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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi376 – 383ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:VP0982
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalUniRule annotationAdd BLAST21
Transmembranei63 – 80HelicalUniRule annotationAdd BLAST18
Transmembranei87 – 105HelicalUniRule annotationAdd BLAST19
Transmembranei142 – 162HelicalUniRule annotationAdd BLAST21
Transmembranei165 – 185HelicalUniRule annotationAdd BLAST21
Transmembranei249 – 269HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000926021 – 582Lipid A export ATP-binding/permease protein MsbAAdd BLAST582

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi223926.VP0982.

Structurei

3D structure databases

ProteinModelPortaliQ87R16.
SMRiQ87R16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 310ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini342 – 578ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q87R16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSINTDETTW QTFKRLWQFI RLYKSGLIVA VIALVINAIS DTYMISLLKP
60 70 80 90 100
LLDEGFGNAD SDFLRTLPLI IFVMMFIRGT SGFVSTYCLS WVSGNVVMLV
110 120 130 140 150
RRMVFNHFMH MPVSYFDKEK TGNLLSRITY DSEQVSAATS QALVSIVREG
160 170 180 190 200
ASIIGLLVLM FYNSWQLSLV LFAVAPVVAW GIGVVSKRFR KISKNMQTMM
210 220 230 240 250
GNVTASAEQM LKGHKVVLSY GGQDIERQRF DKVSNQMRQQ SMKLVTAQAA
260 270 280 290 300
ANPIIQMIAS FAIVAVLYLA SIDSIKEQLT PGTFTVVFSA MFGLMRPLKA
310 320 330 340 350
LTNVTSQFQR GMAASQTLFA LIDLEPEKNE GKYTVERAKG DVSVKDVSFT
360 370 380 390 400
YVGSEKPALE HVSFDIPRGK TVALVGRSGS GKSTIANLFN RFYDVDSGSI
410 420 430 440 450
TLDGRDIRDY ELKNLREQFA LVSQNVHLFN DTIANNIAYA TEDKYERSDI
460 470 480 490 500
EHAAKLAHAM EFINKMENGL DTMIGENGAS LSGGQRQRVA IARALLRDAP
510 520 530 540 550
VLILDEATSA LDTESERAIQ AALDELQKDK TVLVIAHRLS TIEKADEILV
560 570 580
VDDGAIIERG NHADLIAKNG AYAQLHRIQF GE
Length:582
Mass (Da):64,524
Last modified:June 1, 2003 - v1
Checksum:iD0AE3813E30E94A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC59245.1.
RefSeqiNP_797361.1. NC_004603.1.
WP_005456206.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC59245; BAC59245; BAC59245.
GeneIDi1188486.
KEGGivpa:VP0982.
PATRICifig|223926.6.peg.931.

Similar proteinsi

Entry informationi

Entry nameiMSBA_VIBPA
AccessioniPrimary (citable) accession number: Q87R16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families