Cytochrome c-552 precursor - Vibrio parahaemolyticus

Contribute

Send feedback

Reviewed, UniProtKB/Swiss-Prot Q87ND9 (NRFA_VIBPA)

Last modified November 4, 2008. Version 41. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
    Cytochrome c-552
    EC=1.7.2.2
Alternative name(s):
    Ammonia-forming cytochrome c nitrite reductase
      Short name=Cytochrome c nitrite reductase

Gene names

Name:	nrfA
Ordered Locus Names:	VP1929

Organism

Vibrio parahaemolyticus [Complete proteome] [HAMAP]

Taxonomic identifier

670 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Hide | Top

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

Hide | Top

General annotation (Comments)

Function	Plays a role in nitrite reduction By similarity.
Catalytic activity	NH(3) + 2 H(2)O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H(+).
Cofactor	Binds 1 calcium ion per monomer By similarity. Binds 5 heme groups covalently per monomer By similarity.
Pathway	Nitrogen metabolism; nitrate reduction (assimilation).
Subcellular location	PeriplasmBy similarity.
Sequence similarities	Belongs to the cytochrome c-552 family.

Hide | Top

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Periplasm
Domain	Signal
Ligand	Calcium Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW nitrogen compound metabolic process Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	periplasmic space Inferred from electronic annotation. Source: HAMAP
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW nitrite reductase (cytochrome, ammonia-forming) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

Potential

Chain

30 – 475

446

Cytochrome c-552

PRO_0000268982

Sites

Metal binding

Iron (heme 3 axial ligand) By similarity

Metal binding

124

Iron (heme 1 axial ligand) By similarity

Metal binding

162

Iron (heme 2 axial ligand) By similarity

Metal binding

211

Iron (heme 3 axial ligand) By similarity

Metal binding

213

Calcium By similarity

Metal binding

214

Calcium; via carbonyl oxygen By similarity

Metal binding

259

Calcium; via carbonyl oxygen By similarity

Metal binding

261

Calcium By similarity

Metal binding

273

Iron (heme 5 axial ligand) By similarity

Metal binding

284

Iron (heme 4 axial ligand) By similarity

Metal binding

299

Iron (heme 2 axial ligand) By similarity

Metal binding

316

Iron (heme 5 axial ligand) By similarity

Metal binding

391

Iron (heme 4 axial ligand) By similarity

Binding site

120

Heme 1 (covalent) By similarity

Binding site

123

Heme 1 (covalent) By similarity

Binding site

158

Heme 2 (covalent) By similarity

Binding site

161

Heme 2 (covalent) By similarity

Binding site

207

Heme 3 (covalent) By similarity

Binding site

210

Heme 3 (covalent) By similarity

Binding site

214

Substrate By similarity

Binding site

262

Substrate By similarity

Binding site

280

Heme 4 (covalent) By similarity

Binding site

283

Heme 4 (covalent) By similarity

Binding site

312

Heme 5 (covalent) By similarity

Binding site

315

Heme 5 (covalent) By similarity

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

Q87ND9-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 1BB4C5D421A0E797
Show »

FASTA

475

53,262

        10         20         30         40         50         60 
MSIKHWMSAP IAVATLFASQ LLLAGSVLAA ENNDRLDPRN DAFEQKHPDQ YHSWKATSES 

        70         80         90        100        110        120 
KHIEDALSED PNMVILWAGY GFAKDYNKAR GHFYALDDVR QTLRTGAPAD ENSGPMPMAC 

       130        140        150        160        170        180 
WSCKSPDVAR VIEERGEDGY FSGKWARLGS EIVNPIGCSD CHDTRSEKFN QGEPELALTR 

       190        200        210        220        230        240 
PYVERAFDVI GKNFDDQSRL DKQASVCAQC HVEYYFTGPT KAVKFPWDMG TTVGDMEKYY 

       250        260        270        280        290        300 
DALDFKDWTH AVSKAPMLKA QHPGFETWRE GIHGKNKVVC VDCHMPKVTK ADGTVYTDHK 

       310        320        330        340        350        360 
VGNPFDRFED TCAQCHTQTK EQLRNIVSSR KALVLNMKLT AEKQIVAAHF EAGEAWKAGA 

       370        380        390        400        410        420 
TEEEMKPILQ DIRHAQWRWD YAIASHGVHM HAPEVALEVL GTAVDRAADA RTKLVRLLAT 

       430        440        450        460        470 
KGITEPVQIP DISTKAKAQE ALGMDMEKMN ADKKHFLDTV VPDWDKAAAE REATY

« Hide

Hide | Top

References

[1]

"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633 / Serotype O3:K6.

Hide | Top

Cross-references

Sequence databases
	BA000031 Genomic DNA. Translation: BAC60192.1.
RefSeq	NP_798308.1.
3D structure databases
HSSP	HSSP built from PDB template 1GU6 based on UniProtKB P32050.
ModBase	Search...
Genome annotation databases
GeneID	1189436.
GenomeReviews	Gene locus VP1929 in contig BA000031_GR.
KEGG	vpa:VP1929.
NMPDR	fig\|223926.1.peg.1929.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q87ND9.
Enzyme and pathway databases
BioCyc	VPAR223926:VP1929-MON.
Family and domain databases
HAMAP	MF_01182. [Tree]
InterPro	IPR003321. Cyt_c552. IPR017570. Cytc_552_NO2Rdtase_formate-dep. IPR011031. Multihaem_cyt. [Graphical view]
Pfam	PF02335. Cytochrom_C552. 1 hit. [Graphical view]
PIRSF	PIRSF000243. Cyt_c552. 1 hit.
PROSITE	PS51008. MULTIHEME_CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

Hide | Top

Entry information

Entry name

NRFA_VIBPA

Accession

Primary (citable) accession number: Q87ND9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	June 1, 2003
Last modified:	November 4, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents