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Q87QL2

- HIS1_VIBPA

UniProt

Q87QL2 - HIS1_VIBPA

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Protein
ATP phosphoribosyltransferase
Gene
hisG, VP1137
Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Enzyme regulationi

Feedback inhibited by histidine By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-1186-MONOMER.
UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase (EC:2.4.2.17)
Short name:
ATP-PRT
Short name:
ATP-PRTase
Gene namesi
Name:hisG
Ordered Locus Names:VP1137
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002493: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298ATP phosphoribosyltransferaseUniRule annotation
PRO_0000151870Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi223926.VP1137.

Structurei

3D structure databases

ProteinModelPortaliQ87QL2.
SMRiQ87QL2. Positions 5-298.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0040.
HOGENOMiHOG000223247.
KOiK00765.
OMAiSWRESRD.
OrthoDBiEOG66MQT3.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
HAMAPiMF_00079. HisG_Long.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87QL2-1 [UniParc]FASTAAdd to Basket

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MQTQRLRIAI QKKGRLSKES QALLKQCGVK FNVMGERLVV HSENMPIDLL    50
LVRDDDIPGL IMDGVVDLGF IGENELEEVR LDRKALGEPC EFVQLRRLDF 100
GGCRLSIAID KDEEYNGPQD LAGKRIATTY PQLLKAYMDE AGVPFSTCML 150
TGSVEVAPRA GLADAIADLV STGATLEANG LKEAEVIFRS KATLIQRIGE 200
FDADKAELIN KLLTRMQGVQ QAKESKYIML HAPAGKLEQI KALLPGAEDP 250
TVLPLSADKQ KVAVHLVSTE NLFWETMEQL KELGASSILV LPIEKMME 298
Length:298
Mass (Da):32,845
Last modified:May 23, 2003 - v1
Checksum:i1DC3A1620CA4F108
GO

Sequence cautioni

The sequence BAC59400.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000031 Genomic DNA. Translation: BAC59400.1. Different initiation.
RefSeqiNP_797516.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC59400; BAC59400; BAC59400.
GeneIDi1188642.
KEGGivpa:VP1137.
PATRICi20140484. VBIVibPar50997_1079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000031 Genomic DNA. Translation: BAC59400.1 . Different initiation.
RefSeqi NP_797516.1. NC_004603.1.

3D structure databases

ProteinModelPortali Q87QL2.
SMRi Q87QL2. Positions 5-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223926.VP1137.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC59400 ; BAC59400 ; BAC59400 .
GeneIDi 1188642.
KEGGi vpa:VP1137.
PATRICi 20140484. VBIVibPar50997_1079.

Phylogenomic databases

eggNOGi COG0040.
HOGENOMi HOG000223247.
KOi K00765.
OMAi SWRESRD.
OrthoDBi EOG66MQT3.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00006 .
BioCyci VPAR223926:GHK4-1186-MONOMER.

Family and domain databases

Gene3Di 3.30.70.120. 1 hit.
HAMAPi MF_00079. HisG_Long.
InterProi IPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view ]
PANTHERi PTHR21403. PTHR21403. 1 hit.
Pfami PF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view ]
SUPFAMi SSF54913. SSF54913. 1 hit.
TIGRFAMsi TIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEi PS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.

Entry informationi

Entry nameiHIS1_VIBPA
AccessioniPrimary (citable) accession number: Q87QL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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