
1710 1720 1730 1740 1750
TTMVDVYTGW FWAKPCRGPT TGATIAALEE HISIWGVPYS IQSDNGTAFT
1760 1770 1780 1790 1800
SKAMQEWANT YGIEWKVGAI YHPQSQGKVE RKHRLLKDRL KRATHEGKNW
1810 1820 1830 1840 1850
VQALPSILLF INSMHPRDQF SAYELMTGRV PHLGGYHPHP LETAKEEEVR
1860 1870 1880 1890 1900
IFLRATHDCM QNKKWEEQLE KVTKAEAHSH WTQRSPNLEP GCIVLVRKFT
1910 1920 1930 1940 1950
GDAFSPKWEG PYVITETTKY AAKVQAMSDK VTQHSGWIHR THLVLFPSQN
1960 1970 1980 1990 2000
KRWADPGNPG NQPDEDCTGK KGTVSTADMS PTTSTTRDRG INMGTEQTHR
2010
RRSPRFQRGS DSPSGGQ
Length:2,017
Mass (Da):226,025
Last modified:November 1, 1996 - v1
Checksum:i9D2DA4B81A681CFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26458 Genomic RNA. Translation: AAC54861.1.
RefSeqiNP_043924.1. NC_001724.1.

Genome annotation databases

GeneIDi1403611.
KEGGivg:1403611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26458 Genomic RNA. Translation: AAC54861.1.
RefSeqiNP_043924.1. NC_001724.1.

3D structure databases

ProteinModelPortaliQ88285.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1403611.
KEGGivg:1403611.

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR001584. Integrase_cat-core.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete nucleotide sequence and transcriptional analysis of snakehead fish retrovirus."
    Hart D., Frerichs G.N., Rambaut A., Onions D.E.
    J. Virol. 70:3606-3616(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ88285_9RETR
AccessioniPrimary (citable) accession number: Q88285
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzymeSAAS annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.