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Q87WW4 (SYW_PSESM) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:PSPTO_4429
OrganismPseudomonas syringae pv. tomato (strain DC3000) [Complete proteome] [HAMAP]
Taxonomic identifier223283 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136664

Regions

Motif11 – 199"HIGH" region HAMAP-Rule MF_00140
Motif204 – 2085"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2071ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87WW4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7697DB7C99120F85

FASTA44949,635
        10         20         30         40         50         60 
MTTRILTGIT TTGTPHLGNY AGAIRPAIVA SRQSDVDSFY FLADYHALIK CDDPLRIQRS 

        70         80         90        100        110        120 
RLEIAATWLA AGLDVDRVTF YRQSDIPEIP ELTWLLTCVA AKGLLNRAHA YKASVDKNVE 

       130        140        150        160        170        180 
SCEDPDAGIT MGLYSYPVLM AADILMFNAH QVPVGRDQIQ HVEMARDIGQ RFNHLFGKGR 

       190        200        210        220        230        240 
EFFVMPEALI EESVATLPGL DGRKMSKSYD NTIPLFSSAK DMKSAISRIV TDSLAPGEAK 

       250        260        270        280        290        300 
DPDNSHLFTL YQAFSTPEQC AQFRSELLQG LGWGEAKTRM FTLLDEQLGE AREQYLSLIE 

       310        320        330        340        350        360 
RPADLEDILL AGAQKARRVA TPFLEELREA VGLRSFRTAV QNADTGKKKT TKGARFVSFR 

       370        380        390        400        410        420 
EDDGSFRFRL LAADGEQLLL SRTFADGKAA GIVSKQLQQG GELDLRSEAD RFTLWLNGEC 

       430        440 
VADSPVFADA TARDNAVETL KLALAPQQD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016853 Genomic DNA. Translation: AAO57878.1.
RefSeqNP_794183.1. NC_004578.1.

3D structure databases

ProteinModelPortalQ87WW4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING223283.PSPTO_4429.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO57878; AAO57878; PSPTO_4429.
GeneID1186110.
KEGGpst:PSPTO_4429.
PATRIC20000368. VBIPseSyr93040_4544.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059939.
KOK01867.
OMALELYWIL.
OrthoDBEOG686NJQ.
PhylomeDBQ87WW4.

Enzyme and pathway databases

BioCycPSYR223283:GJIX-4495-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYW_PSESM
AccessionPrimary (citable) accession number: Q87WW4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries