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Protein

Protease HtpX

Gene

htpX

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi143 – 1431Zinc; catalyticUniRule annotation
Active sitei144 – 1441UniRule annotation
Metal bindingi147 – 1471Zinc; catalyticUniRule annotation
Metal bindingi221 – 2211Zinc; catalyticUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-1167-MONOMER.

Protein family/group databases

MEROPSiM48.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Protease HtpXUniRule annotation (EC:3.4.24.-UniRule annotation)
Alternative name(s):
Heat shock protein HtpXUniRule annotation
Gene namesi
Name:htpXUniRule annotation
Ordered Locus Names:VP1118
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalUniRule annotationAdd
BLAST
Transmembranei36 – 5621HelicalUniRule annotationAdd
BLAST
Transmembranei158 – 17821HelicalUniRule annotationAdd
BLAST
Transmembranei192 – 21221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Protease HtpXPRO_0000138904Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi223926.VP1118.

Structurei

Secondary structure

1
287
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni58 – 603Combined sources
Helixi77 – 9317Combined sources
Beta strandi99 – 1035Combined sources
Beta strandi106 – 1138Combined sources
Beta strandi121 – 1255Combined sources
Helixi126 – 1316Combined sources
Helixi134 – 14916Combined sources
Beta strandi153 – 1597Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CQBX-ray1.86A/B58-161[»]
ProteinModelPortaliQ87QN1.
SMRiQ87QN1. Positions 61-161.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ87QN1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M48B family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D0M. Bacteria.
COG0501. LUCA.
HOGENOMiHOG000227302.
KOiK03799.
OMAiVGKQKMI.
OrthoDBiEOG6F55J5.

Family and domain databases

HAMAPiMF_00188. Pept_M48_protease_HtpX.
InterProiIPR022919. Pept_M48_protease_HtpX.
IPR001915. Peptidase_M48.
[Graphical view]
PfamiPF01435. Peptidase_M48. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87QN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRIMLFLAT NLAVVLVLSV VLNIVYATTG MQPGSLSGLL VMAAVFGFGG
60 70 80 90 100
ALISLMMSKG MALRSVGGMV IESPRNETEH WLLETVGRQA QQAGIGMPTV
110 120 130 140 150
AIYDSADINA FATGAKRDDS LVAVSTGLLH NMTRDEAEAV LAHEVSHIAN
160 170 180 190 200
GDMVTMTLMQ GVVNTFVIFL SRFIANIVAS NDDEEGQGTN MMVYFGVSMV
210 220 230 240 250
LELVFGFLAS FITMWYSRHR EFHADAGAAR LVGKEKMIAA LERLKMSQES
260 270 280
KLDGTMMAFG INGKQSLTEL LMSHPPLDKR IAALRNQ
Length:287
Mass (Da):31,082
Last modified:May 30, 2003 - v1
Checksum:iD35DB10325654182
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC59381.1.
RefSeqiNP_797497.1. NC_004603.1.
WP_005459987.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC59381; BAC59381; BAC59381.
GeneIDi1188623.
KEGGivpa:VP1118.
PATRICi20140446. VBIVibPar50997_1060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC59381.1.
RefSeqiNP_797497.1. NC_004603.1.
WP_005459987.1. NC_004603.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CQBX-ray1.86A/B58-161[»]
ProteinModelPortaliQ87QN1.
SMRiQ87QN1. Positions 61-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi223926.VP1118.

Protein family/group databases

MEROPSiM48.002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC59381; BAC59381; BAC59381.
GeneIDi1188623.
KEGGivpa:VP1118.
PATRICi20140446. VBIVibPar50997_1060.

Phylogenomic databases

eggNOGiENOG4105D0M. Bacteria.
COG0501. LUCA.
HOGENOMiHOG000227302.
KOiK03799.
OMAiVGKQKMI.
OrthoDBiEOG6F55J5.

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-1167-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ87QN1.

Family and domain databases

HAMAPiMF_00188. Pept_M48_protease_HtpX.
InterProiIPR022919. Pept_M48_protease_HtpX.
IPR001915. Peptidase_M48.
[Graphical view]
PfamiPF01435. Peptidase_M48. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.
  2. "The crystal structure of heat shock protein Htpx domain from Vibrio parahaemolyticus RIMD 2210633."
    Midwest center for structural genomics (MCSG)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.86 ANGSTROMS) OF 58-161.

Entry informationi

Entry nameiHTPX_VIBPA
AccessioniPrimary (citable) accession number: Q87QN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: December 9, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.