Vpr - Simian-Human immunodeficiency virus

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Q88017 (Q88017_9PLVG) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 58. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Vpr EMBL AAB99962.1

Submitted name:
Vpr protein EMBL AAD12138.1

Gene names

Name:

vpr EMBL AAD12138.1

Organism

Simian-Human immunodeficiency virus EMBL AAD12138.1

Taxonomic identifier

57667 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group › unclassified Primate lentivirus group

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Biological process	Cell cycle SAAS SAAS000012 Host-virus interaction SAAS SAAS000012 Initiation of viral infection Transcription Transcription regulation SAAS SAAS000012 Viral penetration into host nucleus SAAS SAAS000012
Cellular component	Host nucleus SAAS SAAS000012 Virion SAAS SAAS000012
Disease	AIDS SAAS SAAS000012 RuleBase RU003343
Molecular function	Activator SAAS SAAS000012
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral infectious cycle Inferred from electronic annotation. Source: InterPro
Cellular component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-KW virion Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q88017 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 802D9539AC2D72E4
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FASTA

101

11,446

        10         20         30         40         50         60 
MEERPPENEG PQREPWDEWV VEVLEELKEE ALKHFDPRLL TALGNHIYNR HGDTLEGAGE 

        70         80         90        100 
LIRILQRALF MHFRGGCIHS RIGQPGGGNP LSAIPPSRSM L

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References

[1]	"Viral outcome of simian-human immunodeficiency virus SHIV-89.6P adapted to cynomolgus monkeys." Borsetti A., Baroncelli S., Maggiorella M.T., Bellino S., Moretti S., Sernicola L., Belli R., Ridolfi B., Farcomeni S., Negri D.R., Cafaro A., Ensoli B., Titti F. Arch. Virol. 153:463-472(2008) [PubMed: 18080858] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SHIV-89.6Pcy243 EMBL ABS11165.1.
[2]	"Derivation and biological characterization of a molecular clone of SHIV(KU-2) that causes AIDS, neurological disease, and renal disease in rhesus macaques." Liu Z.Q., Muhkerjee S., Sahni M., McCormick-Davis C., Leung K., Li Z., Gattone V.H.II., Tian C., Doms R.W., Hoffman T.L., Raghavan R., Narayan O., Stephens E.B. Virology 260:295-307(1999) [PubMed: 10417264] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SHIVku2 EMBL AAV28698.1.
[3]	"A noninfectious simian/human immunodeficiency virus DNA vaccine that protects macaques against AIDS." Singh D.K., Liu Z., Sheffer D., Mackay G.A., Smith M., Dhillon S., Hegde R., Jia F., Adany I., Narayan O. J. Virol. 79:3419-3428(2005) [PubMed: 15731236] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SHIVku2 EMBL AAV28698.1.
[4]	"An env gene derived from a primary human immunodeficiency virus type 1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys." Reimann K.A., Li J.T., Voss G., Lekutis C., Tenner-Racz K., Racz P., Lin W., Montefiori D.C., Lee-Parritz D.E., Lu Y., Collman R.G., Sodroski J., Letvin N.L. J. Virol. 70:3198-3206(1996) [PubMed: 8627800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SHIV-89.6 EMBL AAB99962.1.
[5]	"Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that expresses the HIV-1 envelope glycoproteins." Li J., Lord C.I., Haseltine W., Letvin N.L., Sodroski J. J. Acquir. Immune Defic. Syndr. 5:639-646(1992) [PubMed: 1613662] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SHIV-4 EMBL AAB99972.1.
[6]	"Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys." Karlsson G.B., Halloran M., Li J., Park I.W., Gomila R., Reimann K.A., Axthelm M.K., Iliff S.A., Letvin N.L., Sodroski J. J. Virol. 71:4218-4225(1997) [PubMed: 9151808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SHIV-89.6P EMBL AAC57423.1.
[7]	"Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2)." Cayabyab M., Karlsson G.B., Etemad-Moghadam B.A., Hofmann W., Steenbeke T., Halloran M., Fanton J.W., Axthelm M.K., Letvin N.L., Sodroski J.G. J. Virol. 73:976-984(1999) [PubMed: 9882298] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[8]	"Rapid dissemination of a pathogenic simian/human immunodeficiency virus to systemic organs and active replication in lymphoid tissues following intrarectal infection." Miyake A., Ibuki K., Enose Y., Suzuki H., Horiuchi R., Motohara M., Saito N., Nakasone T., Honda M., Watanabe T., Miura T., Hayami M. J. Gen. Virol. 87:1311-1320(2006) [PubMed: 16603534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SHIV-C2/1 EMBL AAL55642.1.
[9]	"Comparative genetic analysis of simian/human immunodeficiency viruses (SHIVs) with pathogenic property." Sakai K., Shinohara K., Takahashi E., Ami Y., Sasaki Y., Suzaki Y., Nakasone T., Honda M. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SHIV-C2/1 EMBL AAL55642.1.
[10]	Reimann K.A., Li J.T., Voss G., Lekutis C., Tenner-Racz K., Racz P., Lin W., Montefiori D.C., Lee-Parritz D.E., Lu Y., Collman R.G., Sodroski J., Letvin N.L. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SHIV-4 EMBL AAB99972.1 and SHIV-89.6 EMBL AAB99962.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF038398 Other DNA. Translation: AAB99962.1. AF038399 Other DNA. Translation: AAB99972.1. U89134 Other DNA. Translation: AAC57423.1. AF041850 Other DNA. Translation: AAD12138.1. AF217181 Other RNA. Translation: AAL55642.1. AY751799 Other RNA. Translation: AAV28698.1. EF672090 Other RNA. Translation: ABS11165.1.
RefSeq	NP_046126.1. NC_001870.1.
3D structure databases
HSSP	HSSP built from PDB template 1DSK based on UniProtKB P12520.
ProteinModelPortal	Q88017.
SMR	Q88017. Positions 51-83.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1446396.
Family and domain databases
InterPro	IPR000012. RetroV_VpR/X. [Graphical view]
Pfam	PF00522. VPR. 1 hit. [Graphical view]
PRINTS	PR00444. HIVVPRVPX.
ProtoNet	Search...

Entry information

Entry name

Q88017_9PLVG

Accession

Primary (citable) accession number: Q88017
Secondary accession number(s): O12622, O12903

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Family and domain databases

Entry information