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Q87TF3 (ADD_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:add
Synonyms:add1
Ordered Locus Names:VP0116
OrganismVibrio parahaemolyticus [Complete proteome] [HAMAP]
Taxonomic identifier670 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenosine + H2O = inosine + NH3. HAMAP MF_00540

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenosine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Adenosine deaminase HAMAP MF_00540
PRO_0000194398

Sites

Active site2001Proton donor By similarity
Metal binding121Zinc; catalytic By similarity
Metal binding141Zinc; catalytic By similarity
Metal binding1971Zinc; catalytic By similarity
Metal binding2781Zinc; catalytic By similarity
Binding site141Substrate By similarity
Binding site161Substrate By similarity
Binding site1701Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site2791Substrate By similarity
Site2211Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87TF3 [UniParc].

Last modified May 30, 2003. Version 1.
Checksum: 26D0BF9E198514BD

FASTA33436,436
        10         20         30         40         50         60 
MITKNLPLTD LHRHLDGNIR TKTILELGQK FGIALPAYDI ESLTPHVQIV EAEPSLVAFL 

        70         80         90        100        110        120 
SKLDWGVAVL GDLDACRRVA YENVEDALNA QIDYAELRFS PYYMAMKHKL PVAGVVEAVV 

       130        140        150        160        170        180 
DGVQAGMRDF GIKANLIGIM SRTFGTDACQ QELDAILSQK DHIVAVDLAG DELGQPGERF 

       190        200        210        220        230        240 
VSHFKQVRDA GLNVTVHAGE AAGAESMWQA IQELGATRIG HGVKAIHDPK LMDYLAENRI 

       250        260        270        280        290        300 
GIESCLTSNF QTSTVDSLAN HPLKQFLDHG VLACLNTDDP AVEGIELPYE YEVAAPAAGL 

       310        320        330 
SQEQIRQAQI NGLELAFISD AEKAELKEKV KDRV

« Hide

References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633 / Serotype O3:K6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000031 Genomic DNA. Translation: BAC58379.1.
RefSeqNP_796495.1. NC_004603.1.

3D structure databases

ProteinModelPortalQ87TF3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1187583.
GenomeReviewsGene locus VP0116 in contig BA000031_GR.
KEGGvpa:VP0116.
NMPDRfig|223926.1.peg.116.
PATRIC20138464. VBIVibPar50997_0107.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG630382.
OMAPYYMAMN.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycVPAR223926:VP0116-MONOMER.

Family and domain databases

HAMAPMF_00540. A_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADD_VIBPA
AccessionPrimary (citable) accession number: Q87TF3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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