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Protein

3-ketoacyl-CoA thiolase

Gene

fadA

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Acyl-thioester intermediateUniRule annotation1
Active sitei347Proton acceptorUniRule annotation1
Active sitei377Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
Acetyl-CoA acyltransferaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadAUniRule annotation
Ordered Locus Names:VP0029
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002063971 – 3913-ketoacyl-CoA thiolaseAdd BLAST391

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).UniRule annotation

Protein-protein interaction databases

STRINGi223926.VP0029.

Structurei

3D structure databases

ProteinModelPortaliQ87TP0.
SMRiQ87TP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHU. Bacteria.
COG0183. LUCA.
HOGENOMiHOG000012239.
KOiK00632.
OMAiCGGTESM.

Family and domain databases

CDDicd00751. thiolase. 1 hit.
Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01620. FadA. 1 hit.
InterProiView protein in InterPro
IPR012805. FadA.
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
PfamiView protein in Pfam
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
TIGR02445. fadA. 1 hit.
PROSITEiView protein in PROSITE
PS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q87TP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNQTRNVVV VDCLRTPMGR SKGGAFRHTR AEDLSAHLMK GILARNPQVN
60 70 80 90 100
PSEIEDIYWG CVQQTLEQGF NIARNAALLA GLPIEIGAVT VNRLCGSSMQ
110 120 130 140 150
ALHDGTRAIM TGDAEICLIG GVEHMGHVPM NHGVDFHPGM SKNVAKAAGM
160 170 180 190 200
MGLTAEMLGK LHGISREQQD EFAARSHARA HAATLEGRFK NEILPTEGHA
210 220 230 240 250
ADGTLFQLDY DEVIRPETTV EGLSQLRPVF DPANGTVTAG TSSALSDGAS
260 270 280 290 300
AMLIMSEEKA NELGLKIRAR IKGMAIAGCD PSIMGYGPVP ATQKALKRAG
310 320 330 340 350
LAIEDMDVVE LNEAFAAQSL PCAKDLGLLE VMDEKVNLNG GAIALGHPLG
360 370 380 390
CSGARISTTL INLMEAKDAK YGLATMCIGL GQGIATVFER P
Length:391
Mass (Da):41,406
Last modified:June 1, 2003 - v1
Checksum:i7684DD4DC775E2E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC58292.1.
RefSeqiNP_796408.1. NC_004603.1.
WP_005458696.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC58292; BAC58292; BAC58292.
GeneIDi1187485.
KEGGivpa:VP0029.
PATRICifig|223926.6.peg.29.

Similar proteinsi

Entry informationi

Entry nameiFADA_VIBPA
AccessioniPrimary (citable) accession number: Q87TP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families