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Q87RQ0

- SYL_VIBPA

UniProt

Q87RQ0 - SYL_VIBPA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (23 May 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei620 – 6201ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVPAR223926:GHK4-746-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:VP0727
    OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
    Taxonomic identifieri223926 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002493: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 857857Leucine--tRNA ligasePRO_0000152114Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi223926.VP0727.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87RQ0.
    SMRiQ87RQ0. Positions 228-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi617 – 6215"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiYAANYIL.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q87RQ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEQYNPQDI EQKVQKHWDD NKTFVVSEDP NKEKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VVSRFQRLQG KNVMQPIGWD AFGLPAENAA VKNNTAPAPW 100
    TYENIEYMKN QLKLLGFGYD WNREFATCTP EYYRWEQEFF TKLYEKGLVY 150
    KKTSSVNWCP NDQTVLANEQ VEDGCCWRCD TPVEQKEIPQ WFIKITEYAQ 200
    ELLDDLDKLE GWPEMVKTMQ RNWIGRSEGV ELKFEVKGQQ DLEVYTTRPD 250
    TLMGVTYVGI AAGHPLATLA AENNPELAAF IEECKNTKVA EAELATMEKK 300
    GMATGLTAIH PLNGREVPVY VANFVLMDYG TGAVMAVPAH DQRDFEFATK 350
    YGLDIIPVIK PADGSELDIS EAAYTEKGVL FDSGEFDGLE FQAAFDAIAA 400
    KLEAEGKGTK TVNFRLRDWG VSRQRYWGAP IPMVTTEDGE VHPVPADQLP 450
    VILPEDVVMD GVTSPIKADK EWAKTTFNGE PALRETDTFD TFMESSWYYA 500
    RYCSPQADDI LDPEKANYWL PVDQYIGGIE HACMHLLYSR FFHKLLRDAG 550
    YVTSDEPFKQ LLCQGMVLAD AFYFENEKGG KEWVAPTDVA VERDGKGRII 600
    SAKDNEGRDV THSGMIKMSK SKNNGIDPQE MVDKYGADTV RLFMMFASPA 650
    DMTLEWQESG VEGANRFLKR VWKLVKEHAE KGAAEAVDTA ALSGEQKALR 700
    RDVHKTIAKV TDDIARRQTF NTAIAAIMEL MNKLAKAPQE SAQDRAILDE 750
    ALKAVVTMLY PITPHISYEL WTALGESDID NAAWPTFDEK ALVEDEKTIV 800
    VQVNGKLRAK LTVAADATKE QVEELGLNDE NVTKFTDGLT IRKVIYVPGK 850
    LLNIVAN 857
    Length:857
    Mass (Da):96,654
    Last modified:May 23, 2003 - v1
    Checksum:iD84628AA1E5EE5EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000031 Genomic DNA. Translation: BAC58990.1.
    RefSeqiNP_797106.1. NC_004603.1.

    Genome annotation databases

    EnsemblBacteriaiBAC58990; BAC58990; BAC58990.
    GeneIDi1188202.
    KEGGivpa:VP0727.
    PATRICi20139658. VBIVibPar50997_0696.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000031 Genomic DNA. Translation: BAC58990.1 .
    RefSeqi NP_797106.1. NC_004603.1.

    3D structure databases

    ProteinModelPortali Q87RQ0.
    SMRi Q87RQ0. Positions 228-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 223926.VP0727.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC58990 ; BAC58990 ; BAC58990 .
    GeneIDi 1188202.
    KEGGi vpa:VP0727.
    PATRICi 20139658. VBIVibPar50997_0696.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi YAANYIL.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci VPAR223926:GHK4-746-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
      Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
      Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RIMD 2210633.

    Entry informationi

    Entry nameiSYL_VIBPA
    AccessioniPrimary (citable) accession number: Q87RQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 23, 2003
    Last sequence update: May 23, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3