Reviewed,
UniProtKB/Swiss-Prot Q87Q30 (ISPD2_VIBPA)
Last modified
January 19, 2010.
Version 37.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2 EC=2.7.7.60 Alternative name(s): 4-diphosphocytidyl-2C-methyl-D-erythritol synthase 2 MEP cytidylyltransferase 2 Short name=MCT 2 | ||||
| Gene names |
| ||||
| Organism | Vibrio parahaemolyticus [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 670 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio |
Protein attributes
| Sequence length | 238 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108 |
| Catalytic activity | CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108 |
| Pathway | Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108 |
| Sequence similarities | Belongs to the ispD family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Isoprene biosynthesis |
| Molecular function | Nucleotidyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Molecular function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 238 | 238 | Putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2 HAMAP MF_00108 | PRO_0000075645 | |||||
Sites | |||||||||
| Site | 14 | 1 | Transition state stabilizer By similarity | ||||||
| Site | 22 | 1 | Transition state stabilizer By similarity | ||||||
| Site | 157 | 1 | Positions MEP for the nucleophilic attack By similarity | ||||||
| Site | 214 | 1 | Positions MEP for the nucleophilic attack By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae." Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T. Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RIMD 2210633 / Serotype O3:K6. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000031 Genomic DNA. Translation: BAC59583.1. |
| RefSeq | NP_797699.1. |
3D structure databases | |
| SMR | Q87Q30. Positions 3-228. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1188825. |
| GenomeReviews | Gene locus VP1320 in contig BA000031_GR. |
| KEGG | vpa:VP1320. |
| NMPDR | fig|223926.1.peg.1320. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG672839. |
| OMA | KWSSASA. |
Enzyme and pathway databases | |
| BioCyc | VPAR223926:VP1320-MONOMER. |
| BRENDA | 2.7.7.60. 3063. |
Family and domain databases | |
| HAMAP | MF_00108. IspD. [Tree] |
| InterPro | IPR001228. ISPD_synthase. IPR018294. ISPD_synthase_CS. [Graphical view] |
| Pfam | PF01128. IspD. 1 hit. [Graphical view] |
| PROSITE | PS01295. ISPD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ISPD2_VIBPA | ||||||||
| Accession | Primary (citable) accession number: Q87Q30 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


