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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:VP0413
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei39 – 59HelicalUniRule annotationAdd BLAST21
Transmembranei83 – 103HelicalUniRule annotationAdd BLAST21
Transmembranei111 – 131HelicalUniRule annotationAdd BLAST21
Transmembranei144 – 164HelicalUniRule annotationAdd BLAST21
Transmembranei189 – 209HelicalUniRule annotationAdd BLAST21
Transmembranei218 – 238HelicalUniRule annotationAdd BLAST21
Transmembranei245 – 265HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001512361 – 267Undecaprenyl-diphosphataseAdd BLAST267

Interactioni

Protein-protein interaction databases

STRINGi223926.VP0413.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218357.
KOiK06153.
OMAiAVMIYFR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q87SL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYFEAFILA LIQGLTEFLP ISSSAHLILP SAIFGWADQG LAFDVAVHVG
60 70 80 90 100
TLMAVVIYFR HEVITLFRAL FASIFKGDRS KEAKLAWMIV IATIPACVFG
110 120 130 140 150
LLMKDVIEVY LRSAYVIATT TIVFGLLLWW VDKNAKLVAD EYQTGWKKAV
160 170 180 190 200
FIGIAQALAM IPGTSRSGAT ITAALYLGFT REAAARFSFL MSIPIITLAG
210 220 230 240 250
SYLGMKLVTS GEPVHVGFLL TGILTSFISA YICIHFFLKM ISRMGMTPFV
260
IYRLILGVGL FAFLLSA
Length:267
Mass (Da):29,277
Last modified:June 20, 2003 - v1
Checksum:i652CD8A803CA70BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC58676.1.
RefSeqiNP_796792.1. NC_004603.1.
WP_005479178.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC58676; BAC58676; BAC58676.
GeneIDi1187881.
KEGGivpa:VP0413.
PATRICi20139036. VBIVibPar50997_0392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC58676.1.
RefSeqiNP_796792.1. NC_004603.1.
WP_005479178.1. NC_004603.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi223926.VP0413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC58676; BAC58676; BAC58676.
GeneIDi1187881.
KEGGivpa:VP0413.
PATRICi20139036. VBIVibPar50997_0392.

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218357.
KOiK06153.
OMAiAVMIYFR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUPPP_VIBPA
AccessioniPrimary (citable) accession number: Q87SL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.