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Q87VR9 (PUR9_PSESM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:PSPTO_4866
OrganismPseudomonas syringae pv. tomato (strain DC3000) [Complete proteome] [HAMAP]
Taxonomic identifier223283 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length534 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 534534Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192114

Sequences

Sequence LengthMass (Da)Tools
Q87VR9 [UniParc].

Last modified June 20, 2003. Version 1.
Checksum: 002B14FE9EF285E6

FASTA53457,463
        10         20         30         40         50         60 
MTDQTTRLPI RRALISVSDK TGILEFAREL EALGVEILST GGTFKLLQDN GVAAVEVADY 

        70         80         90        100        110        120 
TGFAEMMDGR VKTLHPKIHG GILGRRGIDD AIMNEHGIKP IDLVAVNLYP FEATVSKPGC 

       130        140        150        160        170        180 
DLPTAIENID IGGPTMVRSA AKNHKDVAIV VNAGDYGQVL ESLKAGGLTY AQRFDLMLKA 

       190        200        210        220        230        240 
FEHTAAYDGM IANYLGGVDQ TADTLSTEGR SQFPRTFNTQ FVKAQEMRYG ENPHQSAAFY 

       250        260        270        280        290        300 
VEAKPAEVGI ATATQLQGKE LSFNNVADTD AALECVKSFV KPACVIVKHA NPCGVAVCPD 

       310        320        330        340        350        360 
DEGGIRQAYE LAYATDSESA FGGIIAFNRE LDAATAKAIV ERQFVEVIIA PSVSAEARSI 

       370        380        390        400        410        420 
IASKANVRLL TSGQWSERLP AWDYKRVNGG LLVQSRDIGM ITEADLKVVT QRAPTEHEMH 

       430        440        450        460        470        480 
DLIFAWKVAK YVKSNAIVYA RNRQTIGVGA GQMSRVNSAR IAAIKAEHAG LQVQGAVMAS 

       490        500        510        520        530 
DAFFPFRDGI DNAAKVGISA VIQPGGSMRD NEVIAAADEA GIAMVFTGMR HFRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016853 Genomic DNA. Translation: AAO58295.1.
RefSeqNP_794600.1. NC_004578.1.

3D structure databases

ProteinModelPortalQ87VR9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING223283.PSPTO_4866.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO58295; AAO58295; PSPTO_4866.
GeneID1186549.
KEGGpst:PSPTO_4866.
PATRIC20001240. VBIPseSyr93040_4978.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycPSYR223283:GJIX-4932-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_PSESM
AccessionPrimary (citable) accession number: Q87VR9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways