Q88261 (HN_SENDO) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 82.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Hemagglutinin-neuraminidase Short name=HN protein Short name=Protein HANA EC=3.2.1.18 | ||
| Gene names |
| ||
| Organism | Sendai virus (strain Ohita) (SeV) [Reference proteome] | ||
| Taxonomic identifier | 302272 [NCBI] | ||
| Taxonomic lineage | Viruses › ssRNA negative-strand viruses › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Respirovirus ›  | ||
| Virus host | Cavia cutleri (Guinea pig) [TaxID: 10144] Cricetidae sp. (Hamster) [TaxID: 36483] Mus musculus (Mouse) [TaxID: 10090] Rattus norvegicus (Rat) [TaxID: 10116] |
Protein attributes
| Sequence length | 575 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity. Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity. |
| Catalytic activity | Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. |
| Subunit structure | Homotetramer; composed of disulfide-linked homodimers. Interacts with F protein trimer By similarity. |
| Subcellular location | Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential. Note: Folded in the endoplasmic reticulum By similarity. |
| Post-translational modification | N-glycosylated; glycans consist of a mixture of high mannose-type oligosaccharides and of complex-type oligosaccharides By similarity. |
| Sequence similarities | Belongs to the paramyxoviruses hemagglutinin-neuraminidase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 575 | 575 | Hemagglutinin-neuraminidase | PRO_0000142639 | |||||
Regions | |||||||||
| Topological domain | 1 – 37 | 37 | Intravirion By similarity | ||||||
| Transmembrane | 38 – 58 | 21 | Helical; By similarity | ||||||
| Topological domain | 59 – 575 | 517 | Virion surface By similarity | ||||||
| Region | 10 – 14 | 5 | Incorporation in virion By similarity | ||||||
| Region | 59 – 140 | 82 | Involved in interaction with F protein By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 77 | 1 | N-linked (GlcNAc...); by host By similarity | ||||||
| Glycosylation | 499 | 1 | N-linked (GlcNAc...); by host By similarity | ||||||
| Glycosylation | 511 | 1 | N-linked (GlcNAc...); by host By similarity | ||||||
| Disulfide bond | 129 | Interchain Potential | |||||||
Natural variations | |||||||||
| Natural variant | 123 | 1 | R → Q in strain: Isolate vaccinal MVCES1. | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "A protease activation mutant, MVCES1, as a safe and potent live vaccine derived from currently prevailing Sendai virus." Wang X.-L., Itoh M., Hotta H., Homma M. J. Virol. 68:3369-3373(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: Isolate vaccinal MVCES1. |
| [2] | "Isolation of an avirulent mutant of Sendai virus with two amino acid mutations from a highly virulent field strain through adaptation to LLC-MK2 cells." Itoh M., Isegawa Y., Hotta H., Homma M. J. Gen. Virol. 78:3207-3215(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: Isolate MVC11. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D26475 Genomic RNA. Translation: BAA05487.1. AB005795 Genomic RNA. Translation: BAA24391.1. AB005796 Genomic RNA. Translation: BAA24400.1. |
| RefSeq | NP_056878.1. NC_001552.1. |
3D structure databases | |
| ProteinModelPortal | Q88261. |
| SMR | Q88261. Positions 144-572. |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GH83. Glycoside Hydrolase Family 83. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1489776. |
Family and domain databases | |
| Gene3D | 2.120.10.10. 1 hit. |
| InterPro | IPR000665. Hemagglutn-neuramid. IPR016285. Hemagglutn-neuramid_paramyxo. IPR011040. Sialidases. [Graphical view] |
| Pfam | PF00423. HN. 1 hit. [Graphical view] |
| PIRSF | PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit. |
| SUPFAM | SSF50939. Sialidase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HN_SENDO | ||||||||
| Accession | Primary (citable) accession number: Q88261 Secondary accession number(s): O57288 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Viral Protein Annotation Program | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| SIMILARITY comments Index of protein domains and families |