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Q87XJ6 (DDLA_PSESM) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase A

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase A
D-alanylalanine synthetase A
Gene names
Name:ddlA
Ordered Locus Names:PSPTO_4182
OrganismPseudomonas syringae pv. tomato (strain DC3000) [Complete proteome] [HAMAP]
Taxonomic identifier223283 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363D-alanine--D-alanine ligase A HAMAP-Rule MF_00047
PRO_0000177859

Regions

Domain144 – 345202ATP-grasp
Nucleotide binding172 – 22756ATP By similarity

Sites

Metal binding2991Magnesium or manganese 1 By similarity
Metal binding3121Magnesium or manganese 1 By similarity
Metal binding3121Magnesium or manganese 2 By similarity
Metal binding3141Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87XJ6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 8E9772ACDAB380FF

FASTA36338,948
        10         20         30         40         50         60 
MKKSVAIVFG GQSSEHEVSL QSARNVINAI DRESYALTLI GVDKLGRWLR FDEADYLLNA 

        70         80         90        100        110        120 
NDPARIKLSG SGKQLSLLPG SVGGQFVEVE SGKPLAAIDV VFPLIHGAFG EDGALQGLLR 

       130        140        150        160        170        180 
MLAVPFVGAD VLASAACMDK DVTKRLLRDA GIAVAPFMVL NRGESLSFAQ AAAQLSLPMF 

       190        200        210        220        230        240 
VKPANQGSSV GVSKVSDEAG FAAALALGFE FDHKLLIEQG IVGREVECAV LGNDEAQVSV 

       250        260        270        280        290        300 
CGEVVANDEF YAYDTKYLNG DQARIAIPAE LPADLSDQVR DVALQAYKVL GCAGLSRVDF 

       310        320        330        340        350        360 
FVTEAREIII NEVNTLPGFT SISMYPKLWQ ATGLSYAELI HRLIVLALER ADEARLLKRD 


IFA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016853 Genomic DNA. Translation: AAO57638.1.
RefSeqNP_793943.1. NC_004578.1.

3D structure databases

ProteinModelPortalQ87XJ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING223283.PSPTO_4182.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO57638; AAO57638; PSPTO_4182.
GeneID1185862.
KEGGpst:PSPTO_4182.
PATRIC19999861. VBIPseSyr93040_4292.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAQIDVIFP.
OrthoDBEOG64BQ73.
PhylomeDBQ87XJ6.

Enzyme and pathway databases

BioCycPSYR223283:GJIX-4246-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDLA_PSESM
AccessionPrimary (citable) accession number: Q87XJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways