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Q87NB7

- RLUB_VIBPA

UniProt

Q87NB7 - RLUB_VIBPA

Protein

Ribosomal large subunit pseudouridine synthase B

Gene

rluB

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA.By similarity

    Catalytic activityi

    23S rRNA uridine(2605) = 23S rRNA pseudouridine(2605).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei109 – 1091NucleophileBy similarity

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. pseudouridine synthesis Source: InterPro
    2. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciVPAR223926:GHK4-2006-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal large subunit pseudouridine synthase B (EC:5.4.99.22)
    Alternative name(s):
    23S rRNA pseudouridine(2605) synthase
    rRNA pseudouridylate synthase B
    rRNA-uridine isomerase B
    Gene namesi
    Name:rluB
    Ordered Locus Names:VP1951
    OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
    Taxonomic identifieri223926 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002493: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Ribosomal large subunit pseudouridine synthase BPRO_0000099993Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi223926.VP1951.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87NB7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 7472S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pseudouridine synthase RsuA family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1187.
    HOGENOMiHOG000044954.
    KOiK06178.
    OMAiARSQKIR.
    OrthoDBiEOG6130DV.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
    IPR018496. PsdUridine_synth_RsuA/RluB_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PfamiPF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 1 hit.
    TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
    PROSITEiPS01149. PSI_RSU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q87NB7-1 [UniParc]FASTAAdd to Basket

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    MSEKLQKVLA RAGHGSRREI ESLIKSGRVS VNGVVAKLGE RLEDESSVVR    50
    IDGHIVSAKV QEEVICRVLA YYKPEGELCT RHDPEGRRTV FDRLPKIRGS 100
    RWISVGRLDA NTSGLLLFTT DGELANRLMH PSRQVEREYL VRVFGEVTEQ 150
    KVRNLVKGVE LEDGLARFED VVYAGGEGMN HTFYVVINEG RNREVRRLWE 200
    SQECTVSRLK RVRYGDIFLD KKLPRGGWME LDLKEVNYLR ELVELRPEKE 250
    TMLDLSKDNT SRKRERARSQ KIRRAVKRHE ERVSTSKGRS NNPARRKPKK 300
    NAGEQGARNK HR 312
    Length:312
    Mass (Da):35,996
    Last modified:June 1, 2003 - v1
    Checksum:i6440A74C58CC2893
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000031 Genomic DNA. Translation: BAC60214.1.
    RefSeqiNP_798330.1. NC_004603.1.

    Genome annotation databases

    EnsemblBacteriaiBAC60214; BAC60214; BAC60214.
    GeneIDi1189462.
    KEGGivpa:VP1951.
    PATRICi20142070. VBIVibPar50997_1866.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000031 Genomic DNA. Translation: BAC60214.1 .
    RefSeqi NP_798330.1. NC_004603.1.

    3D structure databases

    ProteinModelPortali Q87NB7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 223926.VP1951.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC60214 ; BAC60214 ; BAC60214 .
    GeneIDi 1189462.
    KEGGi vpa:VP1951.
    PATRICi 20142070. VBIVibPar50997_1866.

    Phylogenomic databases

    eggNOGi COG1187.
    HOGENOMi HOG000044954.
    KOi K06178.
    OMAi ARSQKIR.
    OrthoDBi EOG6130DV.

    Enzyme and pathway databases

    BioCyci VPAR223926:GHK4-2006-MONOMER.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
    IPR018496. PsdUridine_synth_RsuA/RluB_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    Pfami PF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 1 hit.
    TIGRFAMsi TIGR00093. TIGR00093. 1 hit.
    PROSITEi PS01149. PSI_RSU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
      Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
      Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RIMD 2210633.

    Entry informationi

    Entry nameiRLUB_VIBPA
    AccessioniPrimary (citable) accession number: Q87NB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3