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Reviewed, UniProtKB/Swiss-Prot Q87XJ6 (DDLA_PSESM)

Last modified November 25, 2008. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    D-alanine--D-alanine ligase A
    EC=6.3.2.4
Alternative name(s):
    D-alanylalanine synthetase A
    D-Ala-D-Ala ligase A
Gene names
Name: ddlA
Ordered Locus Names: PSPTO_4182
OrganismPseudomonas syringae pv. tomato [Complete proteome] [HAMAP]
Taxonomic identifier323 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Cell wall formation By similarity.

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

CytoplasmBy similarity.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363D-alanine--D-alanine ligase A
PRO_0000177859

Regions

Domain144 – 345202ATP-grasp
Nucleotide binding172 – 22756ATP By similarity

Sites

Metal binding2991Magnesium or manganese 1 By similarity
Metal binding3121Magnesium or manganese 1 By similarity
Metal binding3121Magnesium or manganese 2 By similarity
Metal binding3141Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87XJ6-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 8E9772ACDAB380FF

FASTA36338,948
        10         20         30         40         50         60 
MKKSVAIVFG GQSSEHEVSL QSARNVINAI DRESYALTLI GVDKLGRWLR FDEADYLLNA 

        70         80         90        100        110        120 
NDPARIKLSG SGKQLSLLPG SVGGQFVEVE SGKPLAAIDV VFPLIHGAFG EDGALQGLLR 

       130        140        150        160        170        180 
MLAVPFVGAD VLASAACMDK DVTKRLLRDA GIAVAPFMVL NRGESLSFAQ AAAQLSLPMF 

       190        200        210        220        230        240 
VKPANQGSSV GVSKVSDEAG FAAALALGFE FDHKLLIEQG IVGREVECAV LGNDEAQVSV 

       250        260        270        280        290        300 
CGEVVANDEF YAYDTKYLNG DQARIAIPAE LPADLSDQVR DVALQAYKVL GCAGLSRVDF 

       310        320        330        340        350        360 
FVTEAREIII NEVNTLPGFT SISMYPKLWQ ATGLSYAELI HRLIVLALER ADEARLLKRD 


IFA 

« Hide

Cross-references

Sequence databases

AE016853 Genomic DNA. Translation: AAO57638.1.
RefSeqNP_793943.1.

3D structure databases

HSSPHSSP built from PDB template 1E4E based on UniProtKB P25051.
ModBaseSearch...

Genome annotation databases

GeneID1185862.
GenomeReviewsGene locus PSPTO_4182 in contig AE016853_GR.
KEGGpst:PSPTO_4182.
NMPDRfig|223283.1.peg.4081.
TIGRPSPTO_4182.

Phylogenomic databases

HOGENOMQ87XJ6.

Enzyme and pathway databases

BioCycPSYR223283:PSPTO_4182-MON.

Family and domain databases

HAMAPMF_00047.
[Tree]
InterProIPR011761. ATP-grasp.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR013817. Pre-ATP_grasp.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDLA_PSESM
AccessionPrimary (citable) accession number: Q87XJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: November 25, 2008
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents