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Q87Q52

- CDD_VIBPA

UniProt

Q87Q52 - CDD_VIBPA

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Protein

Cytidine deaminase

Gene
cdd, VP1298
Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.UniRule annotation

Catalytic activityi

Cytidine + H2O = uridine + NH3.UniRule annotation
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotation

Cofactori

Binds 1 zinc ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021Zinc; catalytic By similarity
Active sitei104 – 1041Proton donor By similarity
Metal bindingi129 – 1291Zinc; catalytic By similarity
Metal bindingi132 – 1321Zinc; catalytic By similarity

GO - Molecular functioni

  1. cytidine deaminase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-1347-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminase (EC:3.5.4.5)
Alternative name(s):
Cytidine aminohydrolase
Short name:
CDA
Gene namesi
Name:cdd
Ordered Locus Names:VP1298
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002493: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Cytidine deaminaseUniRule annotationPRO_0000171671Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi223926.VP1298.

Structurei

3D structure databases

ProteinModelPortaliQ87Q52.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 14283CMP/dCMP deaminase zinc-bindingAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 913Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0295.
HOGENOMiHOG000218617.
KOiK01489.
OMAiNRSHAPY.
OrthoDBiEOG6XDH25.

Family and domain databases

HAMAPiMF_01558. Cyt_deam.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR013171. Cyd/dCyd_deaminase_Zn-bd.
IPR006263. Cyt_deam_dimer.
IPR016193. Cytidine_deaminase-like.
IPR020797. Cytidine_deaminase_bacteria.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
PF08211. dCMP_cyt_deam_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAMiSSF53927. SSF53927. 2 hits.
TIGRFAMsiTIGR01355. cyt_deam_dimer. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87Q52-1 [UniParc]FASTAAdd to Basket

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MKSRIEQALA SAPEALSKQL APIVLADDFD ATLSAQQFEQ LLSATSLSDK    50
ELRVALLPFA AAYSYAPISE FYVGAIVRGL SGRLYFGANM EFFGVQLGQT 100
VHAEQSAISH AWMKGEHGVK DITINFSPCG HCRQFMNELS TAKELKVQLP 150
ERDEKSLHEY LPEAFGPADL GIESGLMAEV KHQFVCDDKD ALIQQAVEAM 200
NMSHAPYTNN LSGLALELAN GRVFKGAYAE NAAFNPSLPP LQVALIQVLL 250
AGETFDSIKA AALVENSEGK ISHLADTQST LEALNPDIPV SFVNV 295
Length:295
Mass (Da):31,912
Last modified:June 1, 2003 - v1
Checksum:i215BA72CE1F958BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000031 Genomic DNA. Translation: BAC59561.1.
RefSeqiNP_797677.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC59561; BAC59561; BAC59561.
GeneIDi1188803.
KEGGivpa:VP1298.
PATRICi20140802. VBIVibPar50997_1238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000031 Genomic DNA. Translation: BAC59561.1 .
RefSeqi NP_797677.1. NC_004603.1.

3D structure databases

ProteinModelPortali Q87Q52.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223926.VP1298.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC59561 ; BAC59561 ; BAC59561 .
GeneIDi 1188803.
KEGGi vpa:VP1298.
PATRICi 20140802. VBIVibPar50997_1238.

Phylogenomic databases

eggNOGi COG0295.
HOGENOMi HOG000218617.
KOi K01489.
OMAi NRSHAPY.
OrthoDBi EOG6XDH25.

Enzyme and pathway databases

BioCyci VPAR223926:GHK4-1347-MONOMER.

Family and domain databases

HAMAPi MF_01558. Cyt_deam.
InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR013171. Cyd/dCyd_deaminase_Zn-bd.
IPR006263. Cyt_deam_dimer.
IPR016193. Cytidine_deaminase-like.
IPR020797. Cytidine_deaminase_bacteria.
[Graphical view ]
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
PF08211. dCMP_cyt_deam_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAMi SSF53927. SSF53927. 2 hits.
TIGRFAMsi TIGR01355. cyt_deam_dimer. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.

Entry informationi

Entry nameiCDD_VIBPA
AccessioniPrimary (citable) accession number: Q87Q52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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