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Q87PK8 (NAGK_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetyl-D-glucosamine kinase

EC=2.7.1.59
Alternative name(s):
GlcNAc kinase
Gene names
Name:nagK
Ordered Locus Names:VP1494
OrganismVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) [Complete proteome] [HAMAP]
Taxonomic identifier223926 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P By similarity. HAMAP-Rule MF_01271

Catalytic activity

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate. HAMAP-Rule MF_01271

Pathway

Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_01271

Sequence similarities

Belongs to the ROK (NagC/XylR) family. NagK subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302N-acetyl-D-glucosamine kinase HAMAP-Rule MF_01271
PRO_0000270121

Regions

Nucleotide binding4 – 118ATP Potential
Nucleotide binding133 – 1408ATP Potential

Sites

Metal binding1571Zinc By similarity
Metal binding1771Zinc By similarity
Metal binding1791Zinc By similarity
Metal binding1841Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87PK8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 1B91F61FB9216FB4

FASTA30232,775
        10         20         30         40         50         60 
MYYGFDVGGT KIEFGAFNEK LERVATERVP TPTDNYELLV DTIAELVNKY DAEFGCEGTI 

        70         80         90        100        110        120 
GLGLPGMEDA DDATVLTVNV PAAKGKPLRA DLEAKIGRSV KIENDANCFA LSEAWDEELQ 

       130        140        150        160        170        180 
DEPSVLGLIL GTGFGGGFIY DGKVFSGRNH VAGEVGHTRL PIDAWFHLGE NAPLLGCGCD 

       190        200        210        220        230        240 
KKGCLDSYLS GRGFELLYAH YYGEEKKAID IIKAHAEGEA KAVEHVERFM ELLAICFANI 

       250        260        270        280        290        300 
FTATDPHVVV LGGGLSNFEL IYEEMPKRIP KYLLSVAKCP KIIKAKHGDS GGVRGAAFLH 


IK 

« Hide

References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000031 Genomic DNA. Translation: BAC59757.1.
RefSeqNP_797873.1. NC_004603.1.

3D structure databases

ProteinModelPortalQ87PK8.
SMRQ87PK8. Positions 1-301.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING223926.VP1494.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC59757; BAC59757; BAC59757.
GeneID1189001.
KEGGvpa:VP1494.
PATRIC20141184. VBIVibPar50997_1427.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1940.
HOGENOMHOG000150087.
KOK00884.
OMACHEERMS.
OrthoDBEOG61P6P0.
ProtClustDBPRK13310.

Enzyme and pathway databases

BioCycVPAR223926:GHK4-1545-MONOMER.
UniPathwayUPA00544.

Family and domain databases

HAMAPMF_01271. GlcNAc_kinase.
InterProIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamPF00480. ROK. 1 hit.
[Graphical view]
PROSITEPS01125. ROK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAGK_VIBPA
AccessionPrimary (citable) accession number: Q87PK8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways