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Protein

Polyphosphate kinase

Gene

ppk

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).UniRule annotation

Catalytic activityi

ATP + (phosphate)(n) = ADP + (phosphate)(n+1).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei433 – 4331Phosphohistidine intermediateUniRule annotation
Active sitei452 – 4521Phosphohistidine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-592-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyphosphate kinaseUniRule annotation (EC:2.7.4.1UniRule annotation)
Alternative name(s):
ATP-polyphosphate phosphotransferaseUniRule annotation
Polyphosphoric acid kinaseUniRule annotation
Gene namesi
Name:ppkUniRule annotation
Ordered Locus Names:VP0573
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Polyphosphate kinasePRO_0000128667Add
BLAST

Post-translational modificationi

An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to histidine residues through a N-P bond.UniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ87S51.

Interactioni

Protein-protein interaction databases

STRINGi223926.VP0573.

Structurei

3D structure databases

ProteinModelPortaliQ87S51.
SMRiQ87S51. Positions 4-684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini428 – 46235PLD phosphodiesteraseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyphosphate kinase family.UniRule annotation
Contains 1 PLD phosphodiesterase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUU. Bacteria.
COG0855. LUCA.
HOGENOMiHOG000248949.
KOiK00937.
OMAiLSSMIHA.

Family and domain databases

Gene3Di3.30.1840.10. 1 hit.
HAMAPiMF_00347. Polyphosphate_kinase. 1 hit.
InterProiIPR001736. PLipase_D/transphosphatidylase.
IPR003414. PP_kinase.
IPR024953. PP_kinase_middle.
IPR025200. PPK_C_dom.
IPR025198. PPK_N_dom.
[Graphical view]
PfamiPF02503. PP_kinase. 1 hit.
PF13090. PP_kinase_C. 1 hit.
PF13089. PP_kinase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015589. PP_kinase. 1 hit.
SUPFAMiSSF140356. SSF140356. 1 hit.
TIGRFAMsiTIGR03705. poly_P_kin. 1 hit.
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87S51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEKLYIEK ELSWLSFNER VLQEAADKTV PLIERIRFLG IFSNNLDEFY
60 70 80 90 100
KVRFADVKRR ILINQERGGS DNSKRLLSKM QAKALKLNEQ FDELYSELIR
110 120 130 140 150
EMARRRIFLV NEHQLDEAQE KWITKYFRKE VMPHITPLLM KDEIDVLQFL
160 170 180 190 200
KDEYAYIAVE LRKEDHSQYA LIEIPTDHLP RFVMVPEQKG KRRKTIILLD
210 220 230 240 250
NIIRYCLDEL FKGFFDYDEL AGYAMKMTRD AEYDLRNEIE YSLLEQMSAG
260 270 280 290 300
VNQRLTAMPV RFVYEREMPQ EMLDFLCSKL RISNYDNLIP GGRYHNFKDF
310 320 330 340 350
IAFPNVGREY LENKPMPPMK CADFEGYANS FEAIKAKDIL LYYPYHTFDH
360 370 380 390 400
IGELVRQASF DPKVLSIKIN IYRVAKDSRL MNSLIDAVHN GKNVTVVVEL
410 420 430 440 450
QARFDEEANI EWSKVLTEAG VHVIFGAPGL KIHSKLLMIS RREGDDIIRY
460 470 480 490 500
AHIGTGNFHE KTARIYTDFS LLTADQEITN EVRNVFGYIE NPYRPVKFNH
510 520 530 540 550
LMVSPRNSRT QIYRLIDNEI ANAKAGKKAG LTIKVNNLVD KGIVTRLYAA
560 570 580 590 600
SNAGVKINMI IRGMCALVPG IEGVSENIRI ISIVDRFLEH PRVVITHNDG
610 620 630 640 650
DPQVYISSAD WMTRNIDHRI EVAAPVRDPR LKQRIIDITN IHFTDTVKAR
660 670 680 690
LIDKEMSNSY VPRGNRKKVR SQVAIYDYLK NIEKQTRRQK SDVSDT
Length:696
Mass (Da):81,060
Last modified:May 30, 2003 - v1
Checksum:iE1FEF3B28337EEEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC58836.1.
RefSeqiNP_796952.1. NC_004603.1.
WP_005460183.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC58836; BAC58836; BAC58836.
GeneIDi1188048.
KEGGivpa:VP0573.
PATRICi20139354. VBIVibPar50997_0544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC58836.1.
RefSeqiNP_796952.1. NC_004603.1.
WP_005460183.1. NC_004603.1.

3D structure databases

ProteinModelPortaliQ87S51.
SMRiQ87S51. Positions 4-684.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi223926.VP0573.

Proteomic databases

PRIDEiQ87S51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC58836; BAC58836; BAC58836.
GeneIDi1188048.
KEGGivpa:VP0573.
PATRICi20139354. VBIVibPar50997_0544.

Phylogenomic databases

eggNOGiENOG4105CUU. Bacteria.
COG0855. LUCA.
HOGENOMiHOG000248949.
KOiK00937.
OMAiLSSMIHA.

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-592-MONOMER.

Family and domain databases

Gene3Di3.30.1840.10. 1 hit.
HAMAPiMF_00347. Polyphosphate_kinase. 1 hit.
InterProiIPR001736. PLipase_D/transphosphatidylase.
IPR003414. PP_kinase.
IPR024953. PP_kinase_middle.
IPR025200. PPK_C_dom.
IPR025198. PPK_N_dom.
[Graphical view]
PfamiPF02503. PP_kinase. 1 hit.
PF13090. PP_kinase_C. 1 hit.
PF13089. PP_kinase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015589. PP_kinase. 1 hit.
SUPFAMiSSF140356. SSF140356. 1 hit.
TIGRFAMsiTIGR03705. poly_P_kin. 1 hit.
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPK_VIBPA
AccessioniPrimary (citable) accession number: Q87S51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.