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Q87SL0 (UPPP_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:VP0413
OrganismVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) [Complete proteome] [HAMAP]
Taxonomic identifier223926 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151236

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane218 – 23821Helical; Potential
Transmembrane245 – 26521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q87SL0 [UniParc].

Last modified June 20, 2003. Version 1.
Checksum: 652CD8A803CA70BF

FASTA26729,277
        10         20         30         40         50         60 
MSYFEAFILA LIQGLTEFLP ISSSAHLILP SAIFGWADQG LAFDVAVHVG TLMAVVIYFR 

        70         80         90        100        110        120 
HEVITLFRAL FASIFKGDRS KEAKLAWMIV IATIPACVFG LLMKDVIEVY LRSAYVIATT 

       130        140        150        160        170        180 
TIVFGLLLWW VDKNAKLVAD EYQTGWKKAV FIGIAQALAM IPGTSRSGAT ITAALYLGFT 

       190        200        210        220        230        240 
REAAARFSFL MSIPIITLAG SYLGMKLVTS GEPVHVGFLL TGILTSFISA YICIHFFLKM 

       250        260 
ISRMGMTPFV IYRLILGVGL FAFLLSA 

« Hide

References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000031 Genomic DNA. Translation: BAC58676.1.
RefSeqNP_796792.1. NC_004603.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING223926.VP0413.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC58676; BAC58676; BAC58676.
GeneID1187881.
KEGGvpa:VP0413.
PATRIC20139036. VBIVibPar50997_0392.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMASDIMRIA.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycVPAR223926:GHK4-425-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_VIBPA
AccessionPrimary (citable) accession number: Q87SL0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families