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Q87QL1

- HISX_VIBPA

UniProt

Q87QL1 - HISX_VIBPA

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NADUniRule annotation
Binding sitei185 – 1851NADUniRule annotation
Binding sitei208 – 2081NADUniRule annotation
Binding sitei234 – 2341SubstrateUniRule annotation
Metal bindingi256 – 2561ZincUniRule annotation
Binding sitei256 – 2561SubstrateUniRule annotation
Metal bindingi259 – 2591ZincUniRule annotation
Binding sitei259 – 2591SubstrateUniRule annotation
Active sitei323 – 3231Proton acceptorUniRule annotation
Active sitei324 – 3241Proton acceptorUniRule annotation
Binding sitei324 – 3241SubstrateUniRule annotation
Metal bindingi357 – 3571ZincUniRule annotation
Binding sitei357 – 3571SubstrateUniRule annotation
Binding sitei411 – 4111SubstrateUniRule annotation
Metal bindingi416 – 4161ZincUniRule annotation
Binding sitei416 – 4161SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-1187-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:VP1138
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002493: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Histidinol dehydrogenasePRO_0000135876Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi223926.VP1138.

Structurei

3D structure databases

ProteinModelPortaliQ87QL1.
SMRiQ87QL1. Positions 6-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87QL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTVVWQSLS EEQQDAILER PAIAEGANIT AAVADVIAKV RTQGDAALLE
60 70 80 90 100
LTEKFDRVKP ESIRVPSKEI NAASERLSAE MKQALEQAYS NIAKFHKAQK
110 120 130 140 150
PQPIKVETQP GVMCEQVTRP IQKVGLYIPG GSAPLPSTVL MLGVPAKIAG
160 170 180 190 200
CRKVVLCSPP PIADEILYVA KLCGIDEVYN VGGGQAVAAM AYGTKSVSKV
210 220 230 240 250
DKIFGPGNAY VTEAKRQVSN DFRGAAIDMP AGPSEVLVIA DETADPDFIA
260 270 280 290 300
ADLLSQAEHG PDSQVVLVTP SPIVADQVTD AVQRQLKALS RADIAQKALA
310 320 330 340 350
SSLIIISESI TQAVSISNYY GPEHLIVQTK NPRELLPLLD NAGSIFLGDW
360 370 380 390 400
SPESAGDYAS GTNHVLPTYG YTRTYSSLGL ADFSKRMTVQ ELSAEGLQNL
410 420 430
APTVVTMAEA EGLDAHKRAV TIRVEKLTQN R
Length:431
Mass (Da):46,099
Last modified:June 6, 2003 - v1
Checksum:iD909E8885AF3DC93
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000031 Genomic DNA. Translation: BAC59401.1.
RefSeqiNP_797517.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC59401; BAC59401; BAC59401.
GeneIDi1188643.
KEGGivpa:VP1138.
PATRICi20140486. VBIVibPar50997_1080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000031 Genomic DNA. Translation: BAC59401.1 .
RefSeqi NP_797517.1. NC_004603.1.

3D structure databases

ProteinModelPortali Q87QL1.
SMRi Q87QL1. Positions 6-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223926.VP1138.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC59401 ; BAC59401 ; BAC59401 .
GeneIDi 1188643.
KEGGi vpa:VP1138.
PATRICi 20140486. VBIVibPar50997_1080.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci VPAR223926:GHK4-1187-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.

Entry informationi

Entry nameiHISX_VIBPA
AccessioniPrimary (citable) accession number: Q87QL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: June 6, 2003
Last modified: October 1, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3