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Protein

Na(+)-translocating NADH-quinone reductase subunit B

Gene

nqrB

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.UniRule annotation

Catalytic activityi

NADH + ubiquinone + n Na+(In) = NAD+ + ubiquinol + n Na+(Out).UniRule annotation

Cofactori

FMNUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Flavoprotein, FMN, NAD, Sodium, Ubiquinone

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-2407-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)-translocating NADH-quinone reductase subunit BUniRule annotation (EC:1.6.5.8UniRule annotation)
Short name:
Na(+)-NQR subunit BUniRule annotation
Short name:
Na(+)-translocating NQR subunit BUniRule annotation
Alternative name(s):
NQR complex subunit BUniRule annotation
NQR-1 subunit BUniRule annotation
Gene namesi
Name:nqrBUniRule annotation
Ordered Locus Names:VP2350
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4018HelicalUniRule annotationAdd
BLAST
Transmembranei56 – 7621HelicalUniRule annotationAdd
BLAST
Transmembranei129 – 14921HelicalUniRule annotationAdd
BLAST
Transmembranei164 – 18421HelicalUniRule annotationAdd
BLAST
Transmembranei268 – 28821HelicalUniRule annotationAdd
BLAST
Transmembranei297 – 31721HelicalUniRule annotationAdd
BLAST
Transmembranei325 – 34521HelicalUniRule annotationAdd
BLAST
Transmembranei358 – 37821HelicalUniRule annotationAdd
BLAST
Transmembranei381 – 40121HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Na(+)-translocating NADH-quinone reductase subunit BPRO_0000074446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361FMN phosphoryl threonineUniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.UniRule annotation

Protein-protein interaction databases

STRINGi223926.VP2350.

Family & Domainsi

Sequence similaritiesi

Belongs to the NqrB/RnfD family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108J5C. Bacteria.
COG1805. LUCA.
HOGENOMiHOG000273666.
KOiK00347.
OMAiTVFYTPG.
OrthoDBiEOG65BDMX.

Family and domain databases

HAMAPiMF_00426. NqrB.
InterProiIPR004338. NADH_Q_Rdtase_NQR2_RnfD.
IPR010966. NqrB.
[Graphical view]
PANTHERiPTHR30578:SF1. PTHR30578:SF1. 1 hit.
PfamiPF03116. NQR2_RnfD_RnfE. 1 hit.
[Graphical view]
PIRSFiPIRSF016055. NADH-UbQ_OxRdtase_B_su. 1 hit.
TIGRFAMsiTIGR01937. nqrB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q87MA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKKFLEDI EHHFEPGGKH EKWFALYEAV ATVFYTPGLV TKKSSHVRDS
60 70 80 90 100
VDLKRIMIMV WFAVFPAMFW GMYNAGGQAI AALNHMYAGD QLATVIAGNW
110 120 130 140 150
HYWLTEMLGG SISADAGVGS KMLLGATYFL PIYATVFLVG GFWEVLFCMV
160 170 180 190 200
RKHEVNEGFF VTSILFALIV PPTLPLWQAA LGITFGVVVA KEIFGGTGRN
210 220 230 240 250
FLNPALAGRA FLFFAYPAQI SGDVVWTAAD GFSGATALSQ WAHGGSGALI
260 270 280 290 300
NNITGAPITW MDAFIGNIPG SIGEVSTLAL MIGAAMIVYM RIASWRIIAG
310 320 330 340 350
VMIGMIAVST LFNVVGSDTN PMFNMPWHWH LVLGGFAFGM FFMATDPVSA
360 370 380 390 400
SFTNKGKWWY GILIGAMCVM IRVVNPAYPE GMMLAILFAN LFAPLFDHVV
410
IEKNIKRRLA RYGK
Length:414
Mass (Da):45,335
Last modified:June 1, 2003 - v1
Checksum:iC8FBA926FFCBC933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC60613.1.
RefSeqiNP_798729.1. NC_004603.1.
WP_005456580.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC60613; BAC60613; BAC60613.
GeneIDi1189863.
KEGGivpa:VP2350.
PATRICi20142848. VBIVibPar50997_2253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC60613.1.
RefSeqiNP_798729.1. NC_004603.1.
WP_005456580.1. NC_004603.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi223926.VP2350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC60613; BAC60613; BAC60613.
GeneIDi1189863.
KEGGivpa:VP2350.
PATRICi20142848. VBIVibPar50997_2253.

Phylogenomic databases

eggNOGiENOG4108J5C. Bacteria.
COG1805. LUCA.
HOGENOMiHOG000273666.
KOiK00347.
OMAiTVFYTPG.
OrthoDBiEOG65BDMX.

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-2407-MONOMER.

Family and domain databases

HAMAPiMF_00426. NqrB.
InterProiIPR004338. NADH_Q_Rdtase_NQR2_RnfD.
IPR010966. NqrB.
[Graphical view]
PANTHERiPTHR30578:SF1. PTHR30578:SF1. 1 hit.
PfamiPF03116. NQR2_RnfD_RnfE. 1 hit.
[Graphical view]
PIRSFiPIRSF016055. NADH-UbQ_OxRdtase_B_su. 1 hit.
TIGRFAMsiTIGR01937. nqrB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.

Entry informationi

Entry nameiNQRB_VIBPA
AccessioniPrimary (citable) accession number: Q87MA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: November 11, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.