Reviewed, UniProtKB/Swiss-Prot Q87TF3 (ADD1_VIBPA)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase 1
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase 1

Gene names

Name:	add1
Ordered Locus Names:	VP0116

Organism

Vibrio parahaemolyticus [Complete proteome] [HAMAP]

Taxonomic identifier

670 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Adenosine deaminase 1 HAMAP MF_00540		PRO_0000194398
Sites
	Active site	197	1	Potential
	Active site	245	1	Potential
	Active site	278	1	Potential
	Active site	279	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q87TF3-1 [UniParc]. Last modified May 30, 2003. Version 1. Checksum: 26D0BF9E198514BD	FASTA	334	36,436
	10 20 30 40 50 60 MITKNLPLTD LHRHLDGNIR TKTILELGQK FGIALPAYDI ESLTPHVQIV EAEPSLVAFL 70 80 90 100 110 120 SKLDWGVAVL GDLDACRRVA YENVEDALNA QIDYAELRFS PYYMAMKHKL PVAGVVEAVV 130 140 150 160 170 180 DGVQAGMRDF GIKANLIGIM SRTFGTDACQ QELDAILSQK DHIVAVDLAG DELGQPGERF 190 200 210 220 230 240 VSHFKQVRDA GLNVTVHAGE AAGAESMWQA IQELGATRIG HGVKAIHDPK LMDYLAENRI 250 260 270 280 290 300 GIESCLTSNF QTSTVDSLAN HPLKQFLDHG VLACLNTDDP AVEGIELPYE YEVAAPAAGL 310 320 330 SQEQIRQAQI NGLELAFISD AEKAELKEKV KDRV

References

[1]

"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae." Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T. Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RIMD 2210633 / Serotype O3:K6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000031 Genomic DNA. Translation: BAC58379.1.
RefSeq	NP_796495.1.
3D structure databases
SMR	Q87TF3. Positions 4-332.
ModBase	Search...
Genome annotation databases
GeneID	1187583.
GenomeReviews	Gene locus VP0116 in contig BA000031_GR.
KEGG	vpa:VP0116.
NMPDR	fig|223926.1.peg.116.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	FLKKLDW.
Enzyme and pathway databases
BioCyc	VPAR223926:VP0116-MONOMER.
BRENDA	3.5.4.4. 3063.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD1_VIBPA

Accession

Primary (citable) accession number: Q87TF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2003
Last sequence update:	May 30, 2003
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)