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Q87Z79

- HGD_PSESM

UniProt

Q87Z79 - HGD_PSESM

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Protein
Homogentisate 1,2-dioxygenase
Gene
hmgA, PSPTO_3551
Organism
Pseudomonas syringae pv. tomato (strain DC3000)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate By similarity.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei289 – 2891Proton acceptor By similarity
Metal bindingi332 – 3321Iron By similarity
Metal bindingi338 – 3381Iron By similarity
Binding sitei347 – 3471homogentisate By similarity
Metal bindingi368 – 3681Iron By similarity
Binding sitei368 – 3681homogentisate By similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciPSYR223283:GJIX-3608-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Short name:
HGDO
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hmgA
Ordered Locus Names:PSPTO_3551
OrganismiPseudomonas syringae pv. tomato (strain DC3000)
Taxonomic identifieri223283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002515: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Homogentisate 1,2-dioxygenaseUniRule annotation
PRO_0000220251Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi223283.PSPTO_3551.

Structurei

3D structure databases

ProteinModelPortaliQ87Z79.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiRCFYNSD.
OrthoDBiEOG6D5FZK.
PhylomeDBiQ87Z79.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q87Z79-1 [UniParc]FASTAAdd to Basket

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MAIHSSFEAL AYQSGFANQF SSEALPGALP MGQNSPQKHP LGLYAEQFSG    50
TAFTVARNEA RRTWLYRIKP SAAHPRYQRM DRQITGREQG PINPNRLRWN 100
AFDIPAEPVD FIDGLIALAS TSAADQAEGV SVYVYAANTS MQRAFFSADG 150
EWLIVPQQGR LRIITEMGVL DIGPLEIAVL PRGLKFSVQL LDGSARGYLC 200
ENHGGVLRLP ELGPIGSNGL ANPRDFLTPV AWFEERDEPV QLVQKFLGEL 250
WTTQLQHSPF DVVGWHGNNV PYTYDLRRFN TIGTVSYDHP DPSIFTVLTS 300
PGAVHGQANI DFVIFPPRWM VAENTFRPPW FHRNLMNEFM GLIDGAYDAK 350
AEGFMPGGSS LHNCMSAHGP DNITAEKAIA ADLKPHKIEN TMAFMFETGK 400
VLRPSLHALA CPQLQADYDA CWNGMARTFN KESS 434
Length:434
Mass (Da):48,141
Last modified:June 6, 2003 - v1
Checksum:i222B118DF97AAB9C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016853 Genomic DNA. Translation: AAO57026.1.
RefSeqiNP_793331.1. NC_004578.1.

Genome annotation databases

EnsemblBacteriaiAAO57026; AAO57026; PSPTO_3551.
GeneIDi1185216.
KEGGipst:PSPTO_3551.
PATRICi19998537. VBIPseSyr93040_3640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016853 Genomic DNA. Translation: AAO57026.1 .
RefSeqi NP_793331.1. NC_004578.1.

3D structure databases

ProteinModelPortali Q87Z79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223283.PSPTO_3551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO57026 ; AAO57026 ; PSPTO_3551 .
GeneIDi 1185216.
KEGGi pst:PSPTO_3551.
PATRICi 19998537. VBIPseSyr93040_3640.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi RCFYNSD.
OrthoDBi EOG6D5FZK.
PhylomeDBi Q87Z79.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci PSYR223283:GJIX-3608-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DC3000.

Entry informationi

Entry nameiHGD_PSESM
AccessioniPrimary (citable) accession number: Q87Z79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: June 6, 2003
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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