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Q87Z79

- HGD_PSESM

UniProt

Q87Z79 - HGD_PSESM

Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Pseudomonas syringae pv. tomato (strain DC3000)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (06 Jun 2003)
      Previous versions | rss
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    Functioni

    Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

    Cofactori

    Iron.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei289 – 2891Proton acceptorUniRule annotation
    Metal bindingi332 – 3321IronUniRule annotation
    Metal bindingi338 – 3381IronUniRule annotation
    Binding sitei347 – 3471homogentisateUniRule annotation
    Metal bindingi368 – 3681IronUniRule annotation
    Binding sitei368 – 3681homogentisateUniRule annotation

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
    2. tyrosine catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciPSYR223283:GJIX-3608-MONOMER.
    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
    Short name:
    HGDOUniRule annotation
    Alternative name(s):
    Homogentisate oxygenaseUniRule annotation
    Homogentisic acid oxidaseUniRule annotation
    HomogentisicaseUniRule annotation
    Gene namesi
    Name:hmgAUniRule annotation
    Ordered Locus Names:PSPTO_3551
    OrganismiPseudomonas syringae pv. tomato (strain DC3000)
    Taxonomic identifieri223283 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002515: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Homogentisate 1,2-dioxygenasePRO_0000220251Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer; dimer of trimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi223283.PSPTO_3551.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87Z79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3508.
    HOGENOMiHOG000139824.
    KOiK00451.
    OMAiRCFYNSD.
    OrthoDBiEOG6D5FZK.
    PhylomeDBiQ87Z79.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00334. Homogentis_dioxygen.
    InterProiIPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q87Z79-1 [UniParc]FASTAAdd to Basket

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    MAIHSSFEAL AYQSGFANQF SSEALPGALP MGQNSPQKHP LGLYAEQFSG    50
    TAFTVARNEA RRTWLYRIKP SAAHPRYQRM DRQITGREQG PINPNRLRWN 100
    AFDIPAEPVD FIDGLIALAS TSAADQAEGV SVYVYAANTS MQRAFFSADG 150
    EWLIVPQQGR LRIITEMGVL DIGPLEIAVL PRGLKFSVQL LDGSARGYLC 200
    ENHGGVLRLP ELGPIGSNGL ANPRDFLTPV AWFEERDEPV QLVQKFLGEL 250
    WTTQLQHSPF DVVGWHGNNV PYTYDLRRFN TIGTVSYDHP DPSIFTVLTS 300
    PGAVHGQANI DFVIFPPRWM VAENTFRPPW FHRNLMNEFM GLIDGAYDAK 350
    AEGFMPGGSS LHNCMSAHGP DNITAEKAIA ADLKPHKIEN TMAFMFETGK 400
    VLRPSLHALA CPQLQADYDA CWNGMARTFN KESS 434
    Length:434
    Mass (Da):48,141
    Last modified:June 6, 2003 - v1
    Checksum:i222B118DF97AAB9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016853 Genomic DNA. Translation: AAO57026.1.
    RefSeqiNP_793331.1. NC_004578.1.

    Genome annotation databases

    EnsemblBacteriaiAAO57026; AAO57026; PSPTO_3551.
    GeneIDi1185216.
    KEGGipst:PSPTO_3551.
    PATRICi19998537. VBIPseSyr93040_3640.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016853 Genomic DNA. Translation: AAO57026.1 .
    RefSeqi NP_793331.1. NC_004578.1.

    3D structure databases

    ProteinModelPortali Q87Z79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 223283.PSPTO_3551.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO57026 ; AAO57026 ; PSPTO_3551 .
    GeneIDi 1185216.
    KEGGi pst:PSPTO_3551.
    PATRICi 19998537. VBIPseSyr93040_3640.

    Phylogenomic databases

    eggNOGi COG3508.
    HOGENOMi HOG000139824.
    KOi K00451.
    OMAi RCFYNSD.
    OrthoDBi EOG6D5FZK.
    PhylomeDBi Q87Z79.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .
    BioCyci PSYR223283:GJIX-3608-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00334. Homogentis_dioxygen.
    InterProi IPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DC3000.

    Entry informationi

    Entry nameiHGD_PSESM
    AccessioniPrimary (citable) accession number: Q87Z79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2003
    Last sequence update: June 6, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3