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Q87NB7 (RLUB_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosomal large subunit pseudouridine synthase B

EC=5.4.99.22
Alternative name(s):
23S rRNA pseudouridine(2605) synthase
rRNA pseudouridylate synthase B
rRNA-uridine isomerase B
Gene names
Name:rluB
Ordered Locus Names:VP1951
OrganismVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) [Complete proteome] [HAMAP]
Taxonomic identifier223926 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA By similarity.

Catalytic activity

23S rRNA uridine(2605) = 23S rRNA pseudouridine(2605).

Sequence similarities

Belongs to the pseudouridine synthase RsuA family.

Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
   Biological processrRNA processing
   LigandRNA-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpseudouridine synthesis

Inferred from electronic annotation. Source: InterPro

rRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

pseudouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Ribosomal large subunit pseudouridine synthase B
PRO_0000099993

Regions

Domain3 – 7472S4 RNA-binding

Sites

Active site1091Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87NB7 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 6440A74C58CC2893

FASTA31235,996
        10         20         30         40         50         60 
MSEKLQKVLA RAGHGSRREI ESLIKSGRVS VNGVVAKLGE RLEDESSVVR IDGHIVSAKV 

        70         80         90        100        110        120 
QEEVICRVLA YYKPEGELCT RHDPEGRRTV FDRLPKIRGS RWISVGRLDA NTSGLLLFTT 

       130        140        150        160        170        180 
DGELANRLMH PSRQVEREYL VRVFGEVTEQ KVRNLVKGVE LEDGLARFED VVYAGGEGMN 

       190        200        210        220        230        240 
HTFYVVINEG RNREVRRLWE SQECTVSRLK RVRYGDIFLD KKLPRGGWME LDLKEVNYLR 

       250        260        270        280        290        300 
ELVELRPEKE TMLDLSKDNT SRKRERARSQ KIRRAVKRHE ERVSTSKGRS NNPARRKPKK 

       310 
NAGEQGARNK HR 

« Hide

References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000031 Genomic DNA. Translation: BAC60214.1.
RefSeqNP_798330.1. NC_004603.1.

3D structure databases

ProteinModelPortalQ87NB7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING223926.VP1951.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC60214; BAC60214; BAC60214.
GeneID1189462.
KEGGvpa:VP1951.
PATRIC20142070. VBIVibPar50997_1866.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1187.
HOGENOMHOG000044954.
KOK06178.
OMAPRGGWIE.
OrthoDBEOG6130DV.
ProtClustDBCLSK874246.

Enzyme and pathway databases

BioCycVPAR223926:GHK4-2006-MONOMER.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTSM00363. S4. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
TIGRFAMsTIGR00093. TIGR00093. 1 hit.
PROSITEPS01149. PSI_RSU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRLUB_VIBPA
AccessionPrimary (citable) accession number: Q87NB7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: November 13, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families