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Protein

Amino-acid acetyltransferase

Gene

argA

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Amino-acid acetyltransferase (argA)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-2428-MONOMER.
UniPathwayiUPA00068; UER00106.

Names & Taxonomyi

Protein namesi
Recommended name:
Amino-acid acetyltransferaseUniRule annotation (EC:2.3.1.1UniRule annotation)
Alternative name(s):
N-acetylglutamate synthaseUniRule annotation
Short name:
AGSUniRule annotation
Short name:
NAGSUniRule annotation
Gene namesi
Name:argAUniRule annotation
Ordered Locus Names:VP2371
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Amino-acid acetyltransferasePRO_0000186809Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi223926.VP2371.

Structurei

Secondary structure

1
445
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi299 – 3035Combined sources
Helixi306 – 3083Combined sources
Helixi309 – 32113Combined sources
Helixi330 – 3367Combined sources
Helixi337 – 3393Combined sources
Beta strandi340 – 3456Combined sources
Beta strandi348 – 35811Combined sources
Turni359 – 3624Combined sources
Beta strandi363 – 3719Combined sources
Helixi373 – 3753Combined sources
Beta strandi377 – 3793Combined sources
Helixi380 – 39314Combined sources
Turni394 – 3963Combined sources
Beta strandi399 – 4013Combined sources
Helixi408 – 4136Combined sources
Helixi421 – 4233Combined sources
Helixi426 – 4283Combined sources
Helixi429 – 4324Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E0KX-ray2.52A298-445[»]
ProteinModelPortaliQ87M87.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ87M87.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini299 – 438140N-acetyltransferaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the acetyltransferase family. ArgA subfamily.UniRule annotation
Contains 1 N-acetyltransferase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QZM. Bacteria.
COG0548. LUCA.
COG1246. LUCA.
HOGENOMiHOG000262225.
KOiK14682.
OMAiKQALYNY.
OrthoDBiEOG6T1WVF.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
3.40.630.30. 1 hit.
HAMAPiMF_01105. N_acetyl_glu_synth.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR000182. GNAT_dom.
IPR010167. NH2A_AcTrfase_ArgA.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF00583. Acetyltransf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000423. ArgA. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87M87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRSTALVK GFRQSTPYVN AHRGKTMVIM LGGEAVAHNN FGNIINDIAL
60 70 80 90 100
MHSLGIKVVV VYGARPQINQ LLEKQDLTTP YHKNIRITDE AALSVVMQAA
110 120 130 140 150
GQLQLAITAR LSMSLNNTPM AGTQLNVVSG NFVIAQPLGV DDGVDYCHSG
160 170 180 190 200
RIRRIDTDAI NRTLDQGSIV LLGPIASSVT GECFNLLSEE VATQLAIKLG
210 220 230 240 250
ADKLIGFCSE QGVIDDNGNA VAELLPIEAE HVIKTLSENH ASDSDYNTGT
260 270 280 290 300
LRFLKGSIAA CRAGVPRSHL ISYKVDGALI QELFSFDGIG TQVVMASAEQ
310 320 330 340 350
VRQAGIDDIG GILELIHPLE EQGILVRRSR EQLEQEIGKF TIIEKDGLII
360 370 380 390 400
GCAALYPYSE ERKAEMACVA IHPDYRDGNR GLLLLNYMKH RSKSENINQI
410 420 430 440
FVLTTHSLHW FREQGFYEVG VDYLPGAKQG LYNFQRKSKI LALDL
Length:445
Mass (Da):48,753
Last modified:June 1, 2003 - v1
Checksum:iB924E581D8DFF19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC60634.1.
RefSeqiNP_798750.1. NC_004603.1.
WP_005482311.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC60634; BAC60634; BAC60634.
GeneIDi1189884.
KEGGivpa:VP2371.
PATRICi20142892. VBIVibPar50997_2275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC60634.1.
RefSeqiNP_798750.1. NC_004603.1.
WP_005482311.1. NC_004603.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E0KX-ray2.52A298-445[»]
ProteinModelPortaliQ87M87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi223926.VP2371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC60634; BAC60634; BAC60634.
GeneIDi1189884.
KEGGivpa:VP2371.
PATRICi20142892. VBIVibPar50997_2275.

Phylogenomic databases

eggNOGiENOG4107QZM. Bacteria.
COG0548. LUCA.
COG1246. LUCA.
HOGENOMiHOG000262225.
KOiK14682.
OMAiKQALYNY.
OrthoDBiEOG6T1WVF.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00106.
BioCyciVPAR223926:GHK4-2428-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ87M87.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
3.40.630.30. 1 hit.
HAMAPiMF_01105. N_acetyl_glu_synth.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR000182. GNAT_dom.
IPR010167. NH2A_AcTrfase_ArgA.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF00583. Acetyltransf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000423. ArgA. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.

Entry informationi

Entry nameiARGA_VIBPA
AccessioniPrimary (citable) accession number: Q87M87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.