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Q87WV5

- HISX_PSESM

UniProt

Q87WV5 - HISX_PSESM

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Pseudomonas syringae pv. tomato (strain DC3000)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361NADUniRule annotation
Binding sitei197 – 1971NADUniRule annotation
Binding sitei220 – 2201NADUniRule annotation
Binding sitei243 – 2431SubstrateUniRule annotation
Metal bindingi265 – 2651ZincUniRule annotation
Binding sitei265 – 2651SubstrateUniRule annotation
Metal bindingi268 – 2681ZincUniRule annotation
Binding sitei268 – 2681SubstrateUniRule annotation
Active sitei333 – 3331Proton acceptorUniRule annotation
Active sitei334 – 3341Proton acceptorUniRule annotation
Binding sitei334 – 3341SubstrateUniRule annotation
Metal bindingi367 – 3671ZincUniRule annotation
Binding sitei367 – 3671SubstrateUniRule annotation
Binding sitei421 – 4211SubstrateUniRule annotation
Metal bindingi426 – 4261ZincUniRule annotation
Binding sitei426 – 4261SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPSYR223283:GJIX-4504-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PSPTO_4438
OrganismiPseudomonas syringae pv. tomato (strain DC3000)
Taxonomic identifieri223283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002515: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Histidinol dehydrogenasePRO_0000135824Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi223283.PSPTO_4438.

Structurei

3D structure databases

ProteinModelPortaliQ87WV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ87WV5.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87WV5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTPTAIRRL DAADPDFARH LDHLLSWESV SDDSVNQRVL DIIKAVRERG
60 70 80 90 100
DAALVELTQK FDGLQVASMA ELILPRERLE LALTRITPVQ RQALEKAAER
110 120 130 140 150
VRSYHEKQKQ DSWSYTEADG TVLGQKVTPL DRAGLYVPGG KASYPSSVLM
160 170 180 190 200
NAIPAKVAGV TEVVMVVPTP RGEINELVLA AACIAGVDRV FTIGGAQAVA
210 220 230 240 250
ALAYGTESVP KVDKVVGPGN IYVATAKRHV FGQVGIDMIA GPSEILVVCD
260 270 280 290 300
GQTDPDWIAM DLFSQAEHDE DAQAILVSPD AEFLDKVAAS ITRLLPTMAR
310 320 330 340 350
AAIVETSING RGALIKVADM AQAIEVANRI APEHLELSVA DPEAWLPHIR
360 370 380 390 400
HAGAIFMGRH TSEALGDYCA GPNHVLPTSG TARFSSPLGV YDFQKRSSII
410 420 430 440
YCSPEGASEL GKTASVLARG ESLSGHARSA EYRITDLDWK TGNLEEGK
Length:448
Mass (Da):48,119
Last modified:June 6, 2003 - v1
Checksum:iB678B0C911692521
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA. Translation: AAO57887.1.
RefSeqiNP_794192.1. NC_004578.1.

Genome annotation databases

EnsemblBacteriaiAAO57887; AAO57887; PSPTO_4438.
GeneIDi1186119.
KEGGipst:PSPTO_4438.
PATRICi20000388. VBIPseSyr93040_4554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016853 Genomic DNA. Translation: AAO57887.1 .
RefSeqi NP_794192.1. NC_004578.1.

3D structure databases

ProteinModelPortali Q87WV5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223283.PSPTO_4438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO57887 ; AAO57887 ; PSPTO_4438 .
GeneIDi 1186119.
KEGGi pst:PSPTO_4438.
PATRICi 20000388. VBIPseSyr93040_4554.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.
PhylomeDBi Q87WV5.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PSYR223283:GJIX-4504-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DC3000.

Entry informationi

Entry nameiHISX_PSESM
AccessioniPrimary (citable) accession number: Q87WV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: June 6, 2003
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3