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Q87SA0 (TYSY_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase
Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:thyA
Ordered Locus Names:VP0524
OrganismVibrio parahaemolyticus [Complete proteome] [HAMAP]
Taxonomic identifier670 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008

Subunit structure

Homodimer By similarity. HAMAP MF_00008

Subcellular location

Cytoplasm By similarity HAMAP MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Cellular componentCytoplasm
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthymidylate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Thymidylate synthase HAMAP MF_00008
PRO_0000141041

Sites

Active site1601 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87SA0 [UniParc].

Last modified May 23, 2003. Version 1.
Checksum: BFE25A7962F6EBC9

FASTA28332,780
        10         20         30         40         50         60 
MKQYLDLCQR IVDQGVWVEN ERTGKRCLTV INADLTYDVA NNQFPLVTTR KSFWKAAVAE 

        70         80         90        100        110        120 
LLGYIRGYDN AEDFRKLGTK TWDANANLND AWLNNPYRKG EDDMGRVYGV QGRAWAKPDG 

       130        140        150        160        170        180 
GHIDQLRKIV DDLTRGVDDR GEILNFYNPG EFHMGCLRPC MYSHHFSLLD DTLYLNSTQR 

       190        200        210        220        230        240 
SCDVPLGLNF NMVQVYVFLA IMAQITGKKP GQAFHKIVNA HIYEDQLELM RDVQLKREPL 

       250        260        270        280 
QAPTFHINPE IKSLEDLETW VTLDDFWVEG YEHHDPIRYP FSV

« Hide

References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633 / Serotype O3:K6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000031 Genomic DNA. Translation: BAC58787.1.
RefSeqNP_796903.1. NC_004603.1.

3D structure databases

ProteinModelPortalQ87SA0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1187992.
GenomeReviewsGene locus VP0524 in contig BA000031_GR.
KEGGvpa:VP0524.
NMPDRfig|223926.1.peg.524.
PATRIC20139250. VBIVibPar50997_0499.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG588098.
OMAPIKYPFS.
ProtClustDBPRK01827.

Enzyme and pathway databases

BioCycVPAR223926:VP0524-MONOMER.

Family and domain databases

HAMAPMF_00008. Thymidy_synth_bact.
[Tree]
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
Gene3DG3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
KOK00560.
PANTHERPTHR11549:SF2. Thymidylat_synth_C. 1 hit.
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. Thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_VIBPA
AccessionPrimary (citable) accession number: Q87SA0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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