Reviewed, UniProtKB/Swiss-Prot Q87RR2 (GLYA1_VIBPA)

Names and origin

Protein names

Recommended name:
    Serine hydroxymethyltransferase 1
      Short name=Serine methylase 1
      Short name=SHMT 1
    EC=2.1.2.1

Gene names

Name:	glyA1
Ordered Locus Names:	VP0715

Organism

Vibrio parahaemolyticus [Complete proteome] [HAMAP]

Taxonomic identifier

670 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interconversion of serine and glycine. HAMAP MF_00051
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_00051
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051
Subunit structure	Homotetramer By similarity. HAMAP MF_00051
Subcellular location	Cytoplasm By similarity HAMAP MF_00051.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Serine hydroxymethyltransferase 1 HAMAP MF_00051		PRO_0000113692
Amino acid modifications
	Modified residue	229	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q87RR2-1 [UniParc]. Last modified May 23, 2003. Version 1. Checksum: D8B078D662D62BA2	FASTA	416	45,505
	10 20 30 40 50 60 MLKRDMNIAD YDAELFAAIQ EETLRQEEHI ELIASENYTS PRVMEAQGSQ LTNKYAEGYP 70 80 90 100 110 120 GKRYYGGCEY VDKAEQLAID RACKLFGCEY ANVQPHSGSQ ANSAVYMALL NPGDTVLGMS 130 140 150 160 170 180 LAHGGHLTHG SPVNFSGKHY NVIPYGIDEA GQINYDEMEQ LALEHKPKMI IGGFSAYSQI 190 200 210 220 230 240 VDWKRMREIA DKVDAYLFVD MAHVAGLIAA GEYPTPVPHA HVVTTTTHKT LAGPRGGLIL 250 260 270 280 290 300 SNAGEDMYKK LNSAVFPGGQ GGPLMHVIAG KAVAFKEAME PEFKAYQARV VKNAKAMVGQ 310 320 330 340 350 360 FQERGYKIVS NGTENHLFLV DLIDKDITGK DADAALGAAN ITVNKNSVPN DPRSPFVTSG 370 380 390 400 410 IRVGTPAITR RGFTEEDAKD LANWMCDVLD NIGNEEVIEA TKQKVLEICK RLPVYA

References

[1]

"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae." Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T. Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RIMD 2210633 / Serotype O3:K6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000031 Genomic DNA. Translation: BAC58978.1.
RefSeq	NP_797094.1.
3D structure databases
SMR	Q87RR2. Positions 1-416.
ModBase	Search...
Genome annotation databases
GeneID	1188190.
GenomeReviews	Gene locus VP0715 in contig BA000031_GR.
KEGG	vpa:VP0715.
NMPDR	fig|223926.1.peg.715.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG301263.
OMA	ICAKLPV.
Enzyme and pathway databases
BioCyc	VPAR223926:VP0715-MONOMER.
BRENDA	2.1.2.1. 3063.
Family and domain databases
HAMAP	MF_00051_B. SHMT_B. [Tree]
InterPro	IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLYA1_VIBPA

Accession

Primary (citable) accession number: Q87RR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
Last sequence update:	May 23, 2003
Last modified:	January 19, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)