Reviewed, UniProtKB/Swiss-Prot Q87SQ3 (MTLD_VIBPA)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	VP0369

Organism

Vibrio parahaemolyticus [Complete proteome] [HAMAP]

Taxonomic identifier

670 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170730
Regions
	Nucleotide binding	4 – 15	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q87SQ3-1 [UniParc]. Last modified May 30, 2003. Version 1. Checksum: 9F5C141DF6769F0F	FASTA	382	41,978
	10 20 30 40 50 60 MKNAVHFGAG NIGRGFIGKL LADAEVEVTF ADVDVPLVDQ LSHKQEYKVK VVGTECKIDT 70 80 90 100 110 120 VTHVTAVNSA SEDVIDRIVK TDLVTTAVGP NVLDIIAKTI AKGIAKRFEA GNDAPLNIIA 130 140 150 160 170 180 CENMVRGTTH LKGEVYKHLD KSLHAKADEL VGFVDSAVDR IVPPAEAAND DPLEVTVESF 190 200 210 220 230 240 SEWIVDEQQF KGDIPNIAGM EKTNNLMAFV ERKLFTLNTG HCITAYLGCL KGHRTIREAI 250 260 270 280 290 300 EDPNIHAEVK QAMQESGEVL IRRYGFDHDM HNAYIEKILG RFANPYLVDE VDRVGRQPIR 310 320 330 340 350 360 KLGANDRLVK PLLGTIEYGT ENQTLLKGIA AALKYTNDTD PQAVELQTSL KEVGVTKTLA 370 380 KYTGLAEDSD EVAQIETLYN QL

References

[1]

"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae." Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T. Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RIMD 2210633 / Serotype O3:K6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000031 Genomic DNA. Translation: BAC58632.1.
RefSeq	NP_796748.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1187836.
GenomeReviews	Gene locus VP0369 in contig BA000031_GR.
KEGG	vpa:VP0369.
NMPDR	fig|223926.1.peg.369.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q87SQ3.
OMA	Q87SQ3. VDRIVPN.
Enzyme and pathway databases
BioCyc	VPAR223926:VP0369-MON.
BRENDA	1.1.1.17. 3063.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_VIBPA

Accession

Primary (citable) accession number: Q87SQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2003
Last sequence update:	May 30, 2003
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)