Q87MD6 (GLND_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
[Protein-PII] uridylyltransferase
Short name=PII uridylyl-transferase
EC=2.7.7.59

Alternative name(s):
UTase
Uridylyl-removing enzyme

Gene names

Name:	glnD
Ordered Locus Names:	VP2320

Organism

Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) [Complete proteome] [HAMAP]

Taxonomic identifier

223926 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio harveyi group › Vibrio parahaemolyticus

Protein attributes

Sequence length	874 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein By similarity. HAMAP-Rule MF_00277
Catalytic activity	UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII]. HAMAP-Rule MF_00277
Sequence similarities	Belongs to the GlnD family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	[protein-PII] uridylyltransferase activity Inferred from electronic annotation. Source: EC amino acid binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: InterPro phosphoric diester hydrolase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 874	874	[Protein-PII] uridylyltransferase HAMAP-Rule MF_00277		PRO_0000192773

Sequences

	Sequence		Length	Mass (Da)
	Q87MD6 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 1B849BC63393E97E	FASTA	874	100,247
	10 20 30 40 50 60 MPLQSPLTFS DEQINIGELK QELEKFSSTQ KQEFLNHHPV TSLVLARAEY MDLLLTRLWQ 70 80 90 100 110 120 YFGFNDIYNI SLVAVGGYGR GELHPLSDID ILVLSNNKLP TALEAKISEF ITLLWDLKLE 130 140 150 160 170 180 VGHAVRTVNE CAQIGRDDLT VATNLQEARL LCGSEDTFQA LKKVVLSDSF WPSETFYRAK 190 200 210 220 230 240 IQEQRERHAR YHDTTYNLEP DIKSTPGGLR DIHTLSWVAR RHFGATSLLE MSRYGFLTDA 250 260 270 280 290 300 EYRELVECQD FLWRVRFALH IELRRYDNRL TFAHQAQVAE NLGYVGEGNR GVEMMMKEFY 310 320 330 340 350 360 RTLRRVAELN KMLLKLFDQA IINGGATENA EILDADFQRR GSLIEARKPA LFQARPETIL 370 380 390 400 410 420 DMFLHIANDS TIEGVSPPTL RQLRTARRRL NKFLHTIPAA REKFLALCRH PNALHKAFSL 430 440 450 460 470 480 MHRLGVMAAY LPQWSQIVGQ MQFDLFHAYT VDEHSIRLLK HINTFNNPDN HAKHPICCDI 490 500 510 520 530 540 YPRMQKKELL IIAAIFHDIG KGRGGDHSVI GEGEAYDFCI EHGLSKPEAK LVGWLVRHHL 550 560 570 580 590 600 LMSVTAQRRD IYDPDVITEF AKQVRDEESL EYLVCLTVAD ICATNPELWN AWKRTLLAEL 610 620 630 640 650 660 FYSTQRALRR GLENPVDVRE RIRHNQQMAS ALLRKEGFSA RQIEVLWQRF KADYFLRHTH 670 680 690 700 710 720 TQIAWHCAHL LRMDDPNKPL VLISKKATRG GTEVFVYTKD QPALFATVVA ELDRRNFNVH 730 740 750 760 770 780 DAQIMTSKDG HVIDTFMVLD QHGEAIDESR HAAVIKHLTH VLEAGRPTKI KTRRTPNKLQ 790 800 810 820 830 840 HFNVKTKVDF LPTKGKKHTL MEFVALDTPG LLAKVGRTFA DLNINLHGAK ITTIGERAED 850 860 870 LFILTSEAGG RLSEEQQNEL RDKLIEKLSD AVTA

References

[1]

"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae." Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T. Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RIMD 2210633.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000031 Genomic DNA. Translation: BAC60583.1.
RefSeq	NP_798699.1. NC_004603.1.
3D structure databases
ProteinModelPortal	Q87MD6.
ModBase	Search...
Protein-protein interaction databases
STRING	223926.VP2320.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC60583; BAC60583; BAC60583.
GeneID	1189833.
KEGG	vpa:VP2320.
PATRIC	20142786. VBIVibPar50997_2222.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2844.
HOGENOM	HOG000261778.
KO	K00990.
OMA	SPKVWNA.
ProtClustDB	PRK05007.
Enzyme and pathway databases
BioCyc	VPAR223926:GHK4-2377-MONOMER.
Family and domain databases
Gene3D	1.10.3210.10. 1 hit.
HAMAP	MF_00277. PII_uridylyl-transf.
InterPro	IPR002912. ACT_dom. IPR010043. GlnD_Uridyltrans. IPR003607. HD/PDEase_dom. IPR006674. HD_domain. IPR002934. Nucleotidyltransferase. IPR013546. PII_UdlTrfase/GS_AdlTrfase. [Graphical view]
PANTHER	PTHR13734:SF1. PTHR13734:SF1. 1 hit.
Pfam	PF01842. ACT. 2 hits. PF08335. GlnD_UR_UTase. 1 hit. PF01966. HD. 1 hit. PF01909. NTP_transf_2. 1 hit. [Graphical view]
PIRSF	PIRSF006288. PII_uridyltransf. 1 hit.
SMART	SM00471. HDc. 1 hit. [Graphical view]
TIGRFAMs	TIGR01693. UTase_glnD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLND_VIBPA

Accession

Primary (citable) accession number: Q87MD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2003
Last sequence update:	June 1, 2003
Last modified:	May 29, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program