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Q87S65

- RLUD_VIBPA

UniProt

Q87S65 - RLUD_VIBPA

Protein

Ribosomal large subunit pseudouridine synthase D

Gene

rluD

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA.By similarity

    Catalytic activityi

    23S rRNA uridine(1911)/uridine(1915)/uridine(1917) = 23S rRNA pseudouridine(1911)/pseudouridine(1915)/pseudouridine(1917).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei139 – 1391By similarity

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. pseudouridine synthesis Source: InterPro
    2. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciVPAR223926:GHK4-571-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal large subunit pseudouridine synthase D (EC:5.4.99.23)
    Alternative name(s):
    23S rRNA pseudouridine(1911/1915/1917) synthase
    rRNA pseudouridylate synthase D
    rRNA-uridine isomerase D
    Gene namesi
    Name:rluD
    Ordered Locus Names:VP0559
    OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
    Taxonomic identifieri223926 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002493: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Ribosomal large subunit pseudouridine synthase DPRO_0000162703Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi223926.VP0559.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87S65.
    SMRiQ87S65. Positions 2-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 9174S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pseudouridine synthase RluA family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0564.
    HOGENOMiHOG000275919.
    KOiK06180.
    OMAiRDIVHGG.
    OrthoDBiEOG6P070X.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR006225. PsdUridine_synth_RluC/D.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PfamiPF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 1 hit.
    TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
    PROSITEiPS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q87S65-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQQIVLTNT VKDSQLGQRL DQAIAELFAD FSRSRLKEWL LDGKVQVNGE    50
    VVTKPRTKVM GGEEITLQAE LEDEERWEAQ DIPLDIVYED DDIIVINKPR 100
    DFVVHPGAGT PDGTVLNALL HHYPDIAEVP RAGIVHRLDK DTTGLMVVAK 150
    TVPAQTRLVR ALQKRNITRE YEAIAIGRMT AGGKVDQPIG RHSTKRTLMA 200
    VAPLGKPAVT HYRVAEHFRE HTRIRLRLET GRTHQIRVHM SYLQHPLLGD 250
    TAYGGRARIP TGASQELTDM IRGFDRQALH AVMLRFEHPI TGEELEFHAP 300
    VPDDMVAMTE ALRKDTEEYG LPDEF 325
    Length:325
    Mass (Da):36,604
    Last modified:June 1, 2003 - v1
    Checksum:iD3359215265F1156
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000031 Genomic DNA. Translation: BAC58822.1.
    RefSeqiNP_796938.1. NC_004603.1.

    Genome annotation databases

    EnsemblBacteriaiBAC58822; BAC58822; BAC58822.
    GeneIDi1188027.
    KEGGivpa:VP0559.
    PATRICi20139314. VBIVibPar50997_0531.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000031 Genomic DNA. Translation: BAC58822.1 .
    RefSeqi NP_796938.1. NC_004603.1.

    3D structure databases

    ProteinModelPortali Q87S65.
    SMRi Q87S65. Positions 2-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 223926.VP0559.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC58822 ; BAC58822 ; BAC58822 .
    GeneIDi 1188027.
    KEGGi vpa:VP0559.
    PATRICi 20139314. VBIVibPar50997_0531.

    Phylogenomic databases

    eggNOGi COG0564.
    HOGENOMi HOG000275919.
    KOi K06180.
    OMAi RDIVHGG.
    OrthoDBi EOG6P070X.

    Enzyme and pathway databases

    BioCyci VPAR223926:GHK4-571-MONOMER.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR006225. PsdUridine_synth_RluC/D.
    IPR006224. PsdUridine_synth_RluC/D_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    Pfami PF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 1 hit.
    TIGRFAMsi TIGR00005. rluA_subfam. 1 hit.
    PROSITEi PS01129. PSI_RLU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
      Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
      Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RIMD 2210633.

    Entry informationi

    Entry nameiRLUD_VIBPA
    AccessioniPrimary (citable) accession number: Q87S65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3