Reviewed, UniProtKB/Swiss-Prot Q87Z79 (HGD_PSESM)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	PSPTO_3551

Organism

Pseudomonas syringae pv. tomato [Complete proteome] [HAMAP]

Taxonomic identifier

323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Homogentisate 1,2-dioxygenase HAMAP MF_00334		PRO_0000220251
Sites
	Metal binding	332	1	Iron By similarity
	Metal binding	338	1	Iron By similarity
	Metal binding	368	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q87Z79-1 [UniParc]. Last modified June 6, 2003. Version 1. Checksum: 222B118DF97AAB9C	FASTA	434	48,141
	10 20 30 40 50 60 MAIHSSFEAL AYQSGFANQF SSEALPGALP MGQNSPQKHP LGLYAEQFSG TAFTVARNEA 70 80 90 100 110 120 RRTWLYRIKP SAAHPRYQRM DRQITGREQG PINPNRLRWN AFDIPAEPVD FIDGLIALAS 130 140 150 160 170 180 TSAADQAEGV SVYVYAANTS MQRAFFSADG EWLIVPQQGR LRIITEMGVL DIGPLEIAVL 190 200 210 220 230 240 PRGLKFSVQL LDGSARGYLC ENHGGVLRLP ELGPIGSNGL ANPRDFLTPV AWFEERDEPV 250 260 270 280 290 300 QLVQKFLGEL WTTQLQHSPF DVVGWHGNNV PYTYDLRRFN TIGTVSYDHP DPSIFTVLTS 310 320 330 340 350 360 PGAVHGQANI DFVIFPPRWM VAENTFRPPW FHRNLMNEFM GLIDGAYDAK AEGFMPGGSS 370 380 390 400 410 420 LHNCMSAHGP DNITAEKAIA ADLKPHKIEN TMAFMFETGK VLRPSLHALA CPQLQADYDA 430 CWNGMARTFN KESS

References

[1]

"The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000." Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T., Gwinn M.L., Dodson R.J., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Daugherty S.C., Brinkac L.M., Beanan M.J., Haft D.H., Nelson W.C., Davidsen T.M., Zafar N. , Zhou L., Liu J., Yuan Q., Khouri H.M., Fedorova N.B., Tran B., Russell D., Berry K.J., Utterback T.R., Van Aken S.E., Feldblyum T.V., D'Ascenzo M., Deng W.-L., Ramos A.R., Alfano J.R., Cartinhour S., Chatterjee A.K., Delaney T.P., Lazarowitz S.G., Martin G.B., Schneider D.J., Tang X., Bender C.L., White O., Fraser C.M., Collmer A. Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003) [PubMed: 12928499] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DC3000.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016853 Genomic DNA. Translation: AAO57026.1.
RefSeq	NP_793331.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1185216.
GenomeReviews	Gene locus PSPTO_3551 in contig AE016853_GR.
KEGG	pst:PSPTO_3551.
NMPDR	fig|223283.1.peg.3469.
TIGR	PSPTO_3551.
Phylogenomic databases
HOGENOM	Q87Z79.
OMA	Q87Z79. HRNCMSE.
Enzyme and pathway databases
BioCyc	PSYR223283:PSPTO_3551-MON.
BRENDA	1.13.11.5. 289554.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_PSESM

Accession

Primary (citable) accession number: Q87Z79

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2003
Last sequence update:	June 6, 2003
Last modified:	May 5, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)