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Q87Q30 (ISPD2_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2

EC=2.7.7.60
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase 2
MEP cytidylyltransferase 2
Short name=MCT 2
Gene names
Name:ispD2
Ordered Locus Names:VP1320
OrganismVibrio parahaemolyticus [Complete proteome] [HAMAP]
Taxonomic identifier670 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108

Sequence similarities

Belongs to the IspD family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 238238Putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2 HAMAP MF_00108
PRO_0000075645

Sites

Site141Transition state stabilizer By similarity
Site221Transition state stabilizer By similarity
Site1571Positions MEP for the nucleophilic attack By similarity
Site2141Positions MEP for the nucleophilic attack By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87Q30 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 3BEEB98734370510

FASTA23827,076
        10         20         30         40         50         60 
MNVALIFAGG VGTRMQNSTK PKQFLELYNK PVIIYTLEKF EENKNIDAIV VVCVEPWIDY 

        70         80         90        100        110        120 
LRKLLFKFDI QKVKFVIPGG ETGQESIFNG LCKIEEEFDH NSVVLIHDGV RPLINDEIIN 

       130        140        150        160        170        180 
RNIEAVKSHG SAITTCPPVE TFVLVDNEDV VKDVHDRSLS RLAKAPQSFY LRDILKVHRQ 

       190        200        210        220        230 
AREDCYTEAI DSCSLMTKYG YDVRLVSGIS ENIKITSPID FFIFKAIIDT QENLQVFG 

« Hide

References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633 / Serotype O3:K6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000031 Genomic DNA. Translation: BAC59583.1.
RefSeqNP_797699.1. NC_004603.1.

3D structure databases

ProteinModelPortalQ87Q30.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1188825.
GenomeReviewsGene locus VP1320 in contig BA000031_GR.
KEGGvpa:VP1320.
NMPDRfig|223926.1.peg.1320.
PATRIC20140850. VBIVibPar50997_1262.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG672839.
OMAVDETITR.
ProtClustDBCLSK904510.

Enzyme and pathway databases

BioCycVPAR223926:VP1320-MONOMER.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPD2_VIBPA
AccessionPrimary (citable) accession number: Q87Q30
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families