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Protein

Adenylyl-sulfate kinase

Gene

cysC

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of activated sulfate.

Catalytic activityi

ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.UniRule annotation

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes sulfite from sulfate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase subunit 1 (cysN), Sulfate adenylyltransferase subunit 2 (cysD)
  2. Adenylyl-sulfate kinase (cysC)
  3. Phosphoadenosine phosphosulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei113Phosphoserine intermediateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVPAR223926:G1GTB-307-MONOMER
UniPathwayiUPA00140; UER00205

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl-sulfate kinaseUniRule annotation (EC:2.7.1.25UniRule annotation)
Alternative name(s):
APS kinaseUniRule annotation
ATP adenosine-5'-phosphosulfate 3'-phosphotransferaseUniRule annotation
Adenosine-5'-phosphosulfate kinaseUniRule annotation
Gene namesi
Name:cysCUniRule annotation
Ordered Locus Names:VP0296
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001059241 – 205Adenylyl-sulfate kinaseAdd BLAST205

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ87SX6

Interactioni

Protein-protein interaction databases

STRINGi223926.VP0296

Structurei

3D structure databases

ProteinModelPortaliQ87SX6
SMRiQ87SX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APS kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108I67 Bacteria
COG0529 LUCA
HOGENOMiHOG000228204
KOiK00860
OMAiVSPFRAD

Family and domain databases

CDDicd02027 APSK, 1 hit
HAMAPiMF_00065 Adenylyl_sulf_kinase, 1 hit
InterProiView protein in InterPro
IPR002891 APS_kinase
IPR027417 P-loop_NTPase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00455 apsK, 1 hit

Sequencei

Sequence statusi: Complete.

Q87SX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAETPVKDE NIVWHQHTVD KQFRAELKKQ KPAVLWFTGL SGAGKSTVAG
60 70 80 90 100
ALENRLAELG YHTYLLDGDN VRHGLCSDLG FSEQDRRENI RRIGELAKLM
110 120 130 140 150
ADAGLIVLSA FISPHRAERQ LVRDLLPEGE FIEVFVNASL EVCEGRDPKG
160 170 180 190 200
LYKKARAGEI PNFTGIDSEY QAPINPEIDL PAGEKSVEEL VELCLNELKQ

RRVIS
Length:205
Mass (Da):22,894
Last modified:May 23, 2003 - v1
Checksum:i03696F141F48199F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA Translation: BAC58559.1
RefSeqiNP_796675.1, NC_004603.1
WP_005454655.1, NC_004603.1

Genome annotation databases

EnsemblBacteriaiBAC58559; BAC58559; BAC58559
GeneIDi1187763
KEGGivpa:VP0296
PATRICifig|223926.6.peg.286

Similar proteinsi

Entry informationi

Entry nameiCYSC_VIBPA
AccessioniPrimary (citable) accession number: Q87SX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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