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Q87WV5 (HISX_PSESM) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:PSPTO_4438
OrganismPseudomonas syringae pv. tomato (strain DC3000) [Complete proteome] [HAMAP]
Taxonomic identifier223283 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135824

Sites

Active site3331Proton acceptor By similarity
Active site3341Proton acceptor By similarity
Metal binding2651Zinc By similarity
Metal binding2681Zinc By similarity
Metal binding3671Zinc By similarity
Metal binding4261Zinc By similarity
Binding site1361NAD By similarity
Binding site1971NAD By similarity
Binding site2201NAD By similarity
Binding site2431Substrate By similarity
Binding site2651Substrate By similarity
Binding site2681Substrate By similarity
Binding site3341Substrate By similarity
Binding site3671Substrate By similarity
Binding site4211Substrate By similarity
Binding site4261Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87WV5 [UniParc].

Last modified June 6, 2003. Version 1.
Checksum: B678B0C911692521

FASTA44848,119
        10         20         30         40         50         60 
MTTPTAIRRL DAADPDFARH LDHLLSWESV SDDSVNQRVL DIIKAVRERG DAALVELTQK 

        70         80         90        100        110        120 
FDGLQVASMA ELILPRERLE LALTRITPVQ RQALEKAAER VRSYHEKQKQ DSWSYTEADG 

       130        140        150        160        170        180 
TVLGQKVTPL DRAGLYVPGG KASYPSSVLM NAIPAKVAGV TEVVMVVPTP RGEINELVLA 

       190        200        210        220        230        240 
AACIAGVDRV FTIGGAQAVA ALAYGTESVP KVDKVVGPGN IYVATAKRHV FGQVGIDMIA 

       250        260        270        280        290        300 
GPSEILVVCD GQTDPDWIAM DLFSQAEHDE DAQAILVSPD AEFLDKVAAS ITRLLPTMAR 

       310        320        330        340        350        360 
AAIVETSING RGALIKVADM AQAIEVANRI APEHLELSVA DPEAWLPHIR HAGAIFMGRH 

       370        380        390        400        410        420 
TSEALGDYCA GPNHVLPTSG TARFSSPLGV YDFQKRSSII YCSPEGASEL GKTASVLARG 

       430        440 
ESLSGHARSA EYRITDLDWK TGNLEEGK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016853 Genomic DNA. Translation: AAO57887.1.
RefSeqNP_794192.1. NC_004578.1.

3D structure databases

ProteinModelPortalQ87WV5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING223283.PSPTO_4438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO57887; AAO57887; PSPTO_4438.
GeneID1186119.
KEGGpst:PSPTO_4438.
PATRIC20000388. VBIPseSyr93040_4554.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAYAAKLCG.
OrthoDBEOG6CVVCR.
PhylomeDBQ87WV5.

Enzyme and pathway databases

BioCycPSYR223283:GJIX-4504-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_PSESM
AccessionPrimary (citable) accession number: Q87WV5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: June 6, 2003
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways